c‐Fos separation from Lamin A/C by GDF15 promotes colon cancer invasion and metastasis in inflammatory microenvironment

2019 ◽  
Vol 235 (5) ◽  
pp. 4407-4421 ◽  
Author(s):  
Youxiang Ding ◽  
Kun Hao ◽  
Zhaohe Li ◽  
Rong Ma ◽  
You Zhou ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Invasion ◽  
Lamin A ◽  
Invasion And Metastasis ◽  
Inflammatory Microenvironment

scholarly journals Epigenetically regulated miR-145 suppresses colon cancer invasion and metastasis by targeting LASP1

Oncotarget ◽  
2016 ◽  
Vol 7 (42) ◽  
pp. 68674-68687 ◽  
Author(s):  
Wei Wang ◽  
Gang Ji ◽  
Xin Xiao ◽  
Xu Chen ◽  
Wei-Wei Qin ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Invasion ◽  
Invasion And Metastasis

Abstract 672: Differential effects of p53 mutations on cancer invasion and metastasis in a mouse model of colon cancer

2016 ◽  
Author(s):  
Ying Feng ◽  
Naoya Sakamoto ◽  
Maranne Green ◽  
Megan Greenn ◽  
Kathleen R. Cho ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Mouse Model ◽  
Cancer Invasion ◽  
P53 Mutations ◽  
Invasion And Metastasis ◽  
Differential Effects

scholarly journals Chemokine 25–induced signaling suppresses colon cancer invasion and metastasis

2012 ◽  
Vol 122 (9) ◽  
pp. 3184-3196 ◽  
Author(s):  
Huanhuan Joyce Chen ◽  
Robert Edwards ◽  
Serena Tucci ◽  
Pengcheng Bu ◽  
Jeff Milsom ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Invasion ◽  
Invasion And Metastasis

scholarly journals The Wnt Target Gene L1 in Colon Cancer Invasion and Metastasis

Cancers ◽  
2016 ◽  
Vol 8 (5) ◽  
pp. 48 ◽  
Author(s):  
Gal Haase ◽  
Nancy Gavert ◽  
Thomas Brabletz ◽  
Avri Ben-Ze’ev
Keyword(s):  
Colon Cancer ◽  
Target Gene ◽  
Cancer Invasion ◽  
Invasion And Metastasis

Abstract 5207: The chemokine 25 and chemokine receptor 9 axis suppresses colon cancer invasion and metastasis

2012 ◽  
Author(s):  
Huanhuan Chen ◽  
Serena Tucci ◽  
Zeynep Gümüs ◽  
Xiling Shen ◽  
Steven M. Lipkin
Keyword(s):  
Colon Cancer ◽  
Chemokine Receptor ◽  
Cancer Invasion ◽  
Invasion And Metastasis

Cinobufacini Inhibits Colon Cancer Invasion and Metastasis via Suppressing Wnt/β-Catenin Signaling Pathway and EMT

2020 ◽  
Vol 48 (03) ◽  
pp. 703-718 ◽  
Author(s):  
Jie Wang ◽  
Han Cai ◽  
Qiaoli Liu ◽  
Yue Xia ◽  
LiKai Xing ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Signaling Pathway ◽  
Cancer Invasion ◽  
In Vivo Studies ◽  
Colon Cancer Cells ◽  
Invasion And Metastasis ◽  
Invasion And Migration ◽  
And Migration

Cinobufacini is a well-known Chinese medicine extracted from Venenum Bufonis, also called Chan Su. It has been used clinically for various cancers, including colon cancer. However, the function of Cinobufacini on colon cancer invasion and metastasis, and its underlying molecular mechanism, is still not clear. In this study, we investigated the function and mechanism of Cinobufacini on colon cancer invasion and metastasis both in vitro and in vivo studies. Human colon cancer cells were cultured. CCK assay was used to detect the effect of Cinobufacini on colon cancer cells proliferation. The invasion and migration abilities were observed by transwell assays, and the expression of invasion and migration related genes MMP2, MMP9, and epithelial-to-mesenchymal transition (EMT) relate genes were observed by Western blot assays. An orthotopic xenograft model in nude mice was established using colon cancer HCT116 cells, and the function of Cinobufacini on colon cancer invasion and metastasis were observed in vivo. We found Cinobufacini significantly inhibited colon cancer cell proliferation in a dose/time-dependent manner; the invasion and migration abilities of colon cancer were decreased after treated with Cinobufacini. The metastasis and EMT related genes MMP9, MMP2, N-cadherin and Snail were obviously down-regulated, while the expression of E-cadherin was up-regulated after treatment with Cinobufacini. The Wnt/[Formula: see text]-catenin signaling pathway related genes were observed using WB,and results show that the expression of [Formula: see text]-catenin, wnt3a, c-myc, cyclin D1, and MMP7 were all down-regulated after being treated with cinobufacini, while the expression of APC was up-regulated. In vivo studies of the volume and weight of orthotopic xenograft tumors showed significantly shrinkage in the Cinobufacini group compared to the control group. The enterocoelia and liver metastasis tumors were significantly decreased, and the expression of MMP9, MMP2, and [Formula: see text]-catenin were also down-regulated, while E-cadherin was up-regulated in vivo after the treatment with Cinobufacini. Our data proves that Cinobufacini can inhibit colon cancer invasion and metastasis both in vitro and in vivo; the mechanism is related by suppressing the Wnt/[Formula: see text]-catenin signaling pathway and then inhibiting the EMT of CRC.

Sign in / Sign up

Export Citation Format

Share Document