Vitamin D3 affects mitochondrial biogenesis through mitogen‐activated protein kinase in polycystic ovary syndrome mouse model

2020 ◽  
Vol 235 (9) ◽  
pp. 6113-6126
Author(s):  
Zahra Safaei ◽  
Shabnam Bakhshalizadeh ◽  
Mohammad Hossein Nasr‐Esfahani ◽  
Azadeh Akbari Sene ◽  
Vahid Najafzadeh ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Polycystic Ovary Syndrome ◽  
Mouse Model ◽  
Mitochondrial Biogenesis ◽  
Vitamin D3 ◽  
Polycystic Ovary ◽  
Mitogen Activated Protein Kinase ◽  
Ovary Syndrome ◽  
Mitogen Activated Protein

scholarly journals Evaluation of vitamin D3 in patients of polycystic ovary syndrome and their correlation

2017 ◽  
Vol 6 (5) ◽  
pp. 2010
Author(s):  
Rooplekha Chauhan ◽  
Sonal Sahani ◽  
Ankita Garg
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Vitamin D3 ◽  
Polycystic Ovary ◽  
Serum Vitamin ◽  
Reproductive Age ◽  
Ovary Syndrome ◽  
Chi Square ◽  
Exact Test ◽  
Young Females ◽  
Vitamin D3 Deficiency

Background: Polycystic ovary syndrome (PCOS) is enigma faced by young females since the onset of urbanization. As on day, PCOS is the most common endocrine disorder in the women of reproductive age affecting 4-10%. This study done to measure serum vitamin D3 levels of PCOS patients and to identify its association with factors associated with various symptoms and signs in PCOS.Methods: Institutional based prospective observational study conducted on 70 patients of PCOS, both suspected and already diagnosed, attending gynecology OPD of Department of obstetrics and gynecology of NSCB Medical College Jabalpur from 1 March 2015 to 31 August 2016. Diagnosis of PCOS was made by Rotterdam 2003 criteria. A detailed assessment was done and preformed proforma was filled. Serum Vitamin D3 levels were estimated by standard lab technique ‘Liquid Chromatography Tandem Mass Spectrometry’ and categorized into vitamin D3 sufficient >30ng/dl, insufficient 20-29ng/dl and deficient <20ng/dl. Categorical data was coded numerically before the analysis. For comparison of frequency distribution chi square test or fisher’s exact test were applied as appropriate.Results: Prevalence of Vitamin D3 deficiency in patients of PCOS was found to be 84.3%.Conclusions: The present study concludes that there is correlation between vitamin D3 and PCOS, screening and correction of vitamin D3 deficiency may prevent PCOS and its manifestations. Hence, it is speculated that improvement of vitamin D3 levels at a younger age can contribute to prevention of PCOS.

Myo‐inositol and D‐chiro‐inositol (40:1) reverse histological and functional features of polycystic ovary syndrome in a mouse model

2018 ◽  
Vol 234 (6) ◽  
pp. 9387-9398 ◽  
Author(s):  
Arturo Bevilacqua ◽  
Jessica Dragotto ◽  
Alessandro Giuliani ◽  
Mariano Bizzarri
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Mouse Model ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Functional Features

Evidence of an Inflammatory State in a Mouse Model of Polycystic Ovary Syndrome

2011 ◽  
pp. P3-387-P3-387
Author(s):  
Joseph S Marino ◽  
Abigail R Dowling ◽  
Xiaoliang Qiu ◽  
Laura Nedorezov ◽  
Laura FC Mueller ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Mouse Model ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Inflammatory State
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