scholarly journals l-glutamine Improves Skeletal Muscle Cell Differentiation and Prevents Myotube Atrophy After Cytokine (TNF-α) Stress Via Reduced p38 MAPK Signal Transduction

2016 ◽  
Vol 231 (12) ◽  
pp. 2720-2732 ◽  
Author(s):  
Matthew Girven ◽  
Hannah F. Dugdale ◽  
Daniel J. Owens ◽  
David C. Hughes ◽  
Claire E. Stewart ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Signal Transduction ◽  
Cell Differentiation ◽  
P38 Mapk ◽  
Muscle Cell ◽  
Skeletal Muscle Cell ◽  
Muscle Cell Differentiation ◽  
Tnf Α

scholarly journals TNF-α and IGF1 modify the microRNA signature in skeletal muscle cell differentiation

2015 ◽  
Vol 13 (1) ◽  
pp. 4 ◽  
Author(s):  
Swanhild U Meyer ◽  
Christian Thirion ◽  
Anna Polesskaya ◽  
Stefan Bauersachs ◽  
Sebastian Kaiser ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Cell Differentiation ◽  
Muscle Cell ◽  
Skeletal Muscle Cell ◽  
Muscle Cell Differentiation ◽  
Tnf Α

scholarly journals MiR-17 and miR-19 cooperatively promote skeletal muscle cell differentiation

2019 ◽  
Vol 76 (24) ◽  
pp. 5041-5054 ◽  
Author(s):  
Delin Kong ◽  
Mei He ◽  
Lin Yang ◽  
Rongtao Zhou ◽  
Yun-Qin Yan ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Cell Differentiation ◽  
Muscle Cell ◽  
Skeletal Muscle Cell ◽  
Muscle Cell Differentiation

scholarly journals Smad7 Promotes and Enhances Skeletal Muscle Differentiation

2006 ◽  
Vol 26 (16) ◽  
pp. 6248-6260 ◽  
Author(s):  
Helen D. Kollias ◽  
Robert L. S. Perry ◽  
Tetsuaki Miyake ◽  
Arif Aziz ◽  
John C. McDermott
Keyword(s):  
Skeletal Muscle ◽  
Cell Differentiation ◽  
Muscle Cell ◽  
Muscle Differentiation ◽  
Skeletal Muscle Cell ◽  
Proximal Promoter ◽  
Cytokine Signaling ◽  
Skeletal Muscle Differentiation ◽  
Muscle Cell Differentiation ◽  
Tgf Β1

ABSTRACT Transforming growth factor β1 (TGF-β1) and myostatin signaling, mediated by the same Smad downstream effectors, potently repress skeletal muscle cell differentiation. Smad7 inhibits these cytokine signaling pathways. The role of Smad7 during skeletal muscle cell differentiation was assessed. In these studies, we document that increased expression of Smad7 abrogates myostatin- but not TGF-β1-mediated repression of myogenesis. Further, constitutive expression of exogenous Smad7 potently enhanced skeletal muscle differentiation and cellular hypertrophy. Conversely, targeting of endogenous Smad7 by small interfering RNA inhibited C2C12 muscle cell differentiation, indicating an essential role for Smad7 during myogenesis. Congruent with a role for Smad7 in myogenesis, we observed that the muscle regulatory factor (MyoD) binds to and transactivates the Smad7 proximal promoter region. Finally, we document that Smad7 directly interacts with MyoD and enhances MyoD transcriptional activity. Thus, Smad7 cooperates with MyoD, creating a positive loop to induce Smad7 expression and to promote MyoD driven myogenesis. Taken together, these data implicate Smad7 as a fundamental regulator of differentiation in skeletal muscle cells.

Prdx6 Prevents Diabetic Myopathy by Improving Skeletal Muscle Cell Differentiation

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1929-P
Author(s):  
FRANCESCA PACIFICI ◽  
BARBARA CAPUANI ◽  
FRANCESCA PIERMARINI ◽  
DONATELLA PASTORE ◽  
ROBERTO ARRIGA ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Cell Differentiation ◽  
Muscle Cell ◽  
Skeletal Muscle Cell ◽  
Muscle Cell Differentiation
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