Therapeutics for advanced hepatocellular carcinoma: Recent advances, current dilemma, and future directions

2019 ◽  
Vol 234 (8) ◽  
pp. 12122-12132 ◽  
Author(s):  
Jing Zhu ◽  
Tailang Yin ◽  
Yong Xu ◽  
Xiao‐Jie Lu
Keyword(s):  
Hepatocellular Carcinoma ◽  
Advanced Hepatocellular Carcinoma ◽  
Future Directions ◽  
Recent Advances

scholarly journals Current immunotherapeutic strategies in hepatocellular carcinoma: recent advances and future directions

2017 ◽  
Vol 10 (10) ◽  
pp. 805-814 ◽  
Author(s):  
Hwi Young Kim ◽  
Joong-Won Park
Keyword(s):  
Hepatocellular Carcinoma ◽  
Immune Responses ◽  
Cancer Vaccines ◽  
Immune Checkpoint Blockade ◽  
Recurrence Rates ◽  
Future Directions ◽  
Optimal Outcomes ◽  
Recent Advances ◽  
Promising Target ◽  
Tumor Stages

Hepatocellular carcinoma (HCC) is a common and serious health problem with high mortality. Treatment for HCC remains largely unsatisfactory owing to its high recurrence rates and frequent accompanying cirrhosis. In addition, the unique immune environment of the liver promotes tolerance, which, in conjunction with immune evasion by the disease, makes HCC a less promising target for conventional immunotherapy. However, recent advances in the immunotherapy have led to novel approaches to overcome these obstacles by manipulating and enhancing tumor-specific immune responses against HCC by using various modalities, such as cancer vaccines and immune checkpoint blockade. These treatments have shown both safety and promising outcomes in patients with HCC of various etiologies and tumor stages. Furthermore, combined strategies have been assessed to achieve optimal outcomes, by using immunotherapies with or without conventional treatments. This review briefly covers the background, recent advances, current issues, and future perspectives on immunotherapy in the field of HCC treatment.

scholarly journals Recent Advances in Systemic Therapies for Advanced Hepatocellular Carcinoma

2021 ◽  
Vol 20 (1) ◽  
pp. 23-33
Author(s):  
Gabriella Aitcheson ◽  
Anjana Pillai ◽  
Bassam Dahman ◽  
Binu V John
Keyword(s):  
Hepatocellular Carcinoma ◽  
Advanced Hepatocellular Carcinoma ◽  
Recent Advances ◽  
Systemic Therapies

scholarly journals New frontiers in endovascular therapies for locally advanced hepatocellular carcinoma

2021 ◽  
Vol 54 (2) ◽  
pp. 130-135
Author(s):  
Riccardo Inchingolo ◽  
Stavros Spiliopoulos ◽  
Alessandro Posa ◽  
Tiago Kojun Tibana ◽  
Thiago Franchi Nunes ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cause Of Death ◽  
State Of The Art ◽  
Locally Advanced ◽  
The State ◽  
Liver Tumour ◽  
Advanced Hepatocellular Carcinoma ◽  
Advanced Stage ◽  
Future Directions ◽  
Malignant Liver

Abstract Hepatocellular carcinoma is the most common primary malignant liver tumour and is a leading cause of death worldwide. Despite the advent of screening programmes, most cases of hepatocellular carcinoma are diagnosed late (in an advanced stage) which precludes curative treatments such as surgery and ablation. Therefore, intra-arterial locoregional treatments now play a central role in the management of advanced hepatocellular carcinoma, such treatments ranging from trans-arterial chemo-embolisation to the more recently developed trans-arterial radio-embolisation technique. In this essay, we discuss the state of the art of intra-arterial treatment for locally advanced hepatocellular carcinoma and the future directions for such treatment.

AFP, AFP-L3% and DCP levels in patients with advanced hepatocellular carcinoma treated with sorafenib

2009 ◽  
Vol 47 (01) ◽  
Author(s):  
H Schulze-Bergkamen ◽  
A Weinmann ◽  
M Wörns ◽  
PR Spies ◽  
A Teufel ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Advanced Hepatocellular Carcinoma
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