T‐bet transcription factor in cardiovascular disease: Attenuation or inflammation factor?

2018 ◽  
Vol 234 (6) ◽  
pp. 7915-7922 ◽  
Author(s):  
Habib Haybar ◽  
Hadi Rezaeeyan ◽  
Mohammad Shahjahani ◽  
Reza Shirzad ◽  
Najmaldin Saki
Keyword(s):  
Cardiovascular Disease ◽  
Transcription Factor ◽  
Inflammation Factor

scholarly journals Nuclear Transcription Factor Kappa B (NF-кB) and Molecular Damage Mechanisms in Acute Cardiovascular Diseases. A Review

2018 ◽  
Vol 4 (2) ◽  
pp. 65-72 ◽  
Author(s):  
Roxana Buzas ◽  
Alexandru Florin Rogobete ◽  
Sonia Elena Popovici ◽  
Tudor Mateescu ◽  
Teodora Hoinoiu ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Transcription Factor ◽  
Cardiovascular Diseases ◽  
Molecular Mechanisms ◽  
Severe Form ◽  
Molecular Therapy ◽  
Atheromatous Plaque ◽  
Early Evaluation ◽  
Nuclear Transcription Factor ◽  
Molecular Damage

Abstract Worldwide, cardiovascular diseases (CVDs) represent one of the main causes of morbidity and mortality, and acute coronary syndromes are responsible for a large number of sudden cardiac deaths. One of the main challenges that still exist in this area is represented by the early detection and targeted monitoring of the pathophysiology involved in CVDs. During the last couple of years, researchers have highlighted the importance of molecular and epigenetic mechanisms involved in the initiation and augmentation of CVDs, culminating in their most severe form represented by acute myocardial infarction. One of the most studied molecular factors involved in this type of pathology is represented by nuclear transcription factor kappa B (NF-κB), as well as the involvement of microRNAs (miRNAs). It has been suggested that miRNAs can also be involved in the complex process of atheromatous plaque vulnerabilization that leads to an acute cardiac event. In this review paper, we describe the most important molecular mechanisms involved in the pathogenesis of CVDs and atheromatous plaque progression and vulnerabilization, which include molecular mechanisms dependent on NF-κB. For this paper, we used international databases (PubMed and Scopus). The keywords used for the search were “miRNAs biomarkers”, “miRNAs in cardiovascular disease”, “NF-κB in cardiovascular disease”, “molecular mechanism in cardiovascular disease”, and “myocardial NF-κB mechanisms”. Numerous molecular reactions that have NF-κB as a trigger are involved in the pathogenesis of CVDs. Moreover, miRNAs play an important role in initiating and aggravating certain segments of CVDs. Therefore, miRNAs can be used as biomarkers for early evaluation of CVDs. Furthermore, in the future, miRNAs could be used as a targeted molecular therapy in order to block certain mechanisms responsible for inducing CVDs and leading to acute cardiovascular events.

scholarly journals ETV2/ER71 Transcription Factor as a Therapeutic Vehicle for Cardiovascular Disease

Theranostics ◽  
2019 ◽  
Vol 9 (19) ◽  
pp. 5694-5705 ◽  
Author(s):  
Dong Hun Lee ◽  
Tae Min Kim ◽  
Joo Kyung Kim ◽  
Changwon Park
Keyword(s):  
Cardiovascular Disease ◽  
Transcription Factor

scholarly journals Systems Pharmacogenomics Finds RUNX1 Is an Aspirin-Responsive Transcription Factor Linked to Cardiovascular Disease and Colon Cancer

EBioMedicine ◽  
2016 ◽  
Vol 11 ◽  
pp. 157-164 ◽  
Author(s):  
Deepak Voora ◽  
A. Koneti Rao ◽  
Gauthami S. Jalagadugula ◽  
Rachel Myers ◽  
Emily Harris ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Colon Cancer ◽  
Transcription Factor

scholarly journals Ameliorative Effects of Transcription Factor Dfoxo Over-Expression in a Drosophila Cardiovascular Disease Model

2020 ◽  
Vol 118 (3) ◽  
pp. 453a
Author(s):  
Marissa Sumathipala ◽  
Meera C. Viswanathan ◽  
Anna C. Blice-Baum
Keyword(s):  
Cardiovascular Disease ◽  
Transcription Factor ◽  
Disease Model ◽  
Over Expression

NF-κB in Cardiovascular Disease: Diverse and Specific Effects of a "General" Transcription Factor?

2005 ◽  
Vol 5 (2) ◽  
pp. 183-202 ◽  
Author(s):  
W. Keith Jones ◽  
Maria Brown ◽  
Michael Wilhide ◽  
Suiwen He ◽  
Xiaoping Ren
Keyword(s):  
Cardiovascular Disease ◽  
Transcription Factor ◽  
Specific Effects ◽  
General Transcription Factor

scholarly journals Androgen receptor in human endothelial cells

2015 ◽  
Vol 224 (3) ◽  
pp. R131-R137 ◽  
Author(s):  
Verónica Torres-Estay ◽  
Daniela V Carreño ◽  
Ignacio F San Francisco ◽  
Paula Sotomayor ◽  
Alejandro S Godoy ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Endothelial Cells ◽  
Transcription Factor ◽  
Smooth Muscle ◽  
Androgen Receptor ◽  
Molecular Mechanisms ◽  
Biological Effects ◽  
Human Endothelial Cells ◽  
Retinoid Receptor ◽  
Wide Range

Androgen receptor (AR) is a ligand-inducible transcription factor, and a member of the steroid-thyroid-retinoid receptor superfamily, that mediates the biological effects of androgens in a wide range of physiological and pathological processes. AR expression was identified in vascular cells nearly 20 years ago, and recent research has shown that AR mediates a variety of actions of androgens in endothelial and vascular smooth muscle cells. In this mini-review, we review evidence indicating the importance of AR in human endothelial cell (HUVEC) homeostatic and pathogenic processes. Although a role for AR in the modulation of HUVEC biology is evident, the molecular mechanisms by which AR regulates HUVEC homeostasis and disease processes are not fully understood. Understanding these mechanisms could provide critical insights into the processes of pathogenesis of diseases ranging from cardiovascular disease to cancer that are major causes of human morbidity and mortality.

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