Cardioprotective effects of high‐intensity interval training are mediated through microRNA regulation of mitochondrial and oxidative stress pathways

2019 ◽  
Vol 235 (6) ◽  
pp. 5229-5240 ◽  
Author(s):  
Nevena Jeremic ◽  
Gregory J. Weber ◽  
Nicholas T. Theilen ◽  
Suresh C. Tyagi
Keyword(s):  
Oxidative Stress ◽  
High Intensity ◽  
Interval Training ◽  
High Intensity Interval Training ◽  
Microrna Regulation ◽  
Cardioprotective Effects ◽  
High Intensity Interval ◽  
And Oxidative Stress

scholarly journals High-intensity interval training modulates retinal microvascular phenotype and DNA methylation of p66Shc gene: a randomized controlled trial (EXAMIN AGE)

2019 ◽  
Vol 41 (15) ◽  
pp. 1514-1519 ◽  
Author(s):  
Lukas Streese ◽  
Abdul Waheed Khan ◽  
Arne Deiseroth ◽  
Shafaat Hussain ◽  
Rosa Suades ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Gene Expression ◽  
Dna Methylation ◽  
High Intensity ◽  
Interval Training ◽  
Retinal Vessel ◽  
High Intensity Interval Training ◽  
Age Related ◽  
High Intensity Interval ◽  
Retinal Arteriolar

Abstract Aims Impairments of retinal vessel diameter are associated with major adverse cardiovascular (CV) events. Promoter DNA methylation is a repressor of the mitochondrial adaptor p66Shc gene transcription, a key driver of ageing-induced reactive oxygen species. The study aimed to investigate whether high-intensity interval training (HIIT) affects retinal microvascular phenotype as well as p66Shc expression and oxidative stress in ageing subjects with increased CV risk from the EXAMIN AGE cohort. Methods and results Eighty-four sedentary subjects (mean age 59.4 ± 7.0 years) with ≥2 CV risk factors were randomized into either a 12-week HIIT or standard physical activity recommendations. Retinal arteriolar and venular diameters were measured by use of a retinal vessel analyser. As a marker of oxidative stress plasma 3-nitrotyrosine (3-NT) level was determined by ELISA. Gene expression of p66Shc and DNA methylation were assessed in mononuclear cells by RT-qPCR and methylated-DNA capture (MethylMiner Enrichment Kit) coupled with qPCR, respectively. High-intensity interval training reduced body mass index, fat mass, low-density lipoprotein and increased muscle mass, as well as maximal oxygen uptake (VO2max). Moreover, HIIT restored microvascular phenotype by inducing retinal arteriolar widening (pre: 175 ± 14 µm vs. post: 181 ± 13 µm, P = 0.001) and venular narrowing (pre: 222 ± 14 µm vs. post: 220 ± 14 µm, P = 0.007). After HIIT, restoration of p66Shc promoter methylation (P = 0.034) reduced p66Shc gene expression (P = 0.037) and, in turn, blunted 3-NT plasma levels (P = 0.002). Conclusion High-intensity interval training rescues microvascular dysfunction in ageing subjects at increased CV risk. Exercise-induced reprogramming of DNA methylation of p66Shc gene may represent a putative mechanistic link whereby exercise protects against age-related oxidative stress. Clinical trial registration  ClinicalTrials.gov: NCT02796976 (https://clinicaltrials.gov/ct2/show/NCT02796976).

scholarly journals Effects of high intensity interval training versus moderate intensity continuous training on the reduction of oxidative stress in type 2 diabetic adult patients: CAT

Medwave ◽  
2015 ◽  
Vol 15 (07) ◽  
pp. e6212-e6212 ◽  
Author(s):  
Carlos Emilio Poblete Aro ◽  
Javier Antonio Russell Guzmán ◽  
Marcelo Enrique Soto Muñoz ◽  
Bastián Eduardo Villegas González
Keyword(s):  
Oxidative Stress ◽  
High Intensity ◽  
Interval Training ◽  
Adult Patients ◽  
Moderate Intensity ◽  
High Intensity Interval Training ◽  
Continuous Training ◽  
High Intensity Interval ◽  
Type 2 Diabetic

Black Tea Extract Reduces DOMS, Oxidative Stress, and Cortisol Responses to High-Intensity Interval Training

