PGC‐1α/SNAI1 axis regulates tumor growth and metastasis by targeting miR‐128b in gastric cancer

2019 ◽  
Vol 234 (10) ◽  
pp. 17232-17241 ◽  
Author(s):  
Ping Wang ◽  
Xueyan Guo ◽  
Wei Zong ◽  
Yulong Li ◽  
Guisheng Liu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Tumor Growth ◽  
Tumor Growth And Metastasis

scholarly journals Loss of MTUS1 in gastric cancer promotes tumor growth and metastasis

Neoplasma ◽  
2014 ◽  
Vol 61 (02) ◽  
pp. 128-135 ◽  
Author(s):  
X. Li ◽  
H. Liu ◽  
T. Yu ◽  
Z. Dong ◽  
L. Tang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Tumor Growth ◽  
Tumor Growth And Metastasis

scholarly journals miR-26a Suppresses Tumor Growth and Metastasis by Targeting FGF9 in Gastric Cancer

PLoS ONE ◽  
2013 ◽  
Vol 8 (8) ◽  
pp. e72662 ◽  
Author(s):  
Min Deng ◽  
Hai-lin Tang ◽  
Xi-hong Lu ◽  
Mei-yuan Liu ◽  
Xiao-min Lu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Tumor Growth ◽  
Tumor Growth And Metastasis

scholarly journals LINC00319 acts as a microRNA-335–5p sponge to accelerate tumor growth and metastasis in gastric cancer by upregulating ADCY3

2020 ◽  
Vol 318 (1) ◽  
pp. G10-G22
Author(s):  
Jun Zou ◽  
Kun Wu ◽  
Chao Lin ◽  
Zhi-Gang Jie
Keyword(s):  
Gastric Cancer ◽  
Adenylate Cyclase ◽  
Tumor Growth ◽  
Micro Rna ◽  
In Vivo Experiments ◽  
Tumorigenesis And Progression ◽  
Tumor Growth And Metastasis ◽  
And Migration

Gastric cancer (GC) is one of the most common cancers in the world and remains a heavy burden of health worldwide. Adenylate cyclase 3 ( ADCY3) is a widely expressed membrane-associated protein in human tissues and has been identified to be a new molecular target of GC. Long noncoding RNAs have a substantial influence on tumorigenesis and progression of tumors by binding to microRNAs. Therefore, this study is to clarify the mechanism by which LINC00319 sponges micro RNA-335–5p ( miR-335–5p) to influence the development of GC. Initially, microarray analysis identified GC-related differentially expressed LINC00319 and ADCY3 for this study. The interaction was confirmed that LINC00319 interacted with miR-335–5p to regulate ADCY3. Next, SGC-7901 cells presenting with the lowest LINC00319 expression and the highest miR-335–5p expression were transfected with LINC00319, miR-335–5p inhibitor, or ADCY3 vector to examine their roles in growth and metastasis of GC cells, which was further ascertained by in vivo experiments. LINC00319 was upregulated and miR-335–5p was downregulated in GC cells. LINC00319 overexpression, miR-335–5p inhibitor, or ADCY3 overexpression was shown to significantly elevate the expression of cyclin-dependent kinase 4 and metastasis associated 1, decrease that of growth arrest-specific 1, and promote tumor growth and metastasis by increasing proliferation and migration and reducing cell apoptosis. Importantly, it was found that overexpressed miR-335–5p exerted its tumor suppressive role in GC through downregulating ADCY3. Collectively, LINC00319 expedited growth and metastasis of GC by upregulating miR-335–5p-mediated ADCY3. NEW & NOTEWORTHY This study is carried out based on in vivo and in vitro studies in mice and gastric cancer (GC) cells with the aim of clarifying the role of LINC00319 on GC growth and metastasis, which associated with micro RNA-335–5p-mediated adenylate cyclase 3. Altogether, we identified LINC00319 to be a potential therapy to treat GC.

scholarly journals Nr5a2 promotes tumor growth and metastasis of gastric cancer AGS cells by Wnt/beta-catenin signaling

2019 ◽  
Vol Volume 12 ◽  
pp. 2891-2902 ◽  
Author(s):  
Lei Liu ◽  
Yan Li ◽  
Biran Pan ◽  
Tongtong Zhang ◽  
Danfeng Wei ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Tumor Growth ◽  
Beta Catenin ◽  
Ags Cells ◽  
Tumor Growth And Metastasis

scholarly journals The HIF-1A/miR-17-5p/PDCD4 axis contributes to the tumor growth and metastasis of gastric cancer

2020 ◽  
Vol 5 (1) ◽  
Author(s):  
Jiayu Zhao ◽  
Anqi Xiao ◽  
Chunyu Liu ◽  
Chao Ye ◽  
Kai Yin ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Tumor Growth ◽  
Tumor Growth And Metastasis

scholarly journals MicroRNA-22 inhibits tumor growth and metastasis in gastric cancer by directly targeting MMP14 and Snail

2015 ◽  
Vol 6 (11) ◽  
pp. e2000-e2000 ◽  
Author(s):  
Q-F Zuo ◽  
L-Y Cao ◽  
T Yu ◽  
L Gong ◽  
L-N Wang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Tumor Growth ◽  
Tumor Growth And Metastasis
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