Oxidative stress, inflammation, and glycometabolism disorder‐induced erythrocyte hemolysis in selenium‐deficient exudative diathesis broilers

2019 ◽  
Vol 234 (9) ◽  
pp. 16328-16337 ◽  
Author(s):  
Shufang Zheng ◽  
Jinxin Zhao ◽  
Houjuan Xing ◽  
Shiwen Xu
Keyword(s):  
Oxidative Stress ◽  
Exudative Diathesis ◽  
Erythrocyte Hemolysis

Enrichment of caffeic acid in peanut sprouts and evaluation of its in vitro effectiveness against oxidative stress-induced erythrocyte hemolysis

2017 ◽  
Vol 217 ◽  
pp. 332-341 ◽  
Author(s):  
Guang Wang ◽  
Zhuogui Lei ◽  
Qing Zhong ◽  
Wenjia Wu ◽  
Hong Zhang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Caffeic Acid ◽  
Erythrocyte Hemolysis

scholarly journals EXERCISE-INDUCED ALTERATIONS OF THE OXIDATIVE STRESS BIOMARKERS IN ERYTHROCYTESOF PONIES INVOLVED IN RECREATIONAL HORSEBACK RIDING

2020 ◽  
pp. 39-48
Author(s):  
Halyna Tkachenko ◽  
Natalia Kurhaluk ◽  
Iryna Tkachova
Keyword(s):  
Oxidative Stress ◽  
Training Session ◽  
Rest Period ◽  
Antioxidant Defenses ◽  
Exercise Session ◽  
Horseback Riding ◽  
Oxidative Stress Biomarkers ◽  
Jugular Veins ◽  
Erythrocyte Hemolysis ◽  
Stress Biomarkers

The aim of the current study was the analysis of the oxidative stress biomarkers, as well as the osmotic-induced resistance of erythrocytes in mares and stallions of ponies involved in recreational horseback riding in Pomeranian regions. Ten healthy adult Hucul ponies (5 stallions and 5 mares), 5-11 years old, from Pomeranian regions in Poland (Ustka city, Pomeranian Voivodship, Poland) were used in our study. All horses participated in recreational horseback riding and were subjected to the resembling type of management. The training was continued 1 hour and included a ride of cross country by walking (10 min), trotting (15 min), walking (10 min), galloping (15 min), and walking (10 min). Blood was drawn from jugular veins of the animals in the morning, 90 minutes after feeding, and immediately after the exercise session. Marker of lipid peroxidation (2-Thiobarbituric acid reactive substances, TBARS), aldehydic and ketonic derivatives in the erythrocytes, total antioxidant capacity (TAC) level in the erythrocytes of both mares and stallions exhibited non-significant changes immediately after exercise as compared to the resting period. Both at the rest and after the training session, the levels of TBARS, aldehydic and ketonic derivatives in the erythrocyte suspensions of mares were non-significantly higher compared to stallions. In a like manner, differences of aldehydic and ketonic derivatives of oxidatively modified proteins between mares and stallions after training sessions were noted. Both at the rest and after the training session, the TAC level in the erythrocyte suspensions of stallions was non-significantly higher compared to mares. Among both mares and stallions, a non-significantly decreased erythrocyte hemolysis was observed after training sessions compared to the rest period. A comparison of erythrocyte hemolysis in mares and stallions at the rest period showed increased values of hemolysis in the stallions. After the training session, decreased hemolysis was observed in the stallions compared to mares. Efforts should be directed toward a thorough characterization of antioxidant defenses, as well as the correlation links between oxidative stress biomarkers and antioxidant defenses including age- and gender-related differences in the training programs of horses involved in the recreational horseback ridings.

Lycopene alleviates sulfamethoxazole-induced hepatotoxicity in grass carp (Ctenopharyngodon idellus) via suppression of oxidative stress, inflammation and apoptosis

2020 ◽  
Vol 11 (10) ◽  
pp. 8547-8559
Author(s):  
Hongjing Zhao ◽  
Yu Wang ◽  
Mengyao Mu ◽  
Menghao Guo ◽  
Hongxian Yu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Secondary Metabolites ◽  
Human Health ◽  
Grass Carp ◽  
Aquatic Environment ◽  
Ctenopharyngodon Idellus

Antibiotics are used worldwide to treat diseases in humans and other animals; most of them and their secondary metabolites are discharged into the aquatic environment, posing a serious threat to human health.

