The impact of acute stress disorder on gallbladder interstitial cells of Cajal

2020 ◽  
Vol 235 (11) ◽  
pp. 8424-8431
Author(s):  
Zhen‐peng Huang ◽  
Hu Qiu ◽  
Ke Wang ◽  
Wei‐bo Chao ◽  
Hao‐bin Zhu ◽  
...  
Keyword(s):  
Interstitial Cells Of Cajal ◽  
Stress Disorder ◽  
Acute Stress ◽  
Acute Stress Disorder ◽  
Interstitial Cells ◽  
Cells Of Cajal ◽  
The Impact

Tu1311 THE EFFECT OF ACUTE STRESS DISORDER ON GALLBLADDER INTERSTITAL CELLS OF CAJAL

2020 ◽  
Vol 158 (6) ◽  
pp. S-1052-S-1053
Author(s):  
Zhenpeng Huang ◽  
Ke Wang ◽  
Hu Qiu ◽  
Baoping Yu
Keyword(s):  
Stress Disorder ◽  
Acute Stress ◽  
Acute Stress Disorder ◽  
Cells Of Cajal

Optimism, Satisfaction With Needs Met, Interpersonal Perceptions of the Healthcare Team, and Emotional Distress in Patients’ Family Members During Critical Care Hospitalization

2005 ◽  
Vol 14 (3) ◽  
pp. 202-210 ◽  
Author(s):  
Stephen M. Auerbach ◽  
Donald J. Kiesler ◽  
Jennifer Wartella ◽  
Sarah Rausch ◽  
Kevin R. Ward ◽  
...  
Keyword(s):  
Critical Care ◽  
Emotional Distress ◽  
Stress Disorder ◽  
Acute Stress ◽  
Family Members ◽  
Acute Stress Disorder ◽  
Brief Symptom Inventory ◽  
Family Needs ◽  
Healthcare Staff ◽  
The Impact

• Background Families of critical care patients experience high levels of emotional distress. Access to information about patients’ medical conditions and quality relationships with healthcare staff are high-priority needs for these families.• Objectives To assess satisfaction with needs met, signs and symptoms of acute stress disorder, interpersonal perception of healthcare staff, level of optimism, and the relationships among these variables in patients’ family members.• Methods Family representatives of 40 patients were administered a brief version of the Critical Care Family Needs Inventory, the Acute Stress Disorder Scale, the Brief Symptom Inventory, the Impact Message Inventory, and the Life Orientation Test shortly after admission of the patients to the intensive care unit and after discharge.• Results Levels of dissociative symptoms associated with acute stress disorder were elevated in family members just after admission but decreased significantly after discharge. Needs the families thought were least satisfactorily cared for after admission involved lack of information. Interpersonally, attending physicians were viewed as more controlling than bedside nurses at admission; nurses were viewed as more affiliative than physicians both at admission and after discharge. At admission, higher optimism of the family members was strongly related to greater satisfaction with needs met, to perceptions of affiliation from physicians, and to perceptions of not being controlled by physicians.• Conclusions More interpersonal contact with medical staff can help meet the information needs of patients’ families. Nurses may aid in families’ adjustment by fostering a sense of optimism in family members and encouraging them to participate in the patients’ care.

Effects of the EMDR Protocol for Recent Traumatic Events on Acute Stress Disorder: A Case Series

2014 ◽  
Vol 8 (1) ◽  
pp. 2-12 ◽  
Author(s):  
Sarah L. Buydens ◽  
Marshall Wilensky ◽  
Barbara J. Hensley
Keyword(s):  
Stress Disorder ◽  
Acute Stress ◽  
Traumatic Event ◽  
Effective Means ◽  
Traumatic Events ◽  
Case Series ◽  
Acute Stress Disorder ◽  
Subjective Distress ◽  
The Impact ◽  
Positive Results

The purpose of this study was to evaluate the effectiveness of the eye movement desensitization and reprocessing (EMDR) protocol for recent traumatic events in the treatment of acute stress disorder. Within weeks of being exposed to an isolated traumatic event, 7 adults diagnosed with acute stress disorder were provided with multiple sessions of the EMDR protocol for recent traumatic events, an extended version of the EMDR therapy standard protocol. In each case, an individual’s subjective distress caused by the traumatic events was measured using the Impact of Events Scale-Revised and the goal of alleviating symptoms was accomplished. The positive results suggest the EMDR protocol for recent traumatic events may be an effective means of providing early treatment to victims of trauma, potentially preventing the development of the more severe symptoms of posttraumatic stress disorder.

