Gene and MicroRNA Expression Are Predictive of Tumor Response in Rectal Adenocarcinoma Patients Treated With Preoperative Chemoradiotherapy

2016 ◽  
Vol 232 (2) ◽  
pp. 426-435 ◽  
Author(s):  
Caterina Millino ◽  
Isacco Maretto ◽  
Beniamina Pacchioni ◽  
Maura Digito ◽  
Antonino De Paoli ◽  
...  
Keyword(s):  
Tumor Response ◽  
Rectal Adenocarcinoma ◽  
Preoperative Chemoradiotherapy ◽  
Microrna Expression

Search of Predictors of Radiosensitivity in Rectal Adenocarcinoma

2021 ◽  
Vol 66 (5) ◽  
pp. 39-44
Author(s):  
M. Vologirova ◽  
N. Volchenko ◽  
I. Zamulaeva ◽  
I. Droshneva ◽  
A. Boyko ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Tumor Regression ◽  
Rectal Adenocarcinoma ◽  
Treatment Method ◽  
Clinical Situation ◽  
Preoperative Chemoradiotherapy ◽  
Fourth Degree ◽  
Immunohistochemical Markers ◽  
Degree Of Differentiation ◽  
E Cadherin

Purpose: To analyze a number of immunohistochemical markers as predictors of the radiosensitivity of rectal adenocarcinoma. Material and methods: The study included 122 patients with histologically verified rectal adenocarcinoma, varying degrees of differentiation, and the stage of the tumor process I-IIIC, T2-T4b /N0-N2b/ M0, with the localization of the tumor in the lower-middle-ampullary parts of the rectum. Predictors included in the research: Ki67, p53, EGFR, Bcl2, COX2, P21, E-cadherin. Preoperative chemoradiotherapy was performed up to 48–50 Gy with the use of medications (5-FU, Cisplatin) as a radio modifiers. The analysis was carried out according to the degree of severity of therapeutic pathomorphosis (according to Mandard), a decrease in the stage before surgery. Results: A full course of preoperative chemoradiotherapy followed by surgery was performed at 121 patients, one patient died of concomitant cardiac pathology during the break. The first degree of Mandard pathomorphosis (complete resorption) registered at 12 patients. The second degree (preservation of a few tumor cells against the background of fibrotic changes) – at 27 patients. The third degree (a large number of preserved tumor cells against the background of the predominance of fibrosis) – at 38 patients. The fourth degree (tumor cells predominate over fibrotic changes) – at 27 patients. The fifth degree (complete absence of signs of tumor regression, absence of fibrosis) – at 2 patients. A decrease in the stage of the tumor process according to the preoperative comprehensive examination registered in 114 (94.2%) patients, in 9 (7.4%) patients – there was no dynamics. During the observation period from 2006 until nowadays, 10 people are known to have died. Years in remission range from 3 months to 22 years. According to the results of multivariate and multiple regression analyses, it is possible to successfully predict the effectiveness of chemoradiotherapy, both with the use of biomarkers (Ki67, p53, EGFR, Bcl2, COX2, P21, E-cadherin), and traditional indicators (histological type, stage of the disease, gender, degree of differentiation). It turned out, that both traditional indicators and immunohistochemical indicators work equally well, regardless of each other. Conclusion: Studied immunohistochemical predictors of radiosensitivity of rectal adenocarcinoma, allow to assess the degree of radiosensitivity or radioresistance of the tumor in each patient before the start of preoperative chemoradiotherapy by doing so, it warns us about the effectiveness or ineffectiveness of chemoradiotherapy in a specific clinical situation, which allows us to individualize the approach to treatment, choosing a more suitable treatment method for the patient: neoadjuvant chemotherapy or surgery.

Clinical Parameters Predicting Pathologic Tumor Response After Preoperative Chemoradiotherapy for Rectal Cancer

2007 ◽  
Vol 69 (4) ◽  
pp. 1167-1172 ◽  
Author(s):  
Sang Min Yoon ◽  
Dae Yong Kim ◽  
Tae Hyun Kim ◽  
Kyung Hae Jung ◽  
Hee Jin Chang ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Tumor Response ◽  
Preoperative Chemoradiotherapy ◽  
Clinical Parameters

Use of sequential endorectal US to predict the tumor response of preoperative chemoradiotherapy in rectal cancer

2017 ◽  
Vol 85 (3) ◽  
pp. 669-674 ◽  
Author(s):  
Ning Li ◽  
Lizhou Dou ◽  
Yueming Zhang ◽  
Jing Jin ◽  
Guiqi Wang ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Tumor Response ◽  
Preoperative Chemoradiotherapy
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