Long noncoding RNAs: A novel insight in the leukemogenesis and drug resistance in acute myeloid leukemia

2021 ◽  
Author(s):  
Anuradha Kirtonia ◽  
Milad Ashrafizadeh ◽  
Ali Zarrabi ◽  
Kiavash Hushmandi ◽  
Amirhossein Zabolian ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Noncoding Rnas ◽  
Long Noncoding Rnas ◽  
Acute Myeloid

scholarly journals LncRNA ZEB2-AS1 regulates the drug resistance of acute myeloid leukemia via the miR-142-3p/INPP4B axis

RSC Advances ◽  
2019 ◽  
Vol 9 (67) ◽  
pp. 39495-39504 ◽  
Author(s):  
Kai Wang ◽  
Jing Dai ◽  
Tao Liu ◽  
Qiong Wang ◽  
Yingxu Pang
Keyword(s):  
Drug Resistance ◽  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Noncoding Rnas ◽  
Long Noncoding Rnas ◽  
Multiple Cancers ◽  
Acute Myeloid

Dysregulation of long noncoding RNAs (lncRNAs) has been reported to participate in the process of chemoresistance in multiple cancers, including acute myeloid leukemia (AML).

scholarly journals Role of microRNAs, circRNAs and long noncoding RNAs in acute myeloid leukemia

2019 ◽  
Vol 12 (1) ◽  
Author(s):  
Yan Liu ◽  
Zhiheng Cheng ◽  
Yifan Pang ◽  
Longzhen Cui ◽  
Tingting Qian ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Noncoding Rnas ◽  
Long Noncoding Rnas ◽  
Acute Myeloid

Diverse functions of long noncoding RNAs in acute myeloid leukemia

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Srishti Mishra ◽  
Jun Liu ◽  
Li Chai ◽  
Daniel G. Tenen
Keyword(s):  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Noncoding Rnas ◽  
Long Noncoding Rnas ◽  
Acute Myeloid

Long noncoding RNAs have pivotal roles in chemoresistance of acute myeloid leukemia

2021 ◽  
Author(s):  
Mehrdad Izadirad ◽  
Leila Jafari ◽  
Alva Rani James ◽  
Juan Pablo Unfried ◽  
Zhuo-Xun Wu ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Noncoding Rnas ◽  
Long Noncoding Rnas ◽  
Acute Myeloid

scholarly journals Long Noncoding RNAs in Acute Myeloid Leukemia: Functional Characterization and Clinical Relevance

Cancers ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 1638 ◽  
Author(s):  
Morgane Gourvest ◽  
Pierre Brousset ◽  
Marina Bousquet
Keyword(s):  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Molecular Mechanisms ◽  
Functional Characterization ◽  
Noncoding Rnas ◽  
Genetic Alterations ◽  
Long Noncoding Rnas ◽  
Leukemic Cells ◽  
Protein Coding ◽  
Acute Myeloid

Acute Myeloid Leukemia (AML) is the most common form of leukemia in adults with an incidence of 4.3 per 100,000 cases per year. Historically, the identification of genetic alterations in AML focused on protein-coding genes to provide biomarkers and to understand the molecular complexity of AML. Despite these findings and because of the heterogeneity of this disease, questions as to the molecular mechanisms underlying AML development and progression remained unsolved. Recently, transcriptome-wide profiling approaches have uncovered a large family of long noncoding RNAs (lncRNAs). Larger than 200 nucleotides and with no apparent protein coding potential, lncRNAs could unveil a new set of players in AML development. Originally considered as dark matter, lncRNAs have critical roles to play in the different steps of gene expression and thus affect cellular homeostasis including proliferation, survival, differentiation, migration or genomic stability. Consequently, lncRNAs are found to be differentially expressed in tumors, notably in AML, and linked to the transformation of healthy cells into leukemic cells. In this review, we aim to summarize the knowledge concerning lncRNAs functions and implications in AML, with a particular emphasis on their prognostic and therapeutic potential.

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