Forkhead box o3a suppresses lipopolysaccharide‐stimulated proliferation and inflammation in fibroblast‐like synoviocytes through regulating tripartite motif‐containing protein 3

2019 ◽  
Vol 234 (11) ◽  
pp. 20139-20148 ◽  
Author(s):  
Mingjun Wang ◽  
Jian Wu ◽  
Erye Zhou ◽  
Xin Chang ◽  
Jianhe Gan ◽  
...  
Keyword(s):  
Forkhead Box ◽  
Tripartite Motif ◽  
Fibroblast Like Synoviocytes ◽  
Forkhead Box O3a

scholarly journals Hepcidin deficiency causes bone loss through interfering with the canonical Wnt/β-catenin pathway via Forkhead box O3a

2020 ◽  
Vol 23 ◽  
pp. 67-76 ◽  
Author(s):  
Guangfei Li ◽  
Hui Zhang ◽  
Jiadong Wu ◽  
Aifei Wang ◽  
Fan Yang ◽  
...  
Keyword(s):  
Bone Loss ◽  
Forkhead Box ◽  
Canonical Wnt ◽  
Forkhead Box O3a

scholarly journals Sex differences in forkhead box O3a signaling response to hindlimb unloading in rat soleus muscle

2018 ◽  
Vol 69 (2) ◽  
pp. 235-244 ◽  
Author(s):  
Toshinori Yoshihara ◽  
Toshiharu Natsume ◽  
Takamasa Tsuzuki ◽  
Shuo-wen Chang ◽  
Ryo Kakigi ◽  
...  
Keyword(s):  
Sex Differences ◽  
Soleus Muscle ◽  
Hindlimb Unloading ◽  
Forkhead Box ◽  
Rat Soleus Muscle ◽  
Forkhead Box O3a

scholarly journals MicroRNA-34c regulates porcine granulosa cell function by targeting forkhead box O3a

2017 ◽  
Vol 16 (9) ◽  
pp. 2019-2028
Author(s):  
Yuan XU ◽  
Ai-ling ZHANG ◽  
Zhe ZHANG ◽  
Xiao-long YUAN ◽  
Zan-mou CHEN ◽  
...  
Keyword(s):  
Granulosa Cell ◽  
Cell Function ◽  
Forkhead Box ◽  
Porcine Granulosa Cell ◽  
Forkhead Box O3a

scholarly journals Glucocorticoid (GC)-Mediated Down-Regulation of Urokinase Plasminogen Activator Expression via the Serum and GC Regulated Kinase-1/Forkhead Box O3a Pathway

Endocrinology ◽  
2008 ◽  
Vol 149 (5) ◽  
pp. 2637-2645 ◽  
Author(s):  
Travis Pew ◽  
Min Zou ◽  
Deanna R. Brickley ◽  
Suzanne D. Conzen
Keyword(s):  
Gene Expression ◽  
Plasminogen Activator ◽  
Target Genes ◽  
Urokinase Plasminogen Activator ◽  
Breast Cancer Cell Lines ◽  
Down Regulation ◽  
Forkhead Box ◽  
Breast Epithelial ◽  
Novel Target ◽  
Forkhead Box O3a

The glucocorticoid receptor (GR) and its ligand, cortisol, play a central role in human physiology. The exact mechanisms by which GR activation regulates these processes are the subject of intensive investigation. We and others have shown that GR activation can indirectly down-regulate specific genes via serum and glucocorticoid (GC) regulated kinase-1-mediated inhibition of forkhead box O3a (FOXO3a) transcriptional activity. We previously used gene expression microarrays, together with bioinformatic analyses, to identify putative FOXO3a target genes in breast epithelial cells. In this paper we refine our analysis through the use of FOXO3a chromatin immunoprecipitation (ChIP) microarrays. ChIP microarray results reveal urokinase plasminogen activator (uPA) as a putative novel target of FOXO3a in breast epithelial and breast cancer cell lines. We further show that uPA down-regulation after GC treatment requires serum and GC regulated kinase-1-mediated inactivation of FOXO3a activity. ChIP and luciferase assays confirm that FOXO3a can both occupy and transactivate the uPA promoter. Our data suggest that inactivation of FOXO3a after GR activation is an important mechanism contributing to GC-mediated repression of uPA gene expression in breast epithelial and cancer cells.

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