Critical roles of long noncoding RNAs in breast cancer

2020 ◽  
Vol 235 (6) ◽  
pp. 5059-5071 ◽  
Author(s):  
Maryam Abolghasemi ◽  
Sadra S. Tehrani ◽  
Tooba Yousefi ◽  
Ansar Karimian ◽  
Ata Mahmoodpoor ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Noncoding Rnas ◽  
Long Noncoding Rnas

scholarly journals The Role of lncRNA in the Development of Tumors, Including Breast Cancer

2021 ◽  
Vol 22 (16) ◽  
pp. 8427
Author(s):  
Beata Smolarz ◽  
Anna Zadrożna-Nowak ◽  
Hanna Romanowicz
Keyword(s):  
Breast Cancer ◽  
Breast Carcinoma ◽  
Present Article ◽  
Noncoding Rnas ◽  
Long Noncoding Rnas ◽  
Regulation Of Transcription ◽  
Ribonucleic Acids ◽  
Detailed Review ◽  
Cellular Processes

Long noncoding RNAs (lncRNAs) are the largest groups of ribonucleic acids, but, despite the increasing amount of literature data, the least understood. Given the involvement of lncRNA in basic cellular processes, especially in the regulation of transcription, the role of these noncoding molecules seems to be of great importance for the proper functioning of the organism. Studies have shown a relationship between disturbed lncRNA expression and the pathogenesis of many diseases, including cancer. The present article presents a detailed review of the latest reports and data regarding the importance of lncRNA in the development of cancers, including breast carcinoma.

scholarly journals m6A-induced LINC00958 promotes breast cancer tumorigenesis via the miR-378a-3p/YY1 axis

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Dongwen Rong ◽  
Qian Dong ◽  
Huajun Qu ◽  
Xinna Deng ◽  
Fei Gao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Progression ◽  
Human Breast Cancer ◽  
Noncoding Rnas ◽  
Long Noncoding Rnas ◽  
Human Breast ◽  
Transcript Stability ◽  
Rna Transcript ◽  
Insight Into ◽  
Competitive Endogenous Rna

AbstractIncreasing evidence demonstrates that long noncoding RNAs (lncRNAs) play critical roles in human breast cancer (BC) tumorigenesis. However, the mechanisms by which lncRNA and N6-methyladenosine (m6A) regulate BC tumorigenesis are still unclear. In the present research, LINC00958 was markedly overexpressed in BC tissue and cells, and LINC00958 upregulation promoted the tumor progression of BC cells. Mechanistically, m6A methyltransferase-like 3 (METTL3) gave rise to the upregulation of LINC00958 by promoting its RNA transcript stability. Moreover, LINC00958 acted as a competitive endogenous RNA for miR-378a-3p to promote YY1. Overall, these data provide novel insight into how m6A-mediated LINC00958 regulates BC tumorigenesis.

scholarly journals Insights from Global Analyses of Long Noncoding RNAs in Breast Cancer

2017 ◽  
Vol 5 (1) ◽  
pp. 23-34 ◽  
Author(s):  
Andrew J. Warburton ◽  
David N. Boone
Keyword(s):  
Breast Cancer ◽  
Noncoding Rnas ◽  
Long Noncoding Rnas

scholarly journals Long Noncoding RNAs Involved in the Endocrine Therapy Resistance of Breast Cancer

Cancers ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1424 ◽  
Author(s):  
Toshihiko Takeiwa ◽  
Kazuhiro Ikeda ◽  
Yuichi Mitobe ◽  
Kuniko Horie-Inoue ◽  
Satoshi Inoue
Keyword(s):  
Breast Cancer ◽  
Endocrine Therapy ◽  
Noncoding Rnas ◽  
Therapeutic Targets ◽  
Therapy Resistance ◽  
Long Noncoding Rnas ◽  
Endocrine Therapy Resistance ◽  
New Biomarkers

Long noncoding RNAs (lncRNAs) are defined as RNAs longer than 200 nucleotides that do not encode proteins. Recent studies have demonstrated that numerous lncRNAs are expressed in humans and play key roles in the development of various types of cancers. Intriguingly, some lncRNAs have been demonstrated to be involved in endocrine therapy resistance for breast cancer through their own mechanisms, suggesting that lncRNAs could be promising new biomarkers and therapeutic targets of breast cancer. Here, we summarize the functions and mechanisms of lncRNAs related to the endocrine therapy resistance of breast cancer.

