NADPH oxidase 4 mediates upregulation of type 4 phosphodiesterases in human endothelial cells

2012 ◽  
Vol 227 (5) ◽  
pp. 1941-1950 ◽  
Author(s):  
Saima Muzaffar ◽  
Jamie Y. Jeremy ◽  
Gianni D. Angelini ◽  
Nilima Shukla
Keyword(s):  
Endothelial Cells ◽  
Nadph Oxidase ◽  
Human Endothelial Cells ◽  
Nadph Oxidase 4

Mitochondrial respiratory chain complex I is inactivated by NADPH oxidase Nox4

2013 ◽  
Vol 452 (2) ◽  
pp. 231-239 ◽  
Author(s):  
Rafał Kozieł ◽  
Haymo Pircher ◽  
Manuela Kratochwil ◽  
Barbara Lener ◽  
Martin Hermann ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Nadph Oxidase ◽  
Complex I ◽  
Chain Complex ◽  
Mitochondrial Morphology ◽  
Human Endothelial Cells ◽  
Native Page ◽  
Mitochondrial Respiratory Chain Complex ◽  
Permeabilized Cells ◽  
Nadph Oxidase 4

ROS (reactive oxygen species) generated by NADPH oxidases play an important role in cellular signal transduction regulating cell proliferation, survival and differentiation. Nox4 (NADPH oxidase 4) induces cellular senescence in human endothelial cells; however, intracellular targets for Nox4 remained elusive. In the present study, we show that Nox4 induces mitochondrial dysfunction in human endothelial cells. Nox4 depletion induced alterations in mitochondrial morphology, stabilized mitochondrial membrane potential and decreased production of H2O2 in mitochondria. High-resolution respirometry in permeabilized cells combined with native PAGE demonstrated that Nox4 specifically inhibits the activity of mitochondrial electron transport chain complex I, and this was associated with a decreased concentration of complex I subunits. These data suggest a new pathway by which sustained Nox4 activity decreases mitochondrial function.

963 Prostacyclin regulates NADPH oxidase 4 in human endothelial CELLS THEREBY promoting Cytoprotection

2012 ◽  
Vol 30 ◽  
pp. e278
Author(s):  
Hitesh M. Peshavariya ◽  
Guei-Sheung Liu ◽  
Catherine W.T. Chang ◽  
Fan Jiang ◽  
Elsa C. Chan ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Nadph Oxidase ◽  
Human Endothelial Cells ◽  
Nadph Oxidase 4

scholarly journals Annexin Peptide Ac2-26 Suppresses TNFα-Induced Inflammatory Responses via Inhibition of Rac1-Dependent NADPH Oxidase in Human Endothelial Cells

PLoS ONE ◽  
2013 ◽  
Vol 8 (4) ◽  
pp. e60790 ◽  
Author(s):  
Hitesh M. Peshavariya ◽  
Caroline J. Taylor ◽  
Celeste Goh ◽  
Guei-Sheung Liu ◽  
Fan Jiang ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Nadph Oxidase ◽  
Inflammatory Responses ◽  
Human Endothelial Cells

scholarly journals NO Modulates NADPH Oxidase Function Via Heme Oxygenase-1 in Human Endothelial Cells

Hypertension ◽  
2006 ◽  
Vol 48 (5) ◽  
pp. 950-957 ◽  
Author(s):  
Fan Jiang ◽  
Sarah J. Roberts ◽  
Srinivasa raju Datla ◽  
Gregory J. Dusting
Keyword(s):  
Endothelial Cells ◽  
Nadph Oxidase ◽  
Heme Oxygenase ◽  
Heme Oxygenase 1 ◽  
Human Endothelial Cells

Biphasic regulation of NADPH oxidase expression by protein kinase C in human endothelial cells

2006 ◽  
Vol 2006 (Spring) ◽  
Author(s):  
Huige Li ◽  
Hui Xu ◽  
Isolde Brausch ◽  
Marcus Hortmann ◽  
Ulrich Förstermann
Keyword(s):  
Endothelial Cells ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Nadph Oxidase ◽  
Human Endothelial Cells ◽  
Kinase C

Nitric oxide mediates NADPH oxidase function via heme oxygenase-1 in human endothelial cells

2006 ◽  
Vol 45 (3) ◽  
pp. e78
Author(s):  
Fan Jiang ◽  
Sarah J. Roberts ◽  
Srinivasa Raju Datla ◽  
Gregory J. Dusting
Keyword(s):  
Nitric Oxide ◽  
Endothelial Cells ◽  
Nadph Oxidase ◽  
Heme Oxygenase ◽  
Heme Oxygenase 1 ◽  
Human Endothelial Cells

APE1/Ref-1 promotes the effect of Angiotensin II on Ca2+-activated K+ channel in human endothelial cells via suppression of NADPH Oxidase

2008 ◽  
Vol 31 (10) ◽  
pp. 1291-1301 ◽  
Author(s):  
Won Sun Park ◽  
Eun A. Ko ◽  
In Duk Jung ◽  
Youn Kyoung Son ◽  
Hyoung Kyu Kim ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Angiotensin Ii ◽  
Nadph Oxidase ◽  
K Channel ◽  
Human Endothelial Cells
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