scholarly journals Chronic nicotine exposure systemically alters microRNA expression profiles during post-embryonic stages inCaenorhabditis elegans

2013 ◽  
pp. n/a-n/a ◽  
Author(s):  
Faten A Taki ◽  
Xiaoping Pan ◽  
Baohong Zhang
Keyword(s):  
Expression Profiles ◽  
Microrna Expression ◽  
Nicotine Exposure ◽  
Chronic Nicotine

scholarly journals Systematic Review of Nicotine Exposure’s Effects on Neural Stem and Progenitor Cells

2021 ◽  
Vol 11 (2) ◽  
pp. 172
Author(s):  
Arrin C. Brooks ◽  
Brandon J. Henderson
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Inverse Correlation ◽  
Hippocampal Neurogenesis ◽  
Nicotine Exposure ◽  
Negative Consequences ◽  
Postnatal Neurogenesis ◽  
Cognitive Behaviors ◽  
Chronic Nicotine ◽  
Stem And Progenitor Cells

While various modalities of chronic nicotine use have been associated with numerous negative consequences to human health, one possible benefit of nicotine exposure has been uncovered. The discovery of an inverse correlation between smoking and Parkinson’s disease, and later Alzheimer’s disease as well, motivated investigation of nicotine as a neuroprotective agent. Some studies have demonstrated that nicotine elicits improvements in cognitive function. The hippocampus, along with the subventricular zone (SVZ), is a distinct brain region that allow for ongoing postnatal neurogenesis throughout adulthood and plays a major role in certain cognitive behaviors like learning and memory. Therefore, one hypothesis underlying nicotine-induced neuroprotection is possible effects on neural stem cells and neural precursor cells. On the other hand, nicotine withdrawal frequently leads to cognitive impairments, particularly in hippocampal-dependent behaviors, possibly suggesting an impairment of hippocampal neurogenesis with nicotine exposure. This review discusses the current body of evidence on nicotine’s effects on neural stem cells and neural progenitors. Changes in neural stem cell proliferation, survival, intracellular dynamics, and differentiation following acute and chronic nicotine exposure are examined.

scholarly journals Identification of Tumorigenic and Prognostic Biomarkers in Colorectal Cancer Based on microRNA Expression Profiles

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Yuntao Shi ◽  
Yingying Zhuang ◽  
Jialing Zhang ◽  
Mengxue Chen ◽  
Shangnong Wu
Keyword(s):  
Target Genes ◽  
Cox Regression ◽  
Expression Profiles ◽  
Survival Rates ◽  
Enrichment Analysis ◽  
Functional Enrichment Analysis ◽  
Risk Groups ◽  
Normal Mucosa ◽  
Microrna Expression ◽  
Functional Enrichment

Objective. Although noncoding RNAs, especially the microRNAs, have been found to play key roles in CRC development in intestinal tissue, the specific mechanism of these microRNAs has not been fully understood. Methods. GEO and TCGA database were used to explore the microRNA expression profiles of normal mucosa, adenoma, and carcinoma. And the differential expression genes were selected. Computationally, we built the SVM model and multivariable Cox regression model to evaluate the performance of tumorigenic microRNAs in discriminating the adenomas from normal tissues and risk prediction. Results. In this study, we identified 20 miRNA biomarkers dysregulated in the colon adenomas. The functional enrichment analysis showed that MAPK activity and MAPK cascade were highly enriched by these tumorigenic microRNAs. We also investigated the target genes of the tumorigenic microRNAs. Eleven genes, including PIGF, TPI1, KLF4, RARS, PCBP2, EIF5A, HK2, RAVER2, HMGN1, MAPK6, and NDUFA2, were identified to be frequently targeted by the tumorigenic microRNAs. The high AUC value and distinct overall survival rates between the two risk groups suggested that these tumorigenic microRNAs had the potential of diagnostic and prognostic value in CRC. Conclusions. The present study revealed possible mechanisms and pathways that may contribute to tumorigenesis of CRC, which could not only be used as CRC early detection biomarkers, but also be useful for tumorigenesis mechanism studies.

scholarly journals MicroRNA expression profiles differentiate chronic pain condition subtypes

2015 ◽  
Vol 166 (6) ◽  
pp. 706-720.e11 ◽  
Author(s):  
Brittney P. Ciszek ◽  
Asma A. Khan ◽  
Hong Dang ◽  
Gary D. Slade ◽  
Shad Smith ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Expression Profiles ◽  
Microrna Expression ◽  
Chronic Pain Condition ◽  
Pain Condition

scholarly journals MicroRNA expression profiles of cancer stem cells in head and neck squamous cell carcinoma

2015 ◽  
Vol 47 (4) ◽  
pp. 1249-1256 ◽  
Author(s):  
KAZUYA YATA ◽  
LEVENT BEKIR BEDER ◽  
SHUNJI TAMAGAWA ◽  
MUNEKI HOTOMI ◽  
YOSHIHIKO HIROHASHI ◽  
...  
Keyword(s):  
Stem Cells ◽  
Squamous Cell Carcinoma ◽  
Cancer Stem Cells ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Expression Profiles ◽  
Microrna Expression ◽  
Neck Squamous Cell Carcinoma

scholarly journals Chronic Nicotine Exposure Abolishes Maternal Systemic and Renal Adaptations to Pregnancy in Rats

PLoS ONE ◽  
2016 ◽  
Vol 11 (2) ◽  
pp. e0150096 ◽  
Author(s):  
Vanessa Meira Ferreira ◽  
Clevia Santos Passos ◽  
Edgar Maquigussa ◽  
Roberto Braz Pontes ◽  
Cassia Toledo Bergamaschi ◽  
...  
Keyword(s):  
Nicotine Exposure ◽  
Chronic Nicotine

scholarly journals Sex differences in anxiety-like behavior and locomotor activity following chronic nicotine exposure in mice

2008 ◽  
Vol 439 (2) ◽  
pp. 187-191 ◽  
Author(s):  
Barbara J. Caldarone ◽  
Sarah L. King ◽  
Marina R. Picciotto
Keyword(s):  
Sex Differences ◽  
Locomotor Activity ◽  
Nicotine Exposure ◽  
Chronic Nicotine
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