Abstract 1842: Identifying long noncoding RNAs in breast cancer microarrays.

2013 ◽  
Author(s):  
Hui Jia ◽  
Leonard Lipovich ◽  
Donghong Ju ◽  
Mary A. Kosir
Keyword(s):  
Breast Cancer ◽  
Noncoding Rnas ◽  
Long Noncoding Rnas

scholarly journals Identification of Long Noncoding RNAs as Predictors of Survival in Triple-Negative Breast Cancer Based on Network Analysis

2020 ◽  
Vol 2020 ◽  
pp. 1-15 ◽  
Author(s):  
Xiao-Xiao Li ◽  
Li-Juan Wang ◽  
Jie Hou ◽  
Hong-Yang Liu ◽  
Rui Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Network Analysis ◽  
Molecular Mechanisms ◽  
Triple Negative ◽  
Noncoding Rnas ◽  
Long Noncoding Rnas ◽  
Breast Cancers ◽  
Luminal A ◽  
Her2 Positive ◽  
Cancer Subtypes

Breast cancer is the most common cancer observed in adult females, worldwide. Due to the heterogeneity and varied molecular subtypes of breast cancer, the molecular mechanisms underlying carcinogenesis in different subtypes of breast cancer are distinct. Recently, long noncoding RNAs (lncRNAs) have been shown to be oncogenic or play important roles in cancer suppression and are used as biomarkers for diagnosis and therapy. In this study, we identified 134 lncRNAs and 6,414 coding genes were differentially expressed in triple-negative (TN), human epidermal growth factor receptor 2- (HER2-) positive, luminal A-positive, and luminal B-positive breast cancer. Of these, 37 lncRNAs were found to be dysregulated in all four subtypes of breast cancers. Subtypes of breast cancer special modules and lncRNA-mRNA interaction networks were constructed through weighted gene coexpression network analysis (WGCNA). Survival analysis of another public datasets was used to verify the identified lncRNAs exhibiting potential indicative roles in TN prognosis. Results from heat map analysis of the identified lncRNAs revealed that five blocks were significantly displayed. High expressions of lncRNAs, including LINC00911, CSMD2-AS1, LINC01192, SNHG19, DSCAM-AS1, PCAT4, ACVR28-AS1, and CNTFR-AS1, and low expressions of THAP9-AS1, MALAT1, TUG1, CAHM, FAM2011, NNT-AS1, COX10-AS1, and RPARP-AS1 were associated with low survival possibility in TN breast cancers. This study provides novel lncRNAs as potential biomarkers for the therapeutic and prognostic classification of different breast cancer subtypes.

scholarly journals Long noncoding RNAs in regulation of human breast cancer: Table 1

2015 ◽  
Vol 15 (3) ◽  
pp. 222-226 ◽  
Author(s):  
Guangxue Wang ◽  
Cuicui Liu ◽  
Shengqiong Deng ◽  
Qian Zhao ◽  
Tieyan Li ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Noncoding Rnas ◽  
Long Noncoding Rnas ◽  
Human Breast

Expression of long noncoding RNAs in breast cancer in relation to reproductive factors and tumor characteristics

2019 ◽  
Vol 120 (8) ◽  
pp. 13965-13973 ◽  
Author(s):  
Soudeh Ghafouri‐Fard ◽  
Mohammad Taheri ◽  
Mir Davood Omrani ◽  
Vahid Kholghi Oskooei
Keyword(s):  
Breast Cancer ◽  
Noncoding Rnas ◽  
Reproductive Factors ◽  
Long Noncoding Rnas ◽  
Tumor Characteristics

scholarly journals Epigenomics-based identification of oestrogen-regulated long noncoding RNAs in ER+ breast cancer

RNA Biology ◽  
2020 ◽  
Vol 17 (11) ◽  
pp. 1590-1602 ◽  
Author(s):  
Zhao Zhang ◽  
Wei Yu ◽  
Dan Tang ◽  
Yufan Zhou ◽  
Mingjun Bi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Noncoding Rnas ◽  
Long Noncoding Rnas
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