scholarly journals Mitochondrial DNA mutations in respiratory complex-I in never-smoker lung cancer patients contribute to lung cancer progression and associated withEGFRgene mutation

2012 ◽  
Vol 227 (6) ◽  
pp. 2451-2460 ◽  
Author(s):  
Santanu Dasgupta ◽  
Ethan Soudry ◽  
Nitai Mukhopadhyay ◽  
Chunbo Shao ◽  
John Yee ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Mitochondrial Dna ◽  
Cancer Patients ◽  
Cancer Progression ◽  
Complex I ◽  
Lung Cancer Patients ◽  
Mitochondrial Dna Mutations ◽  
Dna Mutations ◽  
Respiratory Complex I ◽  
Never Smoker

scholarly journals Mitochondrial DNA mutations in exhaled breath condensate of patients with lung cancer

2013 ◽  
Vol 107 (6) ◽  
pp. 911-918 ◽  
Author(s):  
Sylvia Si Yang Ai ◽  
Kenneth Hsu ◽  
Cristan Herbert ◽  
Zujian Cheng ◽  
John Hunt ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Mitochondrial Dna ◽  
Exhaled Breath Condensate ◽  
Exhaled Breath ◽  
Mitochondrial Dna Mutations ◽  
Dna Mutations ◽  
Breath Condensate

P59 Respiratory chain complex I deficiency caused by mitochondrial DNA mutations

2011 ◽  
Vol 21 ◽  
pp. S23
Author(s):  
R.W. Taylor ◽  
H. Swalwell ◽  
D.M. Kirby ◽  
E.L. Blakely ◽  
A. Mitchell ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Respiratory Chain ◽  
Complex I ◽  
Chain Complex ◽  
Respiratory Chain Complex ◽  
Mitochondrial Dna Mutations ◽  
Dna Mutations ◽  
Complex I Deficiency

scholarly journals High Level of Staufen1 Expression Confers Longer Recurrence Free Survival to Non-Small Cell Lung Cancer Patients by Promoting THBS1 mRNA Degradation

2021 ◽  
Vol 23 (1) ◽  
pp. 215
Author(s):  
Florence Bonnet-Magnaval ◽  
Leïla Halidou Diallo ◽  
Valérie Brunchault ◽  
Nathalie Laugero ◽  
Florent Morfoisse ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Adhesion ◽  
Cancer Patients ◽  
Cancer Progression ◽  
Rna Binding ◽  
Recurrence Free Survival ◽  
Free Survival ◽  
Lung Cancer Patients

Stau1 is a pluripotent RNA-binding protein that is responsible for the post-transcriptional regulation of a multitude of transcripts. Here, we observed that lung cancer patients with a high Stau1 expression have a longer recurrence free survival. Strikingly, Stau1 did not impair cell proliferation in vitro, but rather cell migration and cell adhesion. In vivo, Stau1 depletion favored tumor progression and metastases development. In addition, Stau1 depletion strongly impaired vessel maturation. Among a panel of candidate genes, we specifically identified the mRNA encoding the cell adhesion molecule Thrombospondin 1 (THBS1) as a new target for Staufen-mediated mRNA decay. Altogether, our results suggest that regulation of THBS1 expression by Stau1 may be a key process involved in lung cancer progression.

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