scholarly journals The broad pathogenetic role of TCF7L2 in human diseases beyond type 2 diabetes

2021 ◽  
Author(s):  
Laura Bosque‐Plata ◽  
Eduardo Pavel Hernández‐Cortés ◽  
Claudia Gragnoli
Keyword(s):  
Type 2 Diabetes ◽  
Human Diseases ◽  
Pathogenetic Role

scholarly journals Pathogenetic role of intestinal dysbiosis in obesity and type 2 diabetes mellitus

2016 ◽  
Vol 0 (3 (55)) ◽  
pp. 82-90
Author(s):  
О. С. Ларін ◽  
С. М. Ткач ◽  
О. С. Тимошенко ◽  
Т. Ю. Юзвенко
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Pathogenetic Role ◽  
Intestinal Dysbiosis

GSK-3 Inhibitors: A Double-Edged Sword? – An Update on Tideglusib

Drug Research ◽  
2018 ◽  
Vol 68 (08) ◽  
pp. 436-443 ◽  
Author(s):  
Theodore Mathuram ◽  
Lisa Reece ◽  
Kotturathu Cherian
Keyword(s):  
Type 2 Diabetes ◽  
Regenerative Medicine ◽  
Human Diseases ◽  
Drug Candidate ◽  
Molecular Pathways ◽  
Pharmacological Effects ◽  
Combinational Therapy ◽  
Niche Area

AbstractGSK-3 inhibitors are an emerging tool for clinical interventions in human diseases and represent a niche area in combinational therapy. They possess diverse facets in applications of nervous system disorders, Type 2 diabetes, regenerative medicine and cancer. However, conflicting reports suggest the controversial role of GSK-3 inhibitors in cancers. This review aims to highlight the rise of GSK-3 inhibitors as tools for molecular-targeted research and its shift to a promising drug candidate. The review also focuses on key GSK-3 inhibitors and their roles in cancer and regenerative medicine with special emphasis to tideglusib. In addition, the decisive roles of GSK-3 in various molecular pathways will be concisely reviewed. Finally, this review concludes the emergence of GSK-3 inhibitors as a ‘double-edged sword’ in the treatment against human diseases cautioning researchers about the potential ramifications of off-target pharmacological effects.

The role of oncostatin m in the development of type 2 diabetes associated with obesity

2018 ◽  
Author(s):  
Siri Taxeras ◽  
Irene Piquer-Garcia ◽  
Silvia Pellitero ◽  
Rocio Puig ◽  
Eva Martinez ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Oncostatin M

1709-P: Assessing the Role of 211 “Established” Type 2 Diabetes Variants in American Indians

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1709-P
Author(s):  
ROBERT L. HANSON ◽  
LAUREN E. WEDEKIND ◽  
WEN-CHI HSUEH ◽  
SAYUKO KOBES ◽  
LESLIE J. BAIER ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
American Indians

1758-P: Type 2 Diabetes–Associated Mood Disorders: Role of Insulin Resistance in Serotonergic Neurons

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1758-P
Author(s):  
HUGO MARTIN ◽  
SÉBASTIEN BULLICH ◽  
FABIEN DUCROCQ ◽  
MARION GRALAND ◽  
CLARA OLIVRY ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Mood Disorders ◽  
Serotonergic Neurons ◽  
P Type
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