scholarly journals Targeting the phosphatidylinositol 3-kinase/Akt/mechanistic target of rapamycin signaling pathway in B-lineage acute lymphoblastic leukemia: An update

2018 ◽  
Vol 233 (10) ◽  
pp. 6440-6454 ◽  
Author(s):  
Carolina Simioni ◽  
Alberto M. Martelli ◽  
Giorgio Zauli ◽  
Marco Vitale ◽  
James A. McCubrey ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Signaling Pathway ◽  
Lymphoblastic Leukemia ◽  
Target Of Rapamycin ◽  
Phosphatidylinositol 3 Kinase ◽  
Mechanistic Target Of Rapamycin ◽  
B Lineage ◽  
Phosphatidylinositol 3

Interaction between CD9 and PI3K‑p85 activates the PI3K/AKT signaling pathway in B‑lineage acute lymphoblastic leukemia

2021 ◽  
Vol 46 (1) ◽  
Author(s):  
Yi-Fen Shi ◽  
Zi-Yang Huang ◽  
Yi-Sha Huang ◽  
Ru-Jiao Dong ◽  
Chong-Yun Xing ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Signaling Pathway ◽  
Lymphoblastic Leukemia ◽  
Akt Signaling ◽  
Akt Signaling Pathway ◽  
B Lineage

scholarly journals Phosphatidylinositol 3-kinase inhibition potentiates glucocorticoid response in B-cell acute lymphoblastic leukemia

2017 ◽  
Vol 233 (3) ◽  
pp. 1796-1811 ◽  
Author(s):  
Cecilia Evangelisti ◽  
Alessandra Cappellini ◽  
Mariana Oliveira ◽  
Rita Fragoso ◽  
João T. Barata ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
B Cell ◽  
Lymphoblastic Leukemia ◽  
Phosphatidylinositol 3 Kinase ◽  
Kinase Inhibition ◽  
Glucocorticoid Response ◽  
Cell Acute Lymphoblastic Leukemia ◽  
Phosphatidylinositol 3

scholarly journals Phosphatidylinositol 3,5-bisphosphate plays a role in the activation and subcellular localization of mechanistic target of rapamycin 1

2012 ◽  
Vol 23 (15) ◽  
pp. 2955-2962 ◽  
Author(s):  
Dave Bridges ◽  
Jing-Tyan Ma ◽  
Sujin Park ◽  
Ken Inoki ◽  
Lois S. Weisman ◽  
...  
Keyword(s):  
Plasma Membrane ◽  
Subcellular Localization ◽  
Target Of Rapamycin ◽  
Class Iii ◽  
Cell Type ◽  
Phosphatidylinositol 3 Kinase ◽  
Mechanistic Target Of Rapamycin ◽  
Cell Type Specific ◽  
Stepwise Formation ◽  
Phosphatidylinositol 3

The kinase complex mechanistic target of rapamycin 1 (mTORC1) plays an important role in controlling growth and metabolism. We report here that the stepwise formation of phosphatidylinositol 3-phosphate (PI(3)P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) regulates the cell type–specific activation and localization of mTORC1. PI(3)P formation depends on the class II phosphatidylinositol 3-kinase (PI3K) PI3K-C2α, as well as the class III PI3K Vps34, while PI(3,5)P2 requires the phosphatidylinositol-3-phosphate-5-kinase PIKFYVE. In this paper, we show that PIKFYVE and PI3K-C2α are necessary for activation of mTORC1 and its translocation to the plasma membrane in 3T3-L1 adipocytes. Furthermore, the mTORC1 component Raptor directly interacts with PI(3,5)P2. Together these results suggest that PI(3,5)P2 is an essential mTORC1 regulator that defines the localization of the complex.

Sign in / Sign up

Export Citation Format

Share Document