IRAK3 gene silencing prevents cardiac rupture and ventricular remodeling through negative regulation of the NF‐κB signaling pathway in a mouse model of acute myocardial infarction

2018 ◽  
Vol 234 (7) ◽  
pp. 11722-11733 ◽  
Author(s):  
Zhen‐Wei Ge ◽  
Bao‐Cai Wang ◽  
Jun‐Long Hu ◽  
Jun‐Jie Sun ◽  
Sheng Wang ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Mouse Model ◽  
Gene Silencing ◽  
Signaling Pathway ◽  
Ventricular Remodeling ◽  
Negative Regulation ◽  
Cardiac Rupture

Predictors of Left Ventricular Remodeling Post Acute Myocardial Infarction. Protocol for a Clinical Study

2019 ◽  
Vol 4 (3) ◽  
pp. 120-123
Author(s):  
Ioana Cîrneală ◽  
Diana Opincariu ◽  
István Kovács ◽  
Monica Chițu ◽  
Imre Benedek
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Acute Myocardial Infarction ◽  
Speckle Tracking ◽  
Ventricular Remodeling ◽  
Speckle Tracking Echocardiography ◽  
Left Ventricular Remodeling ◽  
Left Ventricular ◽  
Serum Biomarkers ◽  
Remodeling Index

Abstract Heart failure is a clinical syndrome that appears as a consequence of a structural disease, and the most common cause of left ventricular systolic dysfunction results from myocardial ischemia. Cardiac remodeling and neuroendocrine activation are the major compensatory mechanisms in heart failure. The main objective of the study is to identify the association between serum biomarkers illustrating the extent of myocardial necrosis (highly sensitive troponin as-says), left ventricular dysfunction (NT-proBNP), and systemic inflammatory response (illustrated via serum levels of hsCRP and interleukins) during the acute phase of a myocardial infarction, and the left ventricular remodeling process at 6 months following the acute event, quantified via speckle tracking echocardiography. The study will include 400 patients diagnosed with acute myocardial infarction without signs and symptoms of heart failure at the time of enrollment that will undergo a complex clinical examination and speckle tracking echocardiography. Serum samples from the peripheral blood will be collected in order to determine the inflammatory serum biomarkers. After 6 months, patients will be divided into 2 groups according to the development of ventricular remodeling, quantified by speckle tracking echocardiography: group 1 will consist of patients with a remodeling index lower than 15%, and group 2 will consist of patients with a remodeling index higher than 15%. All clinical and imaging data obtained at the baseline will be compared between these two groups in order to determine the features associated with a higher risk of deleterious ventricular remodeling and heart failure.

C-Reactive Protein as a Predictor of Infarct Expansion and Cardiac Rupture After a First Q-Wave Acute Myocardial Infarction

Circulation ◽  
1997 ◽  
Vol 96 (3) ◽  
pp. 778-784 ◽  
Author(s):  
Toshihisa Anzai ◽  
Tsutomu Yoshikawa ◽  
Hiroto Shiraki ◽  
Yasushi Asakura ◽  
Makoto Akaishi ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Cardiac Rupture ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Infarct Expansion ◽  
Q Wave

scholarly journals Predictors of early and late ventricular remodeling after acute myocardial infarction

1999 ◽  
Vol 22 (9) ◽  
pp. 581-586 ◽  
Author(s):  
Juan Sanchis ◽  
Luis D. Insa ◽  
Alberto Berenguer ◽  
Francisco J. Chorro ◽  
Angel Llácer ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Ventricular Remodeling

Cardiac Rupture in Acute Myocardial Infarction

2009 ◽  
Vol 205 (1-6) ◽  
pp. 11-16 ◽  
Author(s):  
Sten Rasmussen ◽  
Arne Leth ◽  
Erik Kjøller ◽  
Asger Pedersen
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Cardiac Rupture

Left Ventricular Remodeling and Systolic Deterioration in Acute Myocardial Infarction: Findings from the Stent-PAMI Study

2005 ◽  
Vol 18 (4) ◽  
pp. 255-260 ◽  
Author(s):  
STEPHEN J. MATTICHAK ◽  
KISHORE J. HARJAI ◽  
JACOB R. DUTCHER ◽  
JUDITH A. BOURA ◽  
GREGG STONE ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Ventricular Remodeling ◽  
Left Ventricular Remodeling ◽  
Left Ventricular
Sign in / Sign up

Export Citation Format

Share Document