Long noncoding RNA Breast cancer antiestrogen resistance 4 is associated with cancer progression and its significant prognostic value

2018 ◽  
Vol 234 (8) ◽  
pp. 12956-12963 ◽  
Author(s):  
Wenqiu Zhao ◽  
Zhenlin Wang ◽  
Xiao Fang ◽  
Na Li ◽  
Jian Fang
Keyword(s):  
Breast Cancer ◽  
Cancer Progression ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Prognostic Value ◽  
Antiestrogen Resistance

scholarly journals ESR1-Stabilizing Long Noncoding RNA TMPO-AS1 Promotes Hormone-Refractory Breast Cancer Progression

2019 ◽  
Vol 39 (23) ◽  
Author(s):  
Yuichi Mitobe ◽  
Kazuhiro Ikeda ◽  
Takashi Suzuki ◽  
Kiyoshi Takagi ◽  
Hidetaka Kawabata ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Cancer Patients ◽  
Endocrine Therapy ◽  
Cancer Progression ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Breast Cancer Patients ◽  
Er Positive ◽  
Positive Breast Cancer

ABSTRACT Acquired endocrine therapy resistance is a significant clinical problem for breast cancer patients. In recent years, increasing attention has been paid to long noncoding RNA (lncRNA) as a critical modulator for cancer progression. Based on RNA-sequencing data of breast invasive carcinomas in The Cancer Genome Atlas database, we identified thymopoietin antisense transcript 1 (TMPO-AS1) as a functional lncRNA that significantly correlates with proliferative biomarkers. TMPO-AS1 positivity analyzed by in situ hybridization significantly correlates with poor prognosis of breast cancer patients. TMPO-AS1 expression was upregulated in endocrine therapy-resistant MCF-7 cells compared with levels in parental cells and was estrogen inducible. Gain and loss of TMPO-AS1 experiments showed that TMPO-AS1 promotes the proliferation and viability of estrogen receptor (ER)-positive breast cancer cells in vitro and in vivo. Global expression analysis using a microarray demonstrated that TMPO-AS1 is closely associated with the estrogen signaling pathway. TMPO-AS1 could positively regulate estrogen receptor 1 (ESR1) mRNA expression by stabilizing ESR1 mRNA through interaction with ESR1 mRNA. Enhanced expression of ESR1 mRNA by TMPO-AS1 could play a critical role in the proliferation of ER-positive breast cancer. Our findings provide a new insight into the understanding of molecular mechanisms underlying hormone-dependent breast cancer progression and endocrine resistance.

Long noncoding RNA DLX6-AS1 promotes breast cancer progression via miR-505-3p/RUNX2 axis

2019 ◽  
Vol 865 ◽  
pp. 172778 ◽  
Author(s):  
Ping Zhao ◽  
Haitao Guan ◽  
Zhijun Dai ◽  
Yuguang Ma ◽  
Yang Zhao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Progression ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Breast Cancer Progression

scholarly journals Long noncoding RNA LINC00899 suppresses breast cancer progression by inhibiting miR-425

Aging ◽  
2019 ◽  
Vol 11 (22) ◽  
pp. 10144-10153 ◽  
Author(s):  
Wenying Zhou ◽  
Jiao Gong ◽  
Yaqiong Chen ◽  
Jiahao Chen ◽  
Qi Zhuang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Progression ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Breast Cancer Progression

scholarly journals The prognostic value of long noncoding RNA HOTTIP on clinical outcomes in breast cancer

Oncotarget ◽  
2016 ◽  
Vol 8 (4) ◽  
pp. 6833-6844 ◽  
Author(s):  
Yinlong Yang ◽  
Jinxian Qian ◽  
Youqun Xiang ◽  
Yizuo Chen ◽  
Jinmiao Qu
Keyword(s):  
Breast Cancer ◽  
Clinical Outcomes ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Prognostic Value

scholarly journals Long noncoding RNA BHLHE40‐AS1 promotes early breast cancer progression through modulating IL‐6/STAT3 signaling

2020 ◽  
Vol 121 (7) ◽  
pp. 3465-3478 ◽  
Author(s):  
Rebecca S. DeVaux ◽  
Ali S. Ropri ◽  
Sandra L. Grimm ◽  
Peter A. Hall ◽  
Emilio O. Herrera ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Early Breast Cancer ◽  
Cancer Progression ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Breast Cancer Progression ◽  
Stat3 Signaling
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