Roles of FAM134B in diseases from the perspectives of organelle membrane morphogenesis and cellular homeostasis

Mitochondrial hyperfusion: a friend or a foe

Biochemical Society Transactions ◽

10.1042/bst20190987 ◽

2020 ◽

Vol 48 (2) ◽

pp. 631-644 ◽

Cited By ~ 3

Author(s):

Rajdeep Das ◽

Oishee Chakrabarti

Keyword(s):

Negative Impact ◽

Cellular Stress ◽

Cellular Homeostasis ◽

Mitochondrial Population

The cellular mitochondrial population undergoes repeated cycles of fission and fusion to maintain its integrity, as well as overall cellular homeostasis. While equilibrium usually exists between the fission–fusion dynamics, their rates are influenced by organellar and cellular metabolic and pathogenic conditions. Under conditions of cellular stress, there is a disruption of this fission and fusion balance and mitochondria undergo either increased fusion, forming a hyperfused meshwork or excessive fission to counteract stress and remove damaged mitochondria via mitophagy. While some previous reports suggest that hyperfusion is initiated to ameliorate cellular stress, recent studies show its negative impact on cellular health in disease conditions. The exact mechanism of mitochondrial hyperfusion and its role in maintaining cellular health and homeostasis, however, remain unclear. In this review, we aim to highlight the different aspects of mitochondrial hyperfusion in either promoting or mitigating stress and also its role in immunity and diseases.

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Downregulation of Hemeoxygenase-1 and Altered Cellular Homeostasis in Cystic Fibrosis

Pneumologie ◽

10.1055/s-0034-1376792 ◽

2014 ◽

Vol 68 (06) ◽

Author(s):

SP Chillappagari ◽

S Venkatesan ◽

V Garapati ◽

P Mahavadi ◽

A Munder ◽

...

Keyword(s):

Cystic Fibrosis ◽

Cellular Homeostasis

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Looking Beyond Pattern Recognition: Perturbations in Cellular Homeostasis and Metabolism as Emerging Regulators of Dendritic Cell Function

10.3389/978-2-88963-228-2 ◽

2019 ◽

Keyword(s):

Pattern Recognition ◽

Dendritic Cell ◽

Cell Function ◽

Dendritic Cell Function ◽

Cellular Homeostasis

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Faculty Opinions recommendation of Regulated and polarized PtdIns(3,4,5)P3 accumulation is essential for apical membrane morphogenesis in photoreceptor epithelial cells.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1031003.363465 ◽

2006 ◽

Author(s):

Andreas Wodarz

Keyword(s):

Epithelial Cells ◽

Apical Membrane ◽

Membrane Morphogenesis

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Faculty Opinions recommendation of Sec14-nodulin proteins and the patterning of phosphoinositide landmarks for developmental control of membrane morphogenesis.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725375463.793504646 ◽

2016 ◽

Author(s):

Ivo Feussner

Keyword(s):

Developmental Control ◽

Membrane Morphogenesis

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Biological Activity of Trans-Membrane Anion Carriers

Current Medicinal Chemistry ◽

10.2174/0929867325666180309113222 ◽

2018 ◽

Vol 25 (30) ◽

pp. 3560-3576 ◽

Cited By ~ 3

Author(s):

Massimo Tosolini ◽

Paolo Pengo ◽

Paolo Tecilla

Keyword(s):

Biological Activity ◽

Membrane Transport ◽

Anticancer Agents ◽

Biological Effects ◽

Structure Activity Relationship ◽

New Drugs ◽

Activity Relationship ◽

Anion Channels ◽

Cellular Homeostasis ◽

Structure Activity

Natural and synthetic anionophores promote the trans-membrane transport of anions such as chloride and bicarbonate. This process may alter cellular homeostasis with possible effects on internal ions concentration and pH levels triggering several and diverse biological effects. In this article, an overview of the recent results on the study of aniontransporters, mainly acting with a carrier-type mechanism, is given with emphasis on the structure/activity relationship and on their biological activity as antibiotic and anticancer agents and in the development of new drugs for treating conditions derived from dysregulation of natural anion channels.

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