2008 ◽  
Vol 40 (Supplement) ◽  
pp. S244
Author(s):  
Shawn M. Arent ◽  
Joseph Pellegrino ◽  
Meghan Senso ◽  
Kenneth H. McKeever ◽  
Anthony Lupinacci ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
High Intensity ◽  
Interval Training ◽  
Black Tea ◽  
High Intensity Interval Training ◽  
Black Tea Extract ◽  
Cortisol Responses ◽  
High Intensity Interval ◽  
Tea Extract

scholarly journals Impact of Modality and Intensity of Early Exercise Training on Ventricular Remodeling after Myocardial Infarction

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Diego Fernando Batista ◽  
Bertha Furlan Polegato ◽  
Renata Candido da Silva ◽  
Renan Turini Claro ◽  
Paula Shmidt Azevedo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Myocardial Infarction ◽  
Exercise Training ◽  
High Intensity ◽  
Interval Training ◽  
High Intensity Interval Training ◽  
Energetic Metabolism ◽  
Low Intensity ◽  
High Intensity Interval ◽  
Intensity Training

The objective of this study was to analyze the impact of different modalities and intensities of exercise training on cardiac remodeling started early after experimental myocardial infarction (MI). Male Wistar rats, weighing 200–250 g, were subjected to experimental MI. After 5 days, the animals were allocated into three experimental groups and observed for three months: S (sedentary control animals), C (animals subjected to continuous low-intensity training), and HIT (animals subjected to high-intensity interval training). Low-intensity exercise training was performed at a treadmill speed corresponding to 40% VO2 max, which was kept unchanged throughout the entire session (i.e., continuous low-intensity training). High-intensity interval training was performed in such a way that rats run during 3 min at 60% VO2 max, followed by 4-minute intervals at 85% VO2 max (i.e., high-intensity interval training). After the follow-up period, we studied hypertrophy and ventricular geometry, functional alterations in vivo and in vitro, oxidative stress, apoptosis, and cardiac energetic metabolism. Our data showed that both high-intensity interval and continuous low-intensity modalities improved cardiac energetic metabolism variables in comparison with sedentary infarcted animals. In addition, high-intensity interval training decreased cardiac oxidative stress, associated with improved diastolic function. On the other hand, the continuous low-intensity group showed impairment of cardiac function. Therefore, altogether, our data suggest that high-intensity interval training could be the best modality for early physical exercise after MI and should be better studied in this clinical scenario.

Comparison of sprint training and high intensity interval training on oxidative stress and aerobic capacity in male soccer players

2020 ◽  
Vol 16 (5) ◽  
pp. 357-366
Author(s):  
S. Perween ◽  
M.E. Hussain ◽  
I.I. Hejazi ◽  
M.Y.S. Siddiqui ◽  
A. Saif ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Aerobic Capacity ◽  
High Intensity ◽  
Interval Training ◽  
Soccer Players ◽  
Sprint Training ◽  
High Intensity Interval Training ◽  
Maximum Voluntary Isometric Contraction ◽  
Repeated Sprint ◽  
High Intensity Interval

The study compared the two popular modes of training: repeated sprint and interval, in terms of oxidative load and aerobic capacity. 20 male collegiate soccer players were assigned into either a repeated sprint training (RST) or high intensity interval training (HIIT) group. Training protocols were for a period of 4 weeks (3 times/week). Serum levels of superoxide dismutase, catalase and glutathione, in addition to maximal oxygen uptake and maximum voluntary isometric contraction for quadriceps and hamstrings were measured before training and within 24 h after the completion of training. Significant improvement (P≤0.05) in antioxidant defence response and leg strength was seen in both groups. However, improvement in aerobic capacity was non-significant in RST as compared to HIIT. These findings indicate that both RST and HIIT can be used as a conditioning exercise to alleviate exercise-induced oxidative stress in the competition phase in addition to improvement in aerobic capacity.

EFFECT OF FIO2 ON OXIDATIVE STRESS DURING HIGH-INTENSITY INTERVAL TRAINING AT MODERATE ALTITUDE

2003 ◽  
Vol 35 (Supplement 1) ◽  
pp. S116
Author(s):  
R L. Wilber ◽  
P L. Holm ◽  
D M. Morris ◽  
G M. Dallam ◽  
A W. Subudhi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
High Intensity ◽  
Interval Training ◽  
Moderate Altitude ◽  
High Intensity Interval Training ◽  
High Intensity Interval
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