Bone Morphogenetic Protein-2 Antagonizes Bone Morphogenetic Protein-4 Induced Cardiomyocyte Hypertrophy and Apoptosis

2014 ◽  
Vol 229 (10) ◽  
pp. 1503-1510 ◽  
Author(s):  
Jing Lu ◽  
Bo Sun ◽  
Rong Huo ◽  
Yu-Chun Wang ◽  
Di Yang ◽  
...  
Keyword(s):  
Bone Morphogenetic Protein ◽  
Bone Morphogenetic Protein 2 ◽  
Cardiomyocyte Hypertrophy ◽  
Bone Morphogenetic Protein 4 ◽  
Morphogenetic Protein

A New Way to Accelerate the Distraction of the Transpalatal Suture in Growing Dogs Using Recombinant Human Bone Morphogenetic Protein-2

2017 ◽  
Vol 54 (2) ◽  
pp. 193-201 ◽  
Author(s):  
Zhao Guiran ◽  
Wang Ying ◽  
Wang Guijun ◽  
Wang Chengyue ◽  
Yao Yusheng
Keyword(s):  
Bone Regeneration ◽  
Bone Morphogenetic Protein ◽  
Elastic Force ◽  
Human Bone ◽  
Bone Morphogenetic Protein 2 ◽  
Bone Morphogenetic Protein 4 ◽  
X Ray ◽  
Morphogenetic Protein ◽  
Human Bone Morphogenetic Protein ◽  
Recombinant Human Bone

Objective The purpose of this study was to evaluate the administration of recombinant human bone morphogenetic protein-2 (rhBMP-2) on trans-sutural distraction osteogenesis (TSDO) of the transverse palatal suture in growing dogs. Study Design A total of 36 growing dogs were used in this study. The experimental animals were treated with different elastic force and rhBMP-2. The bone regeneration was determined with X-ray, histology, and clinical evaluation. The computed values underwent statistical analyses using analysis of variance. Results The maxillary complex was most noticeably advanced with an applied elastic force of 600 g (22.4 ± 5.0 mm) and 800 g + rhBMP-2 (24 ± 5.1 mm). Immunohistochemical staining showed that the expression of bone morphogenetic protein-2 and bone morphogenetic protein-4 varied with different elastic force. These changes were statistically significant when 600 g and 800 g + rhBMP-2 were applied within 2 weeks of distraction when compared with controls ( P < .05). Conclusions The results of this study suggest that TSDO in the growing dog should be safe and well tolerated when inducing bony lengthening of the maxilla. rhBMP-2 plays an important role in bone regeneration using TSDO.

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