Cerebroprotective effects of hydrogen sulfide in homocysteine‐induced neurovascular permeability: Involvement of oxidative stress, arginase, and matrix metalloproteinase‐9

2018 ◽  
Vol 234 (3) ◽  
pp. 3007-3019 ◽  
Author(s):  
Nibendu Nath ◽  
Himanshu Kishore Prasad ◽  
Munish Kumar
Keyword(s):  
Oxidative Stress ◽  
Hydrogen Sulfide ◽  
Matrix Metalloproteinase ◽  
Matrix Metalloproteinase 9 ◽  
Metalloproteinase 9

Matrix metalloproteinase-9 activity is associated to oxidative stress in patients with acute coronary syndrome

2010 ◽  
Vol 143 (1) ◽  
pp. 98-100 ◽  
Author(s):  
Alex Bittner ◽  
Hernán Alcaíno ◽  
Pablo F. Castro ◽  
Osvaldo Pérez ◽  
Ramón Corbalán ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Acute Coronary Syndrome ◽  
Matrix Metalloproteinase ◽  
Matrix Metalloproteinase 9 ◽  
Coronary Syndrome ◽  
Metalloproteinase 9

scholarly journals Hydrogen sulfide deficiency and diabetic renal remodeling: role of matrix metalloproteinase-9

2013 ◽  
Vol 304 (12) ◽  
pp. E1365-E1378 ◽  
Author(s):  
Sourav Kundu ◽  
Sathnur B. Pushpakumar ◽  
Aaron Tyagi ◽  
Denise Coley ◽  
Utpal Sen
Keyword(s):  
Hydrogen Sulfide ◽  
Matrix Metalloproteinase ◽  
Therapeutic Potential ◽  
Matrix Metalloproteinase 9 ◽  
Double Knockout ◽  
Diabetic Kidney ◽  
Connexin 40 ◽  
Akita Mice ◽  
Metalloproteinase 9

Matrix metalloproteinase-9 (MMP-9) causes adverse remodeling, whereas hydrogen sulfide (H2S) rescues organs in vascular diseases. The involvement of MMP-9 and H2S in diabetic renovascular remodeling is, however, not well characterized. We determined whether MMP-9 regulates H2S generation and whether H2S modulates connexin through N-methyl-d-aspartate receptor (NMDA-R)-mediated pathway in the diabetic kidney. Wild-type (WT, C57BL/6J), diabetic (Akita, C57BL/6J- Ins2 Akita), MMP-9−/− (M9KO), double knockout (DKO) of Akita/MMP-9−/− mice and in vitro cell culture were used in our study. Hyperglycemic Akita mice exhibited increased level of MMP-9 and decreased production of H2S. H2S-synthesizing enzymes cystathionine-β-synthase and cystathionine-γ-lyase were also diminished. In addition, increased expressions of NMDA-R1 and connexin-40 and -43 were observed in diabetic kidney. As expected, MMP-9 mRNA was not detected in M9KO kidneys. However, very thin protein expression and activity were detected. No other changes were noticed in M9KO kidney. In DKO mice, all the above molecules showed a trend toward baseline despite hyperglycemia. In vitro, glomerular endothelial cells treated with high glucose showed induction of MMP-9, attenuated H2S production, NMDA-R1 induction, and dysregulated conexin-40 and -43 expressions. Silencing MMP-9 by siRNA or inhibition of NMDA-R1 by MK801 or H2S treatment preserved connexin-40 and -43. We conclude that in diabetic renovascular remodeling MMP-9 plays a major role and that H2S has therapeutic potential to prevent adverse diabetic renal remodeling.

Role of matrix metalloproteinase-9 in chronic kidney disease: a new biomarker of resistant albuminuria

2016 ◽  
Vol 130 (7) ◽  
pp. 525-538 ◽  
Author(s):  
Helena Pulido-Olmo ◽  
Concha F. García-Prieto ◽  
Gloria Álvarez-Llamas ◽  
María G. Barderas ◽  
Fernando Vivanco ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Matrix Metalloproteinase ◽  
Matrix Metalloproteinase 9 ◽  
Metalloproteinase 9

Resistant albuminuria developed under chronic RAS blockade is strongly associated with increased circulating MMP-9 activity mediated by oxidative stress.

Nitrite or sildenafil, but not BAY 41-2272, blunt acute pulmonary embolism-induced increases in circulating matrix metalloproteinase-9 and oxidative stress

2009 ◽  
Vol 124 (3) ◽  
pp. 349-355 ◽  
Author(s):  
Carlos A. Dias-Junior ◽  
Stefany B.A. Cau ◽  
Alisson M. Oliveira ◽  
Michele M. Castro ◽  
Marcelo F. Montenegro ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Pulmonary Embolism ◽  
Matrix Metalloproteinase ◽  
Acute Pulmonary Embolism ◽  
Matrix Metalloproteinase 9 ◽  
Metalloproteinase 9 ◽  
And Oxidative Stress

scholarly journals Hydrogen sulfide mitigates matrix metalloproteinase-9 activity and neurovascular permeability in hyperhomocysteinemic mice

2010 ◽  
Vol 56 (2) ◽  
pp. 301-307 ◽  
Author(s):  
Neetu Tyagi ◽  
Srikanth Givvimani ◽  
Natia Qipshidze ◽  
Soumi Kundu ◽  
Shray Kapoor ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Matrix Metalloproteinase ◽  
Matrix Metalloproteinase 9 ◽  
Metalloproteinase 9
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