RNA m 6 A methylation regulates uveal melanoma cell proliferation, migration, and invasion by targeting c‐Met

2020 ◽  
Vol 235 (10) ◽  
pp. 7107-7119 ◽  
Author(s):  
Guangying Luo ◽  
Weiwei Xu ◽  
Yunping Zhao ◽  
Shanshan Jin ◽  
Siqi Wang ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Uveal Melanoma ◽  
Melanoma Cell ◽  
Migration And Invasion ◽  
Uveal Melanoma Cell ◽  
Melanoma Cell Proliferation

scholarly journals MiR-144 Inhibits Uveal Melanoma Cell Proliferation and Invasion by Regulating c-Met Expression

PLoS ONE ◽  
2015 ◽  
Vol 10 (5) ◽  
pp. e0124428 ◽  
Author(s):  
Lei Sun ◽  
Guangqing Bian ◽  
ZhaoJun Meng ◽  
Guangfu Dang ◽  
DeJing Shi ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Uveal Melanoma ◽  
Melanoma Cell ◽  
Uveal Melanoma Cell ◽  
Melanoma Cell Proliferation ◽  
Proliferation And Invasion

Effect of Arsenic Trioxide on Uveal Melanoma Cell Proliferation in vitro

2007 ◽  
Vol 39 (6) ◽  
pp. 302-307 ◽  
Author(s):  
Chunfang Wang ◽  
Bin Li ◽  
Haiyan Zhang ◽  
Guangpu Shi ◽  
Weihong Li ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Arsenic Trioxide ◽  
Uveal Melanoma ◽  
Melanoma Cell ◽  
Uveal Melanoma Cell ◽  
Melanoma Cell Proliferation ◽  
Proliferation In Vitro

The SDF-1/CXCR4 chemokine axis in uveal melanoma cell proliferation and migration

Tumor Biology ◽  
2015 ◽  
Vol 37 (3) ◽  
pp. 4175-4182 ◽  
Author(s):  
Jianjun Bi ◽  
Peng Li ◽  
Chuanyin Li ◽  
Jie He ◽  
Ying Wang ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Uveal Melanoma ◽  
Melanoma Cell ◽  
Cell Proliferation And Migration ◽  
Uveal Melanoma Cell ◽  
Melanoma Cell Proliferation ◽  
And Migration ◽  
Proliferation And Migration

scholarly journals Regulation of melanoma malignancy by the RP11-705C15.3/miR-145-5p/NRAS/MAPK signaling axis

2020 ◽  
Author(s):  
Xiang-jun Chen ◽  
Sha Liu ◽  
Dong-mei Han ◽  
De-zhi Han ◽  
Wei-jing Sun ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Melanoma Cell ◽  
Molecular Mechanisms ◽  
Ectopic Expression ◽  
Therapeutic Targets ◽  
Mapk Signaling ◽  
Migration And Invasion ◽  
Functional Assays ◽  
Melanoma Cell Proliferation ◽  
Signaling Axis

AbstractMelanoma is a common lethal skin cancer. Dissecting molecular mechanisms driving the malignancy of melanoma may uncover potential therapeutic targets. We previously identified miR-145-5p as an important tumor-suppressive microRNA in melanoma. Here, we further investigated the roles of long non-coding RNAs (lncRNAs) in melanoma. We identified RP11-705C15.3, a regulator of miR-145-5p, as an oncogenic lncRNA in melanoma. RP11-705C15.3 competitively bound miR-145-5p, relieved the repressive roles of miR-145-5p on its target NRAS, upregulated NRAS expression, and activated MAPK signaling. In vitro functional assays revealed that ectopic expression of RP11-705C15.3 promoted melanoma cell proliferation, inhibited apoptosis, and promoted migration and invasion. Silencing of RP11-705C15.3 repressed melanoma cell proliferation, induced apoptosis, and repressed migration and invasion. Notably, the roles of RP11-705C15.3 in melanoma cell proliferation, apoptosis, migration and invasion are reversed by miR-145-5p overexpression. In vivo functional assays revealed that RP11-705C15.3 promoted melanoma tumor growth and metastasis, which were also reversed by miR-145-5p overexpression. Furthermore, we investigated the expression of RP11-705C15.3 in clinical melanoma tissues and found that RP11-705C15.3 was increased in melanoma tissues. High expression of RP11-705C15.3 was positively correlated with thickness, ulceration, metastasis, and inferior overall survival. Taken together, our findings suggest RP11-705C15.3 as a novel oncogene in melanoma, and highlight that the RP11-705C15.3/miR-145-5p/NRAS/MAPK signaling axis may be potential therapeutic targets for melanoma.

scholarly journals Nck2 promotes human melanoma cell proliferation, migration and invasion in vitro and primary melanoma-derived tumor growth in vivo

BMC Cancer ◽  
2011 ◽  
Vol 11 (1) ◽  
Author(s):  
Mélissa Labelle-Côté ◽  
Julie Dusseault ◽  
Salma Ismaïl ◽  
Aude Picard-Cloutier ◽  
Peter M Siegel ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Tumor Growth ◽  
Melanoma Cell ◽  
Primary Melanoma ◽  
Human Melanoma ◽  
Human Melanoma Cell ◽  
Migration And Invasion ◽  
Melanoma Cell Proliferation
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