LncRNA-PVT1 promotes pancreatic cancer cells proliferation and migration through acting as a molecular sponge to regulate miR-448

2017 ◽  
Vol 233 (5) ◽  
pp. 4044-4055 ◽  
Author(s):  
Liang Zhao ◽  
Hongru Kong ◽  
Hongwei Sun ◽  
Zongjing Chen ◽  
Bicheng Chen ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Pancreatic Cancer Cells ◽  
And Migration ◽  
Proliferation And Migration

MicroRNA-148a Suppresses the Proliferation and Migration of Pancreatic Cancer Cells by Down-regulating ErbB3

Pancreas ◽  
2016 ◽  
Vol 45 (9) ◽  
pp. 1263-1271 ◽  
Author(s):  
Hui Feng ◽  
Yalei Wang ◽  
Jiaojiao Su ◽  
Hongwei Liang ◽  
Chen-Yu Zhang ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Pancreatic Cancer Cells ◽  
And Migration ◽  
Proliferation And Migration

scholarly journals METTL3 Promotes Pancreatic Tumor Progression Through Regulating the miR-196a/CPEB3 Axis

2020 ◽  
Author(s):  
Pingping Ge ◽  
Dong Fan ◽  
Lei He ◽  
Qiong Wu ◽  
Jin Sun ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Tumor Progression ◽  
Cancer Cells ◽  
Pancreatic Tumor ◽  
Luciferase Reporter ◽  
Pancreatic Cancer Cells ◽  
And Migration ◽  
Proliferation And Migration

Abstract Background: Methyltransferase-like 3(METTL3)-mediated N6-methyladenosine (m6A) modification has been reported to regulate microRNAs maturation. Here, the study was designed to investigate the regulatory effect of m6A-dependent miRNA maturation on pancreatic cancer progression which is still limited before.Results: We found that METTL3 significantly upregulated in the pancreatic tumor tissues. Overexpression of METTL3 promoted cancer cell proliferation and migration in vitro and tumor progression in vivo. METTL3-mediated m6A modification facilitated miR-196a maturation in pancreatic cancer cells, and miR-196a increased the proliferation and migration of cancer cells in vitro. Luciferase reporter assay verified that cytoplasmic polyadenylation element binding protein 3 (CPEB3) was a direct target gene of miR-196a. In vivo studies proved that overexpression of miR-196a inhibited the anti-tumor effect of knockdown of METTL3, and overexpression of CPEB3 inhibited the miR-196a-enhanced tumor progression. Conclusions: We identified that METTL3 was upregulated in pancreatic cancer, leading to the upregulation of miR-196a, resulting in the downregulation of CPEB3, which promoted the pancreatic tumor progression. We first demonstrated that CPEB3 was a tumor suppressor gene in pancreatic cancer, and the METTL3 regulated miR-196a/CPEB3 axis may be a therapeutic target for pancreatic cancer therapy.

scholarly journals The Role of the Novel Selective Dual Inhibitor of the Igf-Ir/Ir on Proliferation and Migration of Human Pancreatic Cancer Cells

2013 ◽  
Vol 24 ◽  
pp. iv49
Author(s):  
Stephanie Booy ◽  
Casper Van Eijck ◽  
Peter Van Koetsveld ◽  
Fadime Dogan ◽  
Joop Janssen ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Human Pancreatic Cancer ◽  
The Novel ◽  
Dual Inhibitor ◽  
Pancreatic Cancer Cells ◽  
And Migration ◽  
Proliferation And Migration

scholarly journals RAGE Up-Regulation Differently Affects Cell Proliferation and Migration in Pancreatic Cancer Cells

2020 ◽  
Vol 21 (20) ◽  
pp. 7723
Author(s):  
Priyanka Swami ◽  
Swetha Thiyagarajan ◽  
Arianna Vidger ◽  
Venkata S. K. Indurthi ◽  
Stefan W. Vetter ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cell Proliferation ◽  
Cell Migration ◽  
Cancer Cells ◽  
Human Pancreatic Cancer ◽  
Mesenchymal Transition ◽  
Pancreatic Cancer Cells ◽  
Cell Proliferation And Migration ◽  
And Migration ◽  
Proliferation And Migration

The receptor for advanced glycation end products (RAGE) contributes to many cellular aspects of pancreatic cancer including cell proliferation, migration, and survival. Studies have shown that RAGE activation by its ligands promotes pancreatic tumor growth by stimulating both cell proliferation and migration. In this study, we investigated the effect of RAGE up-regulation on the proliferation and migration of the human pancreatic cancer Panc-1 cell-line. We show that moderate overexpression of RAGE in Panc-1 cells results in increased cell proliferation, but decreased cell migration. The observed cellular changes were confirmed to be RAGE-specific and reversible by using RAGE-specific siRNAs and the small molecule RAGE inhibitor FPS-ZM1. At the molecular level, we show that RAGE up-regulation was associated with decreased activity of FAK, Akt, Erk1/2, and NF-κB signaling pathways and greatly reduced levels of α2 and β1 integrin expression, which is in agreement with the observed decreases in cell migration. We also demonstrate that RAGE up-regulation changes the expression of key molecular markers of epithelial-to-mesenchymal transition (EMT). Our results suggest that in the absence of stimulation by external ligands, RAGE up-regulation can differently modulate cell proliferation and migration in pancreatic cancer cells and regulates partly EMT.

scholarly journals Deguelin inhibits proliferation and migration of human pancreatic cancer cells in vitro targeting hedgehog pathway

2016 ◽  
Vol 12 (4) ◽  
pp. 2761-2765 ◽  
Author(s):  
Wen Zheng ◽  
Shiliu Lu ◽  
Haolei Cai ◽  
Muxing Kang ◽  
Wenjie Qin ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Hedgehog Pathway ◽  
Human Pancreatic Cancer ◽  
Pancreatic Cancer Cells ◽  
And Migration ◽  
Proliferation And Migration
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