scholarly journals Cancer‐associated mutations in the condensin II subunit CAPH2 cause genomic instability through telomere dysfunction and anaphase chromosome bridges

2020 ◽  
Author(s):  
Emily Weyburne ◽  
Giovanni Bosco
Keyword(s):  
Genomic Instability ◽  
Telomere Dysfunction ◽  
Chromosome Bridges

scholarly journals The role of telomere dysfunction in driving genomic instability

2007 ◽  
Vol 1299 ◽  
pp. 146-149
Author(s):  
Susan M. Bailey ◽  
Eli S. Williams ◽  
Robert L. Ullrich
Keyword(s):  
Genomic Instability ◽  
Telomere Dysfunction

scholarly journals Onset of Telomere Dysfunction and Fusions in Human Ovarian Carcinoma

Cells ◽  
2019 ◽  
Vol 8 (5) ◽  
pp. 414 ◽  
Author(s):  
Nazmul Huda ◽  
Yan Xu ◽  
Alison M. Bates ◽  
Deborah A. Rankin ◽  
Nagarajan Kannan ◽  
...  
Keyword(s):  
Genomic Instability ◽  
Critical Role ◽  
Telomerase Activity ◽  
Diagnostic Tools ◽  
Early Event ◽  
Molecular Heterogeneity ◽  
Telomere Dysfunction ◽  
Ovarian Carcinogenesis ◽  
Tumor Tissues ◽  
Human Solid Tumors

Telomere dysfunction has been strongly implicated in the initiation of genomic instability and is suspected to be an early event in the carcinogenesis of human solid tumors. Recent findings have established the presence of telomere fusions in human breast and prostate malignancies; however, the onset of this genomic instability mechanism during progression of other solid cancers is not well understood. Herein, we explored telomere dynamics in patient-derived epithelial ovarian cancers (OC), a malignancy characterized by multiple distinct subtypes, extensive molecular heterogeneity, and widespread genomic instability. We discovered a high frequency of telomere fusions in ovarian tumor tissues; however, limited telomere fusions were detected in normal adjacent tissues or benign ovarian samples. In addition, we found relatively high levels of both telomerase activity and hTERT expression, along with anaphase bridges in tumor tissues, which were notably absent in adjacent normal ovarian tissues and benign lesions. These results suggest that telomere dysfunction may occur early in ovarian carcinogenesis and, importantly, that it may play a critical role in the initiation and progression of the disease. Recognizing telomere dysfunction as a pervasive feature of this heterogeneous malignancy may facilitate the future development of novel diagnostic tools and improved methods of disease monitoring and treatment.

scholarly journals The Role of Telomere Dysfunction in Driving Genomic Instability

2009 ◽  
pp. 199-203
Author(s):  
Susan M. Bailey ◽  
Eli S. Williams ◽  
Robert L. Ullrich
Keyword(s):  
Genomic Instability ◽  
Telomere Dysfunction

Radiation-induced genomic instability triggered by telomere dysfunction

2003 ◽  
Vol 1258 ◽  
pp. 255-259
Author(s):  
Seiji Kodama ◽  
Ayumi Urushibara ◽  
Barkhaa Undarmaa ◽  
Naoki Mukaida ◽  
Keiji Suzuki ◽  
...  
Keyword(s):  
Genomic Instability ◽  
Telomere Dysfunction ◽  
Radiation Induced

Study of Telomere Dysfunction in TP53 Mutant LoVo Cell Lines as a Model for Genomic Instability

2018 ◽  
pp. 209-230 ◽  
Author(s):  
Oumar Samassekou ◽  
Nathalie Bastien ◽  
Ju Yan ◽  
Sabine Mai ◽  
Régen Drouin
Keyword(s):  
Genomic Instability ◽  
Cell Lines ◽  
Lovo Cell ◽  
Telomere Dysfunction

scholarly journals Telomere Dysfunction Increases Mutation Rate and Genomic Instability

Cell ◽  
2001 ◽  
Vol 106 (3) ◽  
pp. 275-286 ◽  
Author(s):  
Jennifer A. Hackett ◽  
David M. Feldser ◽  
Carol W. Greider
Keyword(s):  
Genomic Instability ◽  
Mutation Rate ◽  
Telomere Dysfunction

Involvement of telomere dysfunction in the induction of genomic instability by radiation in scid mouse cells

2004 ◽  
Vol 313 (4) ◽  
pp. 1037-1043 ◽  
Author(s):  
Ayumi Urushibara ◽  
Seiji Kodama ◽  
Keiji Suzuki ◽  
Mohamad Bin Md Desa ◽  
Fumio Suzuki ◽  
...  
Keyword(s):  
Genomic Instability ◽  
Scid Mouse ◽  
Telomere Dysfunction ◽  
Mouse Cells

scholarly journals End Resection Initiates Genomic Instability in the Absence of Telomerase

2003 ◽  
Vol 23 (23) ◽  
pp. 8450-8461 ◽  
Author(s):  
Jennifer A. Hackett ◽  
Carol W. Greider
Keyword(s):  
Genomic Instability ◽  
Loss Of Heterozygosity ◽  
Mutation Rate ◽  
Dicentric Chromosome ◽  
Telomere Dysfunction ◽  
Chromosome Fusion ◽  
Primary Mechanism ◽  
Chromosome Arm ◽  
End Resection

ABSTRACT Telomere dysfunction causes genomic instability. However, the mechanism that initiates this instability when telomeres become short is unclear. We measured the mutation rate and loss of heterozygosity along a chromosome arm in diploid yeast that lacked telomerase to distinguish between mechanisms for the initiation of instability. Sequence loss was localized near chromosome ends in the absence of telomerase but not after breakage of a dicentric chromosome. In the absence of telomerase, the increase in mutation rate is dependent on the exonuclease Exo1p. Thus, exonucleolytic end resection, rather than chromosome fusion and breakage, is the primary mechanism that initiates genomic instability when telomeres become short.

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