scholarly journals Exercise protects against diabetic cardiomyopathy by the inhibition of the endoplasmic reticulum stress pathway in rats

2018 ◽  
Vol 234 (2) ◽  
pp. 1682-1688 ◽  
Author(s):  
Wang Chengji ◽  
Fan Xianjin
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Diabetic Cardiomyopathy ◽  
Endoplasmic Reticulum Stress Pathway ◽  
Stress Pathway

scholarly journals The Sodium-Glucose Co-Transporter 2 Inhibitor, Empagliflozin, Protects against Diabetic Cardiomyopathy by Inhibition of the Endoplasmic Reticulum Stress Pathway

2017 ◽  
Vol 41 (6) ◽  
pp. 2503-2512 ◽  
Author(s):  
Yang Zhou ◽  
Wei Wu
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Diabetic Cardiomyopathy ◽  
Left Ventricular ◽  
High Dose ◽  
Mrna Levels ◽  
Caspase 12 ◽  
Endoplasmic Reticulum Stress Pathway ◽  
Systolic And Diastolic Function ◽  
Stress Pathway

Background/Aims: This study aimed to determine whether or not the sodium-glucose co-transporter 2 inhibitor, empagliflozin (EMPA), can protect against diabetic cardiomyopathy (DCM) and to elucidate the related mechanism. Methods: Rats were divided into the following four groups: a non-diabetic group; diabetic cardiomyopathy rats without EMPA treatment; and diabetic cardiomyopathy rats with EMPA treatment (low- and high-dose EMPA). Hemodynamic measurements were performed to evaluate left ventricular systolic and diastolic function. The histopathology of the heart was examined with hematoxylin-eosin staining. Expression of glucose-regulated protein (GRP)78, enhancer-binding protein homologous protein (CHOP), and caspase-12 was detected by Western blot, and the mRNA levels of XBP1, ATF4, and TRAF2 were analysed by real-time PCR. Results: EMPA significantly decreased the blood glucose level when compared with vehicle. EMPA strongly improved cardiac function based on hemodynamic and histopathologic analyses. Moreover, EMPA can significantly down-regulate the expression of GRP78, CHOP, and caspase-12 (P < 0.01). Additionally, the mRNA levels of XBP1, ATF4, and TRAF2 were markedly decreased by administration of EMPA (P < 0.01). Conclusion: EMPA protects against DCM by inactivating the endoplasmic reticulum stress pathway.

Sirt1 attenuates diabetic keratopathy by regulating the endoplasmic reticulum stress pathway

Life Sciences ◽  
2021 ◽  
Vol 265 ◽  
pp. 118789
Author(s):  
Shuang Wei ◽  
Jianwu Fan ◽  
Xin Zhang ◽  
Yaping Jiang ◽  
Siliang Zeng ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Endoplasmic Reticulum Stress Pathway ◽  
Stress Pathway ◽  
Diabetic Keratopathy
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