Suppression of microRNA‐342‐3p increases glutamate transporters and prevents dopaminergic neuron loss through activating the Wnt signaling pathway via p21‐activated kinase 1 in mice with Parkinson's disease

2018 ◽  
Vol 234 (6) ◽  
pp. 9033-9044 ◽  
Author(s):  
Dong‐Mei Wu ◽  
Shan Wang ◽  
Xin Wen ◽  
Xin‐Rui Han ◽  
Yong‐Jian Wang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Wnt Signaling ◽  
Signaling Pathway ◽  
Dopaminergic Neuron ◽  
Wnt Signaling Pathway ◽  
Glutamate Transporters ◽  
Neuron Loss ◽  
P21 Activated Kinase ◽  
Dopaminergic Neuron Loss

scholarly journals Microbiome changes: an indicator of Parkinson’s disease?

2019 ◽  
Vol 8 (1) ◽  
Author(s):  
Caroline Haikal ◽  
Qian-Qian Chen ◽  
Jia-Yi Li
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Gut Microbiome ◽  
Dopaminergic Neuron ◽  
Alpha Synuclein ◽  
Neuron Loss ◽  
The Future ◽  
Dopaminergic Neuron Loss

AbstractParkinson’s disease is characterized by dopaminergic neuron loss and intracellular inclusions composed mainly of alpha synuclein (α-syn), but the mechanism of pathogenesis is still obscure. In recent years, more attention has been given to the gut as a key player in the initiation and progression of PD pathology. Several studies characterizing changes in the microbiome, particularly the gut microbiome, have been conducted. Although many studies found a decrease in the bacterial family Prevotellaceae and in butyrate-producing bacterial genera such as Roseburia and Faecalibacteria, and an increase in the genera Akkermansia many of the studies reported contradictory findings. In this review, we highlight the findings from the different studies and reflect on the future of microbiome studies in PD research.

scholarly journals Functional Rescue of Dopaminergic Neuron Loss in Parkinson's Disease Mice After Transplantation of Hematopoietic Stem and Progenitor Cells

EBioMedicine ◽  
2016 ◽  
Vol 8 ◽  
pp. 83-95 ◽  
Author(s):  
Wassim Altarche-Xifro ◽  
Umberto di Vicino ◽  
Maria Isabel Muñoz-Martin ◽  
Analía Bortolozzi ◽  
Jordi Bové ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Progenitor Cells ◽  
Dopaminergic Neuron ◽  
Hematopoietic Stem ◽  
Neuron Loss ◽  
Stem And Progenitor Cells ◽  
Dopaminergic Neuron Loss
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