scholarly journals t10c12-CLA maintains higher bone mineral density during aging by modulating osteoclastogenesis and bone marrow adiposity

2011 ◽  
Vol 226 (9) ◽  
pp. 2406-2414 ◽  
Author(s):  
Md M. Rahman ◽  
Ganesh V. Halade ◽  
Paul J. Williams ◽  
Gabriel Fernandes
Keyword(s):  
Bone Mineral Density ◽  
Bone Marrow ◽  
Bone Mineral ◽  
Mineral Density ◽  
Marrow Adiposity

scholarly journals Nox2 Activity Is Required in Obesity-Mediated Alteration of Bone Remodeling

2018 ◽  
Vol 2018 ◽  
pp. 1-10
Author(s):  
Md Mizanur Rahman ◽  
Amina El Jamali ◽  
Ganesh V. Halade ◽  
Allal Ouhtit ◽  
Haissam Abou-Saleh ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Marrow ◽  
Bone Remodeling ◽  
Bone Mineral ◽  
Bone Marrow Cells ◽  
Bone Marrow Microenvironment ◽  
Ros Generation ◽  
Chow Diet ◽  
Mineral Density ◽  
Marrow Cells

Despite increasing evidence suggesting a role for NADPH oxidases (Nox) in bone pathophysiology, whether Nox enzymes contribute to obesity-mediated bone remodeling remains to be clearly elucidated. Nox2 is one of the predominant Nox enzymes expressed in the bone marrow microenvironment and is a major source of ROS generation during inflammatory processes. It is also well recognized that a high-fat diet (HFD) induces obesity, which negatively impacts bone remodeling. In this work, we investigated the effect of Nox2 loss of function on obesity-mediated alteration of bone remodeling using wild-type (WT) and Nox2-knockout (KO) mice fed with a standard lab chow diet (SD) as a control or a HFD as an obesity model. Bone mineral density (BMD) of mice was assessed at the beginning and after 3 months of feeding with SD or HFD. Our results show that HFD increased bone mineral density to a greater extent in KO mice than in WT mice without affecting the total body weight and fat mass. HFD also significantly increased the number of adipocytes in the bone marrow microenvironment of WT mice as compared to KO mice. The bone levels of proinflammatory cytokines and proosteoclastogenic factors were also significantly elevated in WT-HFD mice as compared to KO-HFD mice. Furthermore, the in vitro differentiation of bone marrow cells into osteoclasts was significantly increased when using bone marrow cells from WT-HFD mice as compared to KO-HFD mice. Our data collectively suggest that Nox2 is implicated in HFD-induced deleterious bone remodeling by enhancing bone marrow adipogenesis and osteoclastogenesis.

scholarly journals 397 HIP BONE MINERAL DENSITY DOES NOT INFLUENCE TIBIOFEMORAL BONE MARROW LESION SIZE

2011 ◽  
Vol 19 ◽  
pp. S183-S184
Author(s):  
J.B. Driban ◽  
G.H. Lo ◽  
L.L. Price ◽  
T.E. McAlindon
Keyword(s):  
Bone Mineral Density ◽  
Bone Marrow ◽  
Bone Mineral ◽  
Lesion Size ◽  
Bone Marrow Lesion ◽  
Mineral Density

scholarly journals Picolinic acid, a tryptophan oxidation product, does not impact bone mineral density but increases marrow adiposity

2020 ◽  
Vol 133 ◽  
pp. 110885 ◽  
Author(s):  
Kehong Ding ◽  
Meghan E. McGee-Lawrence ◽  
Helen Kaiser ◽  
Anuj K. Sharma ◽  
Jessica L. Pierce ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Oxidation Product ◽  
Picolinic Acid ◽  
Mineral Density ◽  
Marrow Adiposity ◽  
Tryptophan Oxidation

A study of bone marrow and subcutaneous fatty acid composition in subjects of varying bone mineral density

Bone ◽  
2009 ◽  
Vol 44 (6) ◽  
pp. 1092-1096 ◽  
Author(s):  
James F. Griffith ◽  
David K.W. Yeung ◽  
Anil T. Ahuja ◽  
Carol W.Y. Choy ◽  
Wong Yin Mei ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Marrow ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Acid Composition ◽  
Bone Mineral ◽  
Mineral Density

scholarly journals Osteopenia in Sparc (osteonectin)-deficient mice: characterization of phenotypic determinants of femoral strength and changes in gene expression

2007 ◽  
Vol 32 (1) ◽  
pp. 64-73 ◽  
Author(s):  
Fiona C. Mansergh ◽  
Timothy Wells ◽  
Carole Elford ◽  
Samuel L. Evans ◽  
Mark J. Perry ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Mineral ◽  
Mouse Strains ◽  
Mineral Density ◽  
Background Strain ◽  
Marrow Adiposity ◽  
Strength Tests ◽  
Deficient Mice ◽  
Inactivating Mutations

Sparc null mutants have been generated independently via targeted mutations in exons 4 and 6. Previous studies have identified low-turnover osteopenia in the 129Sv/C57BL/6 exon 4 knockout. Since both Sparc null mutations result in complete absence of Sparc protein, similar phenotypic outcomes are likely. However, genetic background (strain) and/or linkage disequilibrium effects can influence phenotype. Different inactivating mutations should be tested in various mouse strains; similar phenotypic outcomes can then confidently be assigned to the mutated gene. We have evaluated the bone phenotype in the 129Sv/EvSparc tm1cam exon 6 knockout at 4 and 9 mo, using physical measurement, mechanical strength tests, and DXA scanning. We have also quantified bone marrow adiposity and circulating leptin levels to assess adipose tissue metabolism. 129Sv/EvSparc tm1cam null mice show decreased bone mineral density and bone mineral content and increased mechanical fragility of bone, in line with previous studies. Differences were also noted. Increased body weight and levels of bone marrow adiposity but decreased circulating leptin concentrations were identified at 4, but not 9 mo, and 129Sv/EvSparc tm1cam null mice also had shorter femurs. Molecular phenotyping was carried out using mouse HGMP NIA microarrays with cortical femur samples at various ages, using semiquantitative RT-PCR validation. We identified 429 genes highly expressed in normal bone. Six genes (Sparc, Zfp162, Bysl, E2F4, two ESTs) are differentially regulated in 129Sv/EvSparc tm1cam cortical femur vs. 129Sv/Ev controls. We confirm low-turnover osteopenia as a feature of the Sparc null phenotype, identifying the usefulness of this mouse as a model for human osteoporosis.

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