Expression and clinicopathological significance of lipin‐1 in human breast cancer and its association with p53 tumor suppressor gene

2020 ◽  
Vol 235 (7-8) ◽  
pp. 5835-5846 ◽  
Author(s):  
Negar Dinarvand ◽  
Hossein Khanahmad ◽  
Sayyed Mohammadreza Hakimian ◽  
Abdolkarim Sheikhi ◽  
Bahman Rashidi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Human Breast Cancer ◽  
Suppressor Gene ◽  
Human Breast ◽  
P53 Tumor Suppressor ◽  
P53 Tumor Suppressor Gene ◽  
Clinicopathological Significance ◽  
Lipin 1

Mice Expressing a Mammary Gland–Specific R270H Mutation in the p53 Tumor Suppressor Gene Mimic Human Breast Cancer Development

2005 ◽  
Vol 65 (18) ◽  
pp. 8166-8173 ◽  
Author(s):  
Susan W.P. Wijnhoven ◽  
Edwin Zwart ◽  
Ewoud N. Speksnijder ◽  
Rudolf B. Beems ◽  
Kenneth P. Olive ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mammary Gland ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Human Breast Cancer ◽  
Suppressor Gene ◽  
Cancer Development ◽  
Human Breast ◽  
Breast Cancer Development ◽  
P53 Tumor Suppressor Gene

scholarly journals CDKN1C/p57kip2is a candidate tumor suppressor gene in human breast cancer

BMC Cancer ◽  
2008 ◽  
Vol 8 (1) ◽  
Author(s):  
Pamela S Larson ◽  
Benjamin L Schlechter ◽  
Chia-Lin King ◽  
Qiong Yang ◽  
Chelsea N Glass ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Human Breast Cancer ◽  
Suppressor Gene ◽  
Human Breast ◽  
Candidate Tumor Suppressor ◽  
Candidate Tumor Suppressor Gene

scholarly journals Methylation of the HIC-1 candidate tumor suppressor gene in human breast cancer

Oncogene ◽  
1998 ◽  
Vol 16 (16) ◽  
pp. 2159-2164 ◽  
Author(s):  
Hiroaki Fujii ◽  
Margaret A Biel ◽  
Weibo Zhou ◽  
Sigmund A Weitzman ◽  
Stephen B Baylin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Human Breast Cancer ◽  
Suppressor Gene ◽  
Human Breast ◽  
Candidate Tumor Suppressor ◽  
Candidate Tumor Suppressor Gene

Validation of p53 Immunohistochemistry as a Prognostic Factor in Breast Cancer in Clinical Practice

2002 ◽  
Vol 126 (4) ◽  
pp. 456-458 ◽  
Author(s):  
Angela N. Bartley ◽  
Dennis W. Ross
Keyword(s):  
Breast Cancer ◽  
Clinical Practice ◽  
Prognostic Factor ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
P53 Protein ◽  
Suppressor Gene ◽  
P53 Tumor Suppressor ◽  
P53 Tumor Suppressor Gene ◽  
P53 Immunohistochemistry

Abstract Context.—Abnormal p53 tumor suppressor gene expression as detected by immunohistochemistry is a possible prognostic factor in breast cancer. The difference in techniques used to evaluate the expression of mutated p53 protein is under intense scrutiny, as well as its uses either independently or in conjunction with other prognostic factors in breast cancer. Objective.—To determine whether p53 immunohistochemistry can be used as a reliable indicator of the presence of mutated nuclear p53 protein, and whether this method can be performed reliably in a community hospital's clinical practice. Design.—One hundred twenty-two cases of breast carcinoma were stained and analyzed for the presence of p53 protein using DO-7 (Dako Corporation, Carpinteria, Calif) p53 antibody. Results.—Of the 122 cases of invasive carcinoma studied, 23 (18.7%) were positive for p53, and 16 (16.3%) of 98 cases with coexisting ductal carcinoma in situ were positive for p53. This finding is in agreement with comparable published studies. Conclusions.—Based on the results of this study, we conclude that p53 immunohistochemistry qualifies as a diagnostic technique suitable for clinical practice in a community hospital. Its detection may be particularly promising in clinical trials of new molecular therapies directed at the p53 tumor suppressor gene.

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