Novel LRAP‐binding partner revealing the plasminogen activation system as a regulator of cementoblast differentiation and mineral nodule formation in vitro

2019 ◽  
Vol 235 (5) ◽  
pp. 4545-4558 ◽  
Author(s):  
Luciane Martins ◽  
Bruna Rabelo Amorim ◽  
Cristiane Ribeiro Salmon ◽  
Adriana Franco Paes Leme ◽  
Kamila Rosamilia Kantovitz ◽  
...  
Keyword(s):  
Nodule Formation ◽  
Plasminogen Activation ◽  
Binding Partner ◽  
Plasminogen Activation System ◽  
Activation System

Factors Involved In the Plasminogen Activation System in Human Breast Tumours

1994 ◽  
Vol 71 (05) ◽  
pp. 684-691 ◽  
Author(s):  
László Damjanovich ◽  
Csaba Turzó ◽  
Róza Ádány
Keyword(s):  
Epithelial Cells ◽  
Connective Tissue ◽  
Plasminogen Activators ◽  
Breast Tumour ◽  
Plasminogen Activation ◽  
Malignant Tumours ◽  
Plasminogen Activation System ◽  
Activation System ◽  
Malignant Breast ◽  
Pai 1

SummaryThe plasminogen activation system is a delicately balanced assembly of enzymes which seems to have primary influence on tumour progression. The conversion of plasminogen into serine protease plasmin with fibrinolytic activity depends on the actual balance between plasminogen activators (urokinase type; u-PA and tissue type; t-PA) and their inhibitors (type 1 and 2 plasminogen activator inhibitors; PAI-1 and PAI-2). The purpose of this study was to determine the exact histological localization of all the major factors involved in plasminogen activation, and activation inhibition (plasmin system) in benign and malignant breast tumour samples. Our results show that factors of the plasmin system are present both in benign and malignant tumours. Cancer cells strongly labelled for both u-PA and t-PA, but epithelial cells of fibroadenoma samples were also stained for plasminogen activators at least as intensively as tumour cells in cancerous tissues. In fibroadenomas, all the epithelial cells were labelled for PAM. Staining became sporadic in malignant tumours, cells located at the periphery of tumour cell clusters regularly did not show reaction for PAI-1. In the benign tumour samples the perialveolar connective tissue stroma contained a lot of PAI-1 positive cells, showing characteristics of fibroblasts; but their number was strongly decreased in the stroma of malignant tumours. These findings indicate that the higher level of u-PA antigen, detected in malignant breast tumour samples by biochemical techniques, does not necessarily indicate increased u-PA production by tumour cells but it might be owing to the increased number of cells producing u-PA as well. In malignant tumours PAI-1 seems to be decreased in the frontage of malignant cell invasion; i.e. malignant cells at the host/tumour interface do not express PAI-1 in morphologically detectable quantity and in the peritumoural connective tissue the number of fibroblasts containing PAI-1 is also decreased.

scholarly journals Different expression of the plasminogen activation system in renal thrombotic microangiopathy and the normal human kidney

1996 ◽  
Vol 50 (6) ◽  
pp. 2011-2019 ◽  
Author(s):  
Yichun Xu ◽  
Jacqueline Hagege ◽  
Béatrice Mougenot ◽  
Jean-Daniel Sraer ◽  
Ebbe Rønne ◽  
...  
Keyword(s):  
Thrombotic Microangiopathy ◽  
Human Kidney ◽  
Plasminogen Activation ◽  
Plasminogen Activation System ◽  
Normal Human Kidney ◽  
Activation System ◽  
Normal Human

Correlation of tissue and blood plasminogen activation system in breast cancer

2000 ◽  
Vol 150 (2) ◽  
pp. 137-145 ◽  
Author(s):  
Sun Young Rha ◽  
Woo Ick Yang ◽  
Soo Jung Gong ◽  
Jin Ju Kim ◽  
Nae Choon Yoo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Plasminogen Activation ◽  
Plasminogen Activation System ◽  
Activation System
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