lncrps25 play an essential role in motor neuron development through controlling the expression of olig2 in zebrafish

2019 ◽  
Vol 235 (4) ◽  
pp. 3485-3496 ◽  
Author(s):  
Tianheng Gao ◽  
Jingyun Li ◽  
Nan Li ◽  
Yan Gao ◽  
Lingling Yu ◽  
...  
Keyword(s):  
Motor Neuron ◽  
Essential Role ◽  
Neuron Development

scholarly journals MiR-375 is Essential for Human Spinal Motor Neuron Development and May Be Involved in Motor Neuron Degeneration

Stem Cells ◽  
2015 ◽  
Vol 34 (1) ◽  
pp. 124-134 ◽  
Author(s):  
Akshay Bhinge ◽  
Seema C. Namboori ◽  
Angela Bithell ◽  
Chiara Soldati ◽  
Noel J. Buckley ◽  
...  
Keyword(s):  
Motor Neuron ◽  
Neuron Development ◽  
Motor Neuron Degeneration ◽  
Neuron Degeneration ◽  
Spinal Motor Neuron ◽  
Spinal Motor

scholarly journals Insm1a Regulates Motor Neuron Development in Zebrafish

2017 ◽  
Vol 10 ◽  
Author(s):  
Jie Gong ◽  
Xin Wang ◽  
Chenwen Zhu ◽  
Xiaohua Dong ◽  
Qinxin Zhang ◽  
...  
Keyword(s):  
Motor Neuron ◽  
Neuron Development

Effects of metal exposure on motor neuron development, neuromasts and the escape response of zebrafish embryos

2015 ◽  
Vol 50 ◽  
pp. 33-42 ◽  
Author(s):  
Laura Sonnack ◽  
Sebastian Kampe ◽  
Elke Muth-Köhne ◽  
Lothar Erdinger ◽  
Nicole Henny ◽  
...  
Keyword(s):  
Motor Neuron ◽  
Escape Response ◽  
Metal Exposure ◽  
Zebrafish Embryos ◽  
Neuron Development

scholarly journals Isl1 Is required for multiple aspects of motor neuron development

2011 ◽  
Vol 47 (3) ◽  
pp. 215-222 ◽  
Author(s):  
Xingqun Liang ◽  
Mi-Ryoung Song ◽  
ZengGuang Xu ◽  
Guillermo M. Lanuza ◽  
Yali Liu ◽  
...  
Keyword(s):  
Motor Neuron ◽  
Neuron Development

scholarly journals Groucho/TLE opposes axial to hypaxial motor neuron development

2020 ◽  
Author(s):  
Adèle Salin-Cantegrel ◽  
Rola Dali ◽  
Jae Woong Wang ◽  
Marielle Beaulieu ◽  
Mira Deshmukh ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Motor Neuron ◽  
Motor Neurons ◽  
Molecular Mechanisms ◽  
List Type ◽  
Neuron Development ◽  
In Ovo ◽  
Motor Circuits ◽  
Axial Muscles ◽  
Muscle Innervation

ABSTRACTSpinal cord motor neuron diversity and the ensuing variety of motor circuits allow for the processing of elaborate muscular behaviours such as body posture and breathing. Little is known, however, about the molecular mechanisms behind the specification of axial and hypaxial motor neurons controlling postural and respiratory functions respectively. Here we show that the Groucho/TLE (TLE) transcriptional corepressor is a multi-step regulator of axial and hypaxial motor neuron diversification in the developing spinal cord. TLE first promotes axial motor neuron specification at the expense of hypaxial identity by cooperating with non-canonical WNT5A signalling within the motor neuron progenitor domain. TLE further acts during post-mitotic motor neuron diversification to promote axial motor neuron topology and axonal connectivity whilst suppressing hypaxial traits. These findings provide evidence for essential and sequential roles of TLE in the spatial and temporal coordination of events regulating the development of motor neurons influencing posture and controlling respiration.HIGHLIGHTSGroucho/TLE mediates non-canonical WNT signalling in developing motor neuronsNon canonical WNT:TLE pathway regulates thoracic motor neuron diversificationTLE promotes axial while inhibiting hypaxial motor neuron developmentTLE influences developing motor neuron topology and muscle innervationIN BRIEFSalin-Cantegrel et al use in ovo engineered approaches to show that a non-canonical WNT:TLE pathway coordinates temporally and spatially separated elements of motor neuron diversification, repressing hypaxial motor neuron development to promote the axial fate.GRAPHICAL ABSTRACTTLE contribution to the development of thoracic somatic motor columnsProgenitor cells in the ventral pMN domain are exposed to higher concentrations of non-canonical WNTs and express more TLE. Cooperation of non-canonical WNTs and TLE renders ventral pMN progenitors refractory to a respiratory MN fate, thereby contributing to the separation of MMC and RMC MN lineages. Differentiating MNs that maintain high TLE expression also maintain LHX3 expression, adopt axial motor neuron topology and connect to axial muscles. TLE activity in differentiating MMC MNs prevents the acquisition of respiratory MN topology and innervation traits.

scholarly journals Integrins Have Cell-Type-Specific Roles in the Development of Motor Neuron Connectivity

2019 ◽  
Vol 7 (3) ◽  
pp. 17 ◽  
Author(s):  
Devyn Oliver ◽  
Emily Norman ◽  
Heather Bates ◽  
Rachel Avard ◽  
Monika Rettler ◽  
...  
Keyword(s):  
Nervous System ◽  
Cell Adhesion ◽  
Motor Neuron ◽  
Motor Neurons ◽  
Neuron Development ◽  
Wild Type ◽  
Cell Type ◽  
C Elegans ◽  
Cell Type Specific ◽  
Two Phases

Formation of the nervous system requires a complex series of events including proper extension and guidance of neuronal axons and dendrites. Here we investigate the requirement for integrins, a class of transmembrane cell adhesion receptors, in regulating these processes across classes of C. elegans motor neurons. We show α integrin/ina-1 is expressed by both GABAergic and cholinergic motor neurons. Despite this, our analysis of hypomorphic ina-1(gm144) mutants indicates preferential involvement of α integrin/ina-1 in GABAergic commissural development, without obvious involvement in cholinergic commissural development. The defects in GABAergic commissures of ina-1(gm144) mutants included both premature termination and guidance errors and were reversed by expression of wild type ina-1 under control of the native ina-1 promoter. Our results also show that α integrin/ina-1 is important for proper outgrowth and guidance of commissures from both embryonic and post-embryonic born GABAergic motor neurons, indicating an ongoing requirement for integrin through two phases of GABAergic neuron development. Our findings provide insights into neuron-specific roles for integrin that would not be predicted based solely upon expression analysis.

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