Roles of PLCβ, PIP 2 , and GIRK channels in arginine vasopressin‐elicited excitation of CA1 pyramidal neurons

2021 ◽  
Author(s):  
Binqi Hu ◽  
Cody A. Boyle ◽  
Saobo Lei
Keyword(s):  
Arginine Vasopressin ◽  
Pyramidal Neurons ◽  
Girk Channels ◽  
Ca1 Pyramidal Neurons

scholarly journals Association of Rgs7/Gβ5 complexes with girk channels and GABABreceptors in hippocampal CA1 pyramidal neurons

Hippocampus ◽  
2013 ◽  
Vol 23 (12) ◽  
pp. 1231-1245 ◽  
Author(s):  
Ana Fajardo-Serrano ◽  
Nicole Wydeven ◽  
Daniele Young ◽  
Masahiko Watanabe ◽  
Ryuichi Shigemoto ◽  
...  
Keyword(s):  
Pyramidal Neurons ◽  
Girk Channels ◽  
Ca1 Pyramidal Neurons ◽  
Hippocampal Ca1

scholarly journals Increased Calbindin D28k Expression via Long-Term Alternate-Day Fasting Does Not Protect against Ischemia-Reperfusion Injury: A Focus on Delayed Neuronal Death, Gliosis and Immunoglobulin G Leakage

2021 ◽  
Vol 22 (2) ◽  
pp. 644
Author(s):  
Hyejin Sim ◽  
Tae-Kyeong Lee ◽  
Yeon Ho Yoo ◽  
Ji Hyeon Ahn ◽  
Dae Won Kim ◽  
...  
Keyword(s):  
Immunoglobulin G ◽  
Pyramidal Neurons ◽  
Short Term Memory ◽  
Forebrain Ischemia ◽  
Short Term ◽  
Term Memory ◽  
Transient Forebrain Ischemia ◽  
Ca1 Pyramidal Neurons ◽  
Ca1 Region ◽  
Calbindin D28k

Calbindin-D28k (CB), a calcium-binding protein, mediates diverse neuronal functions. In this study, adult gerbils were fed a normal diet (ND) or exposed to intermittent fasting (IF) for three months, and were randomly assigned to sham or ischemia operated groups. Ischemic injury was induced by transient forebrain ischemia for 5 min. Short-term memory was examined via passive avoidance test. CB expression was investigated in the Cornu Ammonis 1 (CA1) region of the hippocampus via western blot analysis and immunohistochemistry. Finally, histological analysis was used to assess neuroprotection and gliosis (microgliosis and astrogliosis) in the CA1 region. Short-term memory did not vary significantly between ischemic gerbils with IF and those exposed to ND. CB expression was increased significantly in the CA1 pyramidal neurons of ischemic gerbils with IF compared with that of gerbils fed ND. However, the CB expression was significantly decreased in ischemic gerbils with IF, similarly to that of ischemic gerbils exposed to ND. The CA1 pyramidal neurons were not protected from ischemic injury in both groups, and gliosis (astrogliosis and microgliosis) was gradually increased with time after ischemia. In addition, immunoglobulin G was leaked into the CA1 parenchyma from blood vessels and gradually increased with time after ischemic insult in both groups. Taken together, our study suggests that IF for three months increases CB expression in hippocampal CA1 pyramidal neurons; however, the CA1 pyramidal neurons are not protected from transient forebrain ischemia. This failure in neuroprotection may be attributed to disruption of the blood–brain barrier, which triggers gliosis after ischemic insults.

Sign in / Sign up

Export Citation Format

Share Document