Silencing of long noncoding RNA MYLK‐AS1 suppresses nephroblastoma via down‐regulation of CCNE1 through transcription factor TCF7L2

2021 ◽  
Author(s):  
Shibo Zhu ◽  
Jingqi Zhang ◽  
Xiaofeng Gao ◽  
Xiangliang Tang ◽  
Yanhong Cui ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Down Regulation

scholarly journals The long noncoding RNA NEAT1 and nuclear paraspeckles are up-regulated by the transcription factor HSF1 in the heat shock response

2018 ◽  
Vol 293 (49) ◽  
pp. 18965-18976 ◽  
Author(s):  
S. Mohammad Lellahi ◽  
Ingrid Arctander Rosenlund ◽  
Annica Hedberg ◽  
Liv Torill Kiær ◽  
Ingvild Mikkola ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Heat Shock ◽  
Heat Shock Response ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Shock Response

scholarly journals Long Noncoding RNA MALAT1 Controls Cell Cycle Progression by Regulating the Expression of Oncogenic Transcription Factor B-MYB

PLoS Genetics ◽  
2013 ◽  
Vol 9 (3) ◽  
pp. e1003368 ◽  
Author(s):  
Vidisha Tripathi ◽  
Zhen Shen ◽  
Arindam Chakraborty ◽  
Sumanprava Giri ◽  
Susan M. Freier ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Transcription Factor ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Cell Cycle Progression ◽  
Cycle Progression ◽  
Factor B ◽  
Oncogenic Transcription Factor

Long noncoding RNA HBBP1 enhances γ-globin expression through the ETS transcription factor ELK1

2021 ◽  
Vol 552 ◽  
pp. 157-163
Author(s):  
Shuang-Ping Ma ◽  
Hai-Rui Xi ◽  
Xu-Xia Gao ◽  
Jing-Min Yang ◽  
Ryo Kurita ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Ets Transcription Factor

scholarly journals The cardiac lncRNA Chantico directly regulates Cxcl1 chemokine transcription

2021 ◽  
Author(s):  
Johnathon M Hall ◽  
Amoldeep S Kainth ◽  
Megan J Rowton ◽  
Emery Lu ◽  
Gabriela Haddad ◽  
...  
Keyword(s):  
Gene Regulation ◽  
Transcription Factor ◽  
Nucleic Acid ◽  
Immune Cells ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Premature Termination ◽  
Chemokine Gene ◽  
Cis Acting

In local gene regulation, long noncoding RNA (lncRNA) loci can function at three distinct, but non-mutually exclusive levels: the RNA molecule itself, the process of its transcription, and/or the underlying DNA element. Yet for cis-acting lncRNA, these distinctions are particularly challenging with present tools. To address this problem, we developed Omegazymes, catalytic nucleic acid enzymes to specifically target lncRNA for degradation without triggering premature termination of their transcription. We use Omegazymes to selectively target one of a highly refined set of lncRNAs in the mouse cardiomyocytes, demonstrating that the Chantico lncRNA molecule directly potentiates the transcription of Cxcl1, a neighboring chemokine gene. We find that the Chantico locus also acts at the DNA-level, as the binding of an essential cardiac transcription factor to the Chantico promoter is necessary for Cxcl1 transcription in mature cardiomyocytes. This Chantico regulation of Cxcl1 impacts cardiomyocyte signaling to immune cells, potentially regulating tissue-residence and inflammation.

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