miR125a attenuates BMSCs apoptosis via the MAPK‐ERK pathways in the setting of craniofacial defect reconstruction

2019 ◽  
Vol 235 (3) ◽  
pp. 2857-2865 ◽  
Author(s):  
Longkun Fan ◽  
Jingxian Wang ◽  
Chao Ma
Keyword(s):  
Defect Reconstruction ◽  
Craniofacial Defect

Step flap procedure for head defect reconstruction

2019 ◽  
Vol 3 (3) ◽  
Author(s):  
Roberto Cecchi ◽  
Imma Savarese ◽  
Laura Vanzi
Keyword(s):  
Defect Reconstruction ◽  
Flap Procedure

scholarly journals Bone defect reconstruction via endochondral ossification: A developmental engineering strategy

2021 ◽  
Vol 12 ◽  
pp. 204173142110042
Author(s):  
Rao Fu ◽  
Chuanqi Liu ◽  
Yuxin Yan ◽  
Qingfeng Li ◽  
Ru-Lin Huang
Keyword(s):  
Bone Regeneration ◽  
Bone Defect ◽  
Bone Repair ◽  
Endochondral Ossification ◽  
Current Knowledge ◽  
Endochondral Bone ◽  
Defect Reconstruction ◽  
Hypoxic Conditions ◽  
Bone Defect Reconstruction

Traditional bone tissue engineering (BTE) strategies induce direct bone-like matrix formation by mimicking the embryological process of intramembranous ossification. However, the clinical translation of these clinical strategies for bone repair is hampered by limited vascularization and poor bone regeneration after implantation in vivo. An alternative strategy for overcoming these drawbacks is engineering cartilaginous constructs by recapitulating the embryonic processes of endochondral ossification (ECO); these constructs have shown a unique ability to survive under hypoxic conditions as well as induce neovascularization and ossification. Such developmentally engineered constructs can act as transient biomimetic templates to facilitate bone regeneration in critical-sized defects. This review introduces the concept and mechanism of developmental BTE, explores the routes of endochondral bone graft engineering, highlights the current state of the art in large bone defect reconstruction via ECO-based strategies, and offers perspectives on the challenges and future directions of translating current knowledge from the bench to the bedside.

The Use of Perforator Flaps in Lower Extremity Traumatic Defect Reconstruction in the Pediatric Population

2017 ◽  
Vol 140 (4) ◽  
pp. 634e-636e ◽  
Author(s):  
Christian Herlin ◽  
Raphael Sinna ◽  
Farid Bekara ◽  
Marion Delpont ◽  
Swany Dast ◽  
...  
Keyword(s):  
Lower Extremity ◽  
Pediatric Population ◽  
Perforator Flaps ◽  
Defect Reconstruction

Total nasal defect reconstruction with nasal prosthesis. Two case reports

Stomatologiya ◽  
2021 ◽  
Vol 100 (4) ◽  
pp. 98
Author(s):  
K.A. Veselova ◽  
I.N. Antonova ◽  
N.V. Gromova
Keyword(s):  
Case Reports ◽  
Defect Reconstruction ◽  
Nasal Prosthesis ◽  
Nasal Defect
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