Toll‐like receptor 4 contributes to uterine activation by upregulating pro‐inflammatory cytokine and CAP expression via the NF‐κB/P38MAPK signaling pathway during pregnancy

2019 ◽  
Vol 235 (1) ◽  
pp. 513-525 ◽  
Author(s):  
Zixi Chen ◽  
Qiaoli Liu ◽  
Zhaowei Zhu ◽  
Fenfen Xiang ◽  
Rong Wu ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Inflammatory Cytokine ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
P38mapk Signaling

Effects of Amygdalin on TLR4/NF-αB Signaling Pathway-Mediated Proliferation and Apoptosis of Gastric Cancer Cells

2021 ◽  
Vol 20 (1) ◽  
pp. 153-158
Author(s):  
Abulajiang Abudoukelimu ◽  
Xinhui Yang ◽  
Lei Ge ◽  
Xiangyue Zeng ◽  
Yin Shu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
B Cell Lymphoma ◽  
Toll Like Receptor ◽  
Gastric Cancer Cells ◽  
Toll Like Receptor 4 ◽  
Proliferation And Apoptosis ◽  
High Incidence Rate ◽  
Factor Α

Gastric cancer is a highly malignant tumor of the digestive tract with high incidence rate and mortality. In the present study, we have shown decreased cell proliferation, increased apoptosis, and expression of proinflammatory cytokines (Interleukin-6, Interleukin-1β, and Tumor necrosis factor-α) in gastric cancer cells MGC-803 by amygdalin. Also, amygdalin treatment significantly reduced expression of the mRNA and protein for B-cell lymphoma 2 protein, CyclinD1, toll-like receptor 4, and REL-associated protein involved in NF-κB heterodimer formation in MGC-803 cells. In summary, amygdalin inhibits the proliferation of gastric cancer cells MGC-803 and promotes cell apoptosis by regulating the toll-like receptor 4/ nuclear factor-kappa B signaling pathway.

scholarly journals Cancer cell-derived long pentraxin 3 (PTX3) promotes melanoma migration through a toll-like receptor 4 (TLR4)/NF-κB signaling pathway

Oncogene ◽  
2019 ◽  
Vol 38 (30) ◽  
pp. 5873-5889 ◽  
Author(s):  
M. Rathore ◽  
C. Girard ◽  
M. Ohanna ◽  
M. Tichet ◽  
R. Ben Jouira ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Cancer Cell ◽  
Pentraxin 3 ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4
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