Knockdown of lncRNA NEAT1 inhibits Th17/CD4 + T cell differentiation through reducing the STAT3 protein level

2019 ◽  
Vol 234 (12) ◽  
pp. 22477-22484 ◽  
Author(s):  
Xiaolong Shui ◽  
Shaomin Chen ◽  
Jinti Lin ◽  
Jianzhong Kong ◽  
Chengwei Zhou ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
T Cell ◽  
Protein Level ◽  
T Cell Differentiation ◽  
Cd4 T Cell ◽  
Lncrna Neat1

scholarly journals The Cxxc1 subunit of the Trithorax complex directs epigenetic licensing of CD4+ T cell differentiation

2021 ◽  
Vol 218 (4) ◽  
Author(s):  
Masahiro Kiuchi ◽  
Atsushi Onodera ◽  
Kota Kokubo ◽  
Tomomi Ichikawa ◽  
Yuki Morimoto ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
T Cell ◽  
Allergic Airway Inflammation ◽  
T Cell Differentiation ◽  
Cd4 T Cell ◽  
Th2 Cells ◽  
Th2 Differentiation ◽  
Later Phase ◽  
Th1 And Th2

Different dynamics of gene expression are observed during cell differentiation. In T cells, genes that are turned on early or turned off and stay off have been thoroughly studied. However, genes that are initially turned off but then turned on again after stimulation has ceased have not been defined; they are obviously important, especially in the context of acute versus chronic inflammation. Using the Th1/Th2 differentiation paradigm, we found that the Cxxc1 subunit of the Trithorax complex directs transcription of genes initially down-regulated by TCR stimulation but up-regulated again in a later phase. The late up-regulation of these genes was impaired either by prolonged TCR stimulation or Cxxc1 deficiency, which led to decreased expression of Trib3 and Klf2 in Th1 and Th2 cells, respectively. Loss of Cxxc1 resulted in enhanced pathogenicity in allergic airway inflammation in vivo. Thus, Cxxc1 plays essential roles in the establishment of a proper CD4+ T cell immune system via epigenetic control of a specific set of genes.

scholarly journals End-stage renal disease, dialysis, kidney transplantation and their impact on CD4+T-cell differentiation

Immunology ◽  
2018 ◽  
Vol 155 (2) ◽  
pp. 211-224 ◽  
Author(s):  
Matthias Schaier ◽  
Angele Leick ◽  
Lorenz Uhlmann ◽  
Florian Kälble ◽  
Christian Morath ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Cell Differentiation ◽  
T Cell ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
T Cell Differentiation ◽  
Cd4 T Cell ◽  
Stage Renal Disease ◽  
End Stage

CD4 T-cell differentiation and inflammatory bowel disease

2009 ◽  
Vol 15 (5) ◽  
pp. 199-207 ◽  
Author(s):  
Lauren A. Zenewicz ◽  
Andrey Antov ◽  
Richard A. Flavell
Keyword(s):  
Inflammatory Bowel Disease ◽  
Cell Differentiation ◽  
T Cell ◽  
Bowel Disease ◽  
T Cell Differentiation ◽  
Cd4 T Cell ◽  
Inflammatory Bowel
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