Changes in esophagus interstitial cells of Cajal in response to acute stress

2022 ◽  
pp. 1-9
Author(s):  
Zhen-peng Huang ◽  
Hu Qiu ◽  
Ke Wang ◽  
Jia-wei He ◽  
Hang Chen ◽  
...  
Keyword(s):  
Interstitial Cells Of Cajal ◽  
Acute Stress ◽  
Interstitial Cells ◽  
Cells Of Cajal

scholarly journals Mitochondrial calcium handling within the interstitial cells of Cajal

2014 ◽  
Vol 307 (1) ◽  
pp. G107-G121 ◽  
Author(s):  
Shawn A. Means ◽  
Leo K. Cheng
Keyword(s):  
Endoplasmic Reticulum ◽  
Interstitial Cells Of Cajal ◽  
Interstitial Cells ◽  
Calcium Handling ◽  
Intracellular Ca ◽  
Temporal Model ◽  
Model Geometry ◽  
Spatio Temporal ◽  
Cells Of Cajal ◽  
The Impact

The interstitial cells of Cajal (ICC) drive rhythmic pacemaking contractions in the gastrointestinal system. The ICC generate pacemaking signals by membrane depolarizations associated with the release of intracellular calcium (Ca2+) in the endoplasmic reticulum (ER) through inositol-trisphosphate (IP3) receptors (IP3R) and uptake by mitochondria (MT). This Ca2+ dynamic is hypothesized to generate pacemaking signals by calibrating ER Ca2+ store depletions and membrane depolarization with ER store-operated Ca2+ entry mechanisms. Using a biophysically based spatio-temporal model of integrated Ca2+ transport in the ICC, we determined the feasibility of ER depletion timescale correspondence with experimentally observed pacemaking frequencies while considering the impact of IP3R Ca2+ release and MT uptake on bulk cytosolic Ca2+ levels because persistent elevations of free intracellular Ca2+ are toxic to the cell. MT densities and distributions are varied in the model geometry to observe MT influence on free cytosolic Ca2+ and the resulting frequencies of ER Ca2+ store depletions, as well as the sarco-endoplasmic reticulum Ca2+ ATP-ase (SERCA) and IP3 agonist concentrations. Our simulations show that high MT densities observed in the ICC are more relevant to ER establishing Ca2+ depletion frequencies than protection of the cytosol from elevated free Ca2+, whereas the SERCA pump is more relevant to containing cytosolic Ca2+ elevations. Our results further suggest that the level of IP3 agonist stimulating ER Ca2+ release, subsequent MT uptake, and eventual activation of ER store-operated Ca2+ entry may determine frequencies of rhythmic pacemaking exhibited by the ICC across species and tissue types.

scholarly journals Gastric Electrical Stimulation Increases The Proliferation of Interstitial Cells of Cajal and Alters Enteric Nervous System in Diabetic Rats

2020 ◽  
Author(s):  
Cai Wang ◽  
Hui Zhang ◽  
Le Zhao ◽  
Tao Gao ◽  
Xia Liu ◽  
...  
Keyword(s):  
Nervous System ◽  
Electrical Stimulation ◽  
Enteric Nervous System ◽  
Interstitial Cells Of Cajal ◽  
Interstitial Cells ◽  
Diabetic Rats ◽  
Gastric Electrical Stimulation ◽  
Enteric Neurons ◽  
Cells Of Cajal ◽  
The Impact

Abstract Background: Lack of interstitial cells of Cajal (ICC) and neuropathy were the most possible pathological mechanisms of diabetic gastroparesis. Gastric electrical stimulation (GES) is a promising way to treat gastroparesis. The aims of the present study were to explore the impact of GES on ICC together with enteric neurons in diabetic rats and the possible mechanisms involved.Methods: Sixty rats were randomized into the normal rats, diabetic rats (DM), diabetic rats with sham GES (DM+SGES), and three diabetic rats with GES (DM+GES1, DM+GES2 and DM+GES3). The proliferation of ICC and expressions of 5-HT2B, nNOS, CHAT, PGP9.5 and GDNF were evaluated by immunofluorescence staining or Western blot. The expressions of 5-HT in blood and tissue were determined by ELISA.Results: (1) The proliferation of ICC was hardly observed in the DM group together with the DM+SGES group but increased in the three DM+GES groups. (2) The expression of 5-HT2B was decreased in the DM group and enhanced in the DM+GES groups. Similarly, the expressions of 5-HT in the blood and distal stomach tissue were increased in the DM+GES groups. (3) Both nNOS labeled neurons and CHAT positive neurons were reduced in myenteric plexus of the DM group, while plenty of these neurons were observed the DM+GES groups. (4) The expression of GDNF protein in the diabetic rats was down-regulated, while GES increased the expression of GDNF.Conclusion: GES improves the proliferation of ICC possibly related with 5-HT/5-HT2B signal pathway, and alters enteric nervous system 52 partly though the GDNF expression.

Sodium current in human small intestinal interstitial cells of cajal

2001 ◽  
Vol 120 (5) ◽  
pp. A201-A201 ◽  
Author(s):  
P STREGE ◽  
A RICH ◽  
Y OU ◽  
S GIBBONS ◽  
M SARR ◽  
...  
Keyword(s):  
Interstitial Cells Of Cajal ◽  
Sodium Current ◽  
Interstitial Cells ◽  
Small Intestinal ◽  
Cells Of Cajal
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