scholarly journals Functional role of an islet transcription factor, INSM1/IA-1, on pancreatic acinar cell trans-differentiation

2012 ◽  
Vol 227 (6) ◽  
pp. 2470-2479 ◽  
Author(s):  
Tao Zhang ◽  
Nicolle A. Saunee ◽  
Mary B. Breslin ◽  
Kejing Song ◽  
Michael S. Lan
Keyword(s):  
Transcription Factor ◽  
Acinar Cell ◽  
Functional Role ◽  
Pancreatic Acinar Cell

Role of sulfated O-linked glycoproteins in zymogen granule formation

2002 ◽  
Vol 115 (14) ◽  
pp. 2941-2952 ◽  
Author(s):  
Robert C. De Lisle
Keyword(s):  
Acinar Cell ◽  
Secretory Granules ◽  
Sodium Chlorate ◽  
Pancreatic Acinar Cell ◽  
Secretory Proteins ◽  
Zymogen Granule ◽  
Acidic Ph ◽  
Zymogen Granules ◽  
Granule Formation

Packaging of proteins into regulated secretory granules is mediated by the mildly acidic pH of the trans Golgi network and immature secretory granules. This need for an acidic pH indicates that ionic interactions are important. The mouse pancreatic acinar cell contains four major sulfated glycoproteins,including the zymogen granule structural component Muclin. I tested the hypothesis that sulfation and the O-linked glycosylation to which the sulfates are attached are required for normal formation of zymogen granules in the exocrine pancreas. Post-translational processing was perturbed with two chemicals: sodium chlorate was used to inhibit sulfation and benzyl-N-acetyl-α-galactosaminide was used to inhibit O-linked oligosaccharide elongation. Both chemicals resulted in the accumulation in the Golgi region of the cell of large vacuoles that appear to be immature secretory granules, and the effect was much more extensive with benzyl-N-acetyl-α-galactosaminide than chlorate. Both chemical treatments inhibited basal secretion at prolonged chase times, and again benzyl-N-acetyl-α-galactosaminide had a greater effect than chlorate. In addition, benzyl-N-acetyl-α-galactosaminide, but not chlorate, totally inhibited stimulated secretion of newly synthesized proteins. These data provide evidence for a role of sulfated O-linked glycoproteins in protein condensation and maturation of zymogen granules. Under maximal inhibition of O-linked oligosaccharide biosynthesis, anterograde post-Golgi traffic in the regulated pathway is almost totally shut down, demonstrating the importance of these post-translational modifications in progression of secretory proteins through the regulated pathway and normal granule formation in the pancreatic acinar cell.

Defining the role of systemic therapy in resectable pancreatic acinar cell carcinoma

2022 ◽  
Author(s):  
Paul R. Burchard ◽  
Alexander C. Chacon ◽  
Alexa Melucci ◽  
Anthony S. Casabianca ◽  
Subir Goyal ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Acinar Cell ◽  
Systemic Therapy ◽  
Acinar Cell Carcinoma ◽  
Pancreatic Acinar Cell ◽  
Pancreatic Acinar Cell Carcinoma

Sa1860 SRC-Dependent Role of CCK in the Pancreatic Acinar Cell Signaling and Chemokine Release

2013 ◽  
Vol 144 (5) ◽  
pp. S-322
Author(s):  
Bernardo Nuche-Berenguer ◽  
Taichi Nakamura ◽  
Paola Moreno ◽  
Robert T. Jensen
Keyword(s):  
Cell Signaling ◽  
Acinar Cell ◽  
Pancreatic Acinar Cell

Extracellular matrix modulates insulin production during differentiation of AR42J cells: Functional role of Pax6 transcription factor

2011 ◽  
Vol 112 (1) ◽  
pp. 318-329 ◽  
Author(s):  
Kohei Hamamoto ◽  
Satoko Yamada ◽  
Akemi Hara ◽  
Tsutomu Kodera ◽  
Masaharu Seno ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Transcription Factor ◽  
Functional Role ◽  
Insulin Production ◽  
Ar42j Cells

The role of receptor interacting protein kinase 1 (RIPK1) in bile acid-induced pancreatic acinar cell death

Pancreatology ◽  
2015 ◽  
Vol 15 (3) ◽  
pp. S8
Author(s):  
Yulin Ouyang ◽  
S. Voronina ◽  
M. Chvanov ◽  
L. Wen ◽  
D. Latawiec ◽  
...  
Keyword(s):  
Cell Death ◽  
Bile Acid ◽  
Protein Kinase ◽  
Acinar Cell ◽  
Pancreatic Acinar Cell ◽  
Interacting Protein
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