scholarly journals Knockdown of heme oxygenase-2 impairs corneal epithelial cell wound healing

2011 ◽  
Vol 226 (7) ◽  
pp. 1732-1740 ◽  
Author(s):  
Adna Halilovic ◽  
Kiran A. Patil ◽  
Lars Bellner ◽  
Giuseppina Marrazzo ◽  
Kirkland Castellano ◽  
...  
Keyword(s):  
Wound Healing ◽  
Epithelial Cell ◽  
Heme Oxygenase ◽  
Corneal Epithelial Cell ◽  
Corneal Epithelial

scholarly journals Potential role of corneal epithelial cell-derived exosomes in corneal wound healing and neovascularization

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Kyu-Yeon Han ◽  
Jennifer A. Tran ◽  
Jin-Hong Chang ◽  
Dimitri T. Azar ◽  
James D. Zieske
Keyword(s):  
Wound Healing ◽  
Epithelial Cell ◽  
Potential Role ◽  
Corneal Epithelial Cell ◽  
Corneal Wound Healing ◽  
Corneal Epithelial ◽  
Corneal Wound

scholarly journals The Yin and Yang of the Opioid Growth Regulatory System: Focus on Diabetes—The Lorenz E. Zimmerman Tribute Lecture

2016 ◽  
Vol 2016 ◽  
pp. 1-23 ◽  
Author(s):  
Joseph W. Sassani ◽  
Patricia J. Mc Laughlin ◽  
Ian S. Zagon
Keyword(s):  
Wound Healing ◽  
Cell Division ◽  
Epithelial Cell ◽  
Regulatory System ◽  
Corneal Epithelial Cell ◽  
Diabetes In Animals ◽  
Corneal Epithelial ◽  
Long Acting

The Opioid Growth Regulatory System consists of opioid growth factor (OGF), [Met5]-enkephalin, and its unique receptor (OGFr). OGF inhibits cell division when bound to OGFr. Conversely, blockade of the interaction of OGF and OGFr, using the potent, long-acting opioid receptor antagonist, naltrexone (NTX), results in increased DNA synthesis and cell division. The authors have demonstrated bothin vitroandin vivothat the addition of exogenous OGF or an increase in available OGFr decreases corneal epithelial cell division and wound healing. Conversely, blockade of the OGF-OGFr interaction by NTX or a decrease in the production of the OGFr increases corneal epithelial cell division and facilitates corneal epithelial wound healing. The authors also have demonstrated that depressed corneal and cutaneous wound healing, dry eye, and abnormal corneal sensitivity in type 1 and type 2 diabetes in animals can be reversed by OGF-OGFr blockade by NTX. Thus, the function of the Opioid Growth Regulatory System appears to be disordered in diabetic animals, and its function can be restored with NTX treatment. These studies suggest a fundamental role for the Opioid Growth Regulatory System in the pathobiology of diabetic complications and a need for studies to elucidate this role further.

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