mTORC1 signaling activation increases intestinal stem cell activity and promotes epithelial cell proliferation

2019 ◽  
Vol 234 (10) ◽  
pp. 19028-19038 ◽  
Author(s):  
Jia‐Yi Zhou ◽  
Deng‐Gui Huang ◽  
Ying‐Chao Qin ◽  
Xiang‐Guang Li ◽  
Chun‐Qi Gao ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Epithelial Cell ◽  
Cell Activity ◽  
Intestinal Stem Cell ◽  
Epithelial Cell Proliferation ◽  
Mtorc1 Signaling ◽  
Stem Cell Activity ◽  
Signaling Activation

scholarly journals Dissociation of estrogen receptor expression and in vivo stem cell activity in the mammary gland

2006 ◽  
Vol 176 (1) ◽  
pp. 19-26 ◽  
Author(s):  
Katherine E. Sleeman ◽  
Howard Kendrick ◽  
David Robertson ◽  
Clare M. Isacke ◽  
Alan Ashworth ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Estrogen Receptor ◽  
Stem Cell ◽  
Epithelial Cell ◽  
Cell Activity ◽  
Mammary Stem Cell ◽  
Stem Cell Proliferation ◽  
Stem Cell Activity ◽  
Mammary Stem

The role of estrogen in promoting mammary stem cell proliferation remains controversial. It is unclear if estrogen receptor (ER)–expressing cells have stem/progenitor activity themselves or if they act in a paracrine fashion to stimulate stem cell proliferation. We have used flow cytometry to prospectively isolate mouse mammary ER-expressing epithelial cells and shown, using analysis of gene expression patterns and cell type–specific markers, that they form a distinct luminal epithelial cell subpopulation that expresses not only the ER but also the progesterone and prolactin receptors. Furthermore, we have used an in vivo functional transplantation assay to directly demonstrate that the ER-expressing luminal epithelial subpopulation contains little in vivo stem cell activity. Rather, the mammary stem cell activity is found within the basal mammary epithelial cell population. Therefore, ER-expressing cells of the mammary epithelium are distinct from the mammary stem cell population, and the effects of estrogen on mammary stem cells are likely to be mediated indirectly. These results are important for our understanding of cellular responses to hormonal stimulation in the normal breast and in breast cancer.

scholarly journals Signal integration by Ca2+ regulates intestinal stem-cell activity

Nature ◽  
2015 ◽  
Vol 528 (7581) ◽  
pp. 212-217 ◽  
Author(s):  
Hansong Deng ◽  
Akos A. Gerencser ◽  
Heinrich Jasper
Keyword(s):  
Stem Cell ◽  
Cell Activity ◽  
Intestinal Stem Cell ◽  
Signal Integration ◽  
Stem Cell Activity

scholarly journals Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila

2009 ◽  
Vol 23 (19) ◽  
pp. 2333-2344 ◽  
Author(s):  
N. Buchon ◽  
N. A. Broderick ◽  
S. Chakrabarti ◽  
B. Lemaitre
Keyword(s):  
Stem Cell ◽  
Cell Activity ◽  
Intestinal Stem Cell ◽  
Stem Cell Activity ◽  
Indigenous Microbiota

scholarly journals Limbal epithelial stem cell activity and corneal epithelial cell cycle parameters in adult and aging mice

2018 ◽  
Vol 33 ◽  
pp. 185-198 ◽  
Author(s):  
Nada Sagga ◽  
Lucia Kuffová ◽  
Neil Vargesson ◽  
Lynda Erskine ◽  
J. Martin Collinson
Keyword(s):  
Cell Cycle ◽  
Stem Cell ◽  
Epithelial Cell ◽  
Cell Activity ◽  
Corneal Epithelial Cell ◽  
Corneal Epithelial ◽  
Epithelial Stem Cell ◽  
Stem Cell Activity
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