Ovarian cancer stem cell: A potential therapeutic target for overcoming multidrug resistance

2018 ◽  
Vol 234 (4) ◽  
pp. 3238-3253 ◽  
Author(s):  
Aynaz Mihanfar ◽  
Javad Aghazadeh Attari ◽  
Iraj Mohebbi ◽  
Maryam Majidinia ◽  
Mojtaba Kaviani ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Stem Cell ◽  
Multidrug Resistance ◽  
Cancer Stem Cell ◽  
Therapeutic Target ◽  
Potential Therapeutic Target

scholarly journals Histone Demethylase KDM4C Is Required for Ovarian Cancer Stem Cell Maintenance

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Guo-Qing Chen ◽  
Ping Ye ◽  
Rong-Song Ling ◽  
Fa Zeng ◽  
Xiong-Shan Zhu ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Histone Demethylase ◽  
Potential Therapeutic Target ◽  
Stem Cell Maintenance ◽  
Platinum Based Chemotherapy ◽  
Current Therapies ◽  
Sphere Formation

Ovarian cancer is a highly deadly disease, which is often diagnosed at a late stage with metastases. However, most ovarian cancers relapse after surgery combined with platinum-based chemotherapy. Cancer stem cells (CSCs) are stem-like cells that possess high tumorigenic capability and display higher resistant capability against current therapies. However, our knowledge of ovarian CSCs and their molecular mechanism remains sparse. In the current study, we found that KDM4C, a histone demethylase, was required for ovarian cancer stem cell (CSC) maintenance. Depletion of KDM4C significantly reduced the CSC population and sphere formation in vitro. Moreover, we found that KDM4C can regulate the expression of stem cell factor OCT-4 via binding to its promoter. These data indicate that KDM4C is relevant for ovarian CSC maintenance and underscore its importance as a potential therapeutic target.

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