Copper-dependent ATP7B up-regulation drives the resistance of TMEM16A-overexpressing head-and-neck cancer models to platinum toxicity

2019 ◽  
Vol 476 (24) ◽  
pp. 3705-3719 ◽  
Author(s):  
Avani Vyas ◽  
Umamaheswar Duvvuri ◽  
Kirill Kiselyov
Keyword(s):  
Oxidative Stress ◽  
Head And Neck ◽  
Transcriptional Activation ◽  
Platinum Resistance ◽  
Mrna Levels ◽  
Strong Positive Correlation ◽  
Platinum Compounds ◽  
Copper Chelation ◽  
Novel Approach ◽  
Cancer Models

Platinum-containing drugs such as cisplatin and carboplatin are routinely used for the treatment of many solid tumors including squamous cell carcinoma of the head and neck (SCCHN). However, SCCHN resistance to platinum compounds is well documented. The resistance to platinum has been linked to the activity of divalent transporter ATP7B, which pumps platinum from the cytoplasm into lysosomes, decreasing its concentration in the cytoplasm. Several cancer models show increased expression of ATP7B; however, the reason for such an increase is not known. Here we show a strong positive correlation between mRNA levels of TMEM16A and ATP7B in human SCCHN tumors. TMEM16A overexpression and depletion in SCCHN cell lines caused parallel changes in the ATP7B mRNA levels. The ATP7B increase in TMEM16A-overexpressing cells was reversed by suppression of NADPH oxidase 2 (NOX2), by the antioxidant N-Acetyl-Cysteine (NAC) and by copper chelation using cuprizone and bathocuproine sulphonate (BCS). Pretreatment with either chelator significantly increased cisplatin's sensitivity, particularly in the context of TMEM16A overexpression. We propose that increased oxidative stress in TMEM16A-overexpressing cells liberates the chelated copper in the cytoplasm, leading to the transcriptional activation of ATP7B expression. This, in turn, decreases the efficacy of platinum compounds by promoting their vesicular sequestration. We think that such a new explanation of the mechanism of SCCHN tumors’ platinum resistance identifies novel approach to treating these tumors.

Clinical aspects of reactive oxygen and nitrogen species

2004 ◽  
Vol 71 ◽  
pp. 121-133 ◽  
Author(s):  
Ascan Warnholtz ◽  
Maria Wendt ◽  
Michael August ◽  
Thomas Münzel
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Risk Factor ◽  
Endothelial Dysfunction ◽  
Vascular Tissue ◽  
Rapid Development ◽  
Reactive Oxygen ◽  
Clinical Aspects ◽  
No Production ◽  
Oxygen Species

Endothelial dysfunction in the setting of cardiovascular risk factors, such as hypercholesterolaemia, hypertension, diabetes mellitus and chronic smoking, as well as in the setting of heart failure, has been shown to be at least partly dependent on the production of reactive oxygen species in endothelial and/or smooth muscle cells and the adventitia, and the subsequent decrease in vascular bioavailability of NO. Superoxide-producing enzymes involved in increased oxidative stress within vascular tissue include NAD(P)H-oxidase, xanthine oxidase and endothelial nitric oxide synthase in an uncoupled state. Recent studies indicate that endothelial dysfunction of peripheral and coronary resistance and conductance vessels represents a strong and independent risk factor for future cardiovascular events. Ways to reduce endothelial dysfunction include risk-factor modification and treatment with substances that have been shown to reduce oxidative stress and, simultaneously, to stimulate endothelial NO production, such as inhibitors of angiotensin-converting enzyme or the statins. In contrast, in conditions where increased production of reactive oxygen species, such as superoxide, in vascular tissue is established, treatment with NO, e.g. via administration of nitroglycerin, results in a rapid development of endothelial dysfunction, which may worsen the prognosis in patients with established coronary artery disease.

Pancreatic stones shockwave lithotripsy induces oxidative stress. A study of lipoperoxidation products in pure pancreatic juice

2001 ◽  
Vol 120 (5) ◽  
pp. A217-A217
Author(s):  
C SPADA ◽  
S SANTINI ◽  
F FOSCHIA ◽  
M PANDOLFI ◽  
V PERRI ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Pancreatic Juice ◽  
Shockwave Lithotripsy ◽  
Pure Pancreatic Juice ◽  
Pancreatic Stones

Dilinoleoylphosphatidylcholine (DLPC) protects against alcohol-induced oxidative stress in rats

2001 ◽  
Vol 120 (5) ◽  
pp. A116-A116
Author(s):  
S ALEYNIK ◽  
M ALEYNIK ◽  
C LIEBER
Keyword(s):  
Oxidative Stress
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