scholarly journals Diabetic retinopathy and signaling mechanism for activation of matrix metalloproteinase-9

2011 ◽  
Vol 227 (3) ◽  
pp. 1052-1061 ◽  
Author(s):  
Ghulam Mohammad ◽  
Renu A. Kowluru
Keyword(s):  
Diabetic Retinopathy ◽  
Matrix Metalloproteinase ◽  
Matrix Metalloproteinase 9 ◽  
Signaling Mechanism ◽  
Metalloproteinase 9

scholarly journals Role of matrix metalloproteinase 9 and its tissue inhibitor 1 in development and prognosis of diabetic retinopathy

2016 ◽  
Vol 62 (5) ◽  
pp. 37-44 ◽  
Author(s):  
S.V. Ziablitsev ◽  
◽  
A.V. Korobova ◽  
O.V. Petrenko ◽  
V.N. Serduk ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Matrix Metalloproteinase ◽  
Matrix Metalloproteinase 9 ◽  
Tissue Inhibitor ◽  
Metalloproteinase 9

scholarly journals Mycobacterial Lipomannan Induces Matrix Metalloproteinase-9 Expression in Human Macrophagic Cells through a Toll-Like Receptor 1 (TLR1)/TLR2- and CD14-Dependent Mechanism

2005 ◽  
Vol 73 (10) ◽  
pp. 7064-7068 ◽  
Author(s):  
Elisabeth Elass ◽  
Laëtitia Aubry ◽  
Maryse Masson ◽  
Agnès Denys ◽  
Yann Guérardel ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Neutralizing Antibodies ◽  
Matrix Metalloproteinase 9 ◽  
Human Macrophage ◽  
Toll Like Receptor ◽  
Signaling Mechanism ◽  
The Matrix ◽  
Inhibition Studies ◽  
Metalloproteinase 9 ◽  
Dependent Mechanism

ABSTRACT Lipomannans (LM) from various mycobacterial species were found to induce expression and secretion of the matrix metalloproteinase 9 (MMP-9) both in human macrophage-like differentiated THP-1 cells and in primary human macrophages. Inhibition studies using antireceptor-neutralizing antibodies are indicative of a Toll-like receptor 1 (TLR1)/TLR2- and CD14-dependent signaling mechanism. Moreover, LM was shown to down-regulate transcription of the metalloproteinase inhibitor TIMP-1, a major endogenous MMP-9 regulator.

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