Artefactual effects of oxygen on cell culture models of cellular senescence and stem cell biology

2010 ◽  
Vol 226 (2) ◽  
pp. 315-321 ◽  
Author(s):  
Olivier Toussaint ◽  
Geoffroy Weemaels ◽  
Florence Debacq-Chainiaux ◽  
Karin Scharffetter-Kochanek ◽  
Meinhard Wlaschek
Keyword(s):  
Cell Culture ◽  
Stem Cell ◽  
Cellular Senescence ◽  
Cell Biology ◽  
Stem Cell Biology ◽  
Culture Models ◽  
Cell Culture Models

scholarly journals Three-Dimensional Human Alveolar Stem Cell Culture Models Reveal Infection Response to SARS-CoV-2

2020 ◽  
Vol 27 (6) ◽  
pp. 905-919.e10 ◽  
Author(s):  
Jeonghwan Youk ◽  
Taewoo Kim ◽  
Kelly V. Evans ◽  
Young-Il Jeong ◽  
Yongsuk Hur ◽  
...  
Keyword(s):  
Cell Culture ◽  
Stem Cell ◽  
Three Dimensional ◽  
Stem Cell Culture ◽  
Culture Models ◽  
Infection Response ◽  
Cell Culture Models

scholarly journals Implications of Cellular Senescence in Tissue Damage Response, Tumor Suppression, and Stem Cell Biology

2008 ◽  
Vol 73 (0) ◽  
pp. 513-522 ◽  
Author(s):  
V. Krizhanovsky ◽  
W. Xue ◽  
L. Zender ◽  
M. Yon ◽  
E. Hernando ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cellular Senescence ◽  
Tissue Damage ◽  
Tumor Suppression ◽  
Cell Biology ◽  
Stem Cell Biology ◽  
Damage Response

scholarly journals Pediatric and Adult High-Grade Glioma Stem Cell Culture Models Are Permissive to Lytic Infection with Parvovirus H-1

Viruses ◽  
2016 ◽  
Vol 8 (5) ◽  
pp. 138 ◽  
Author(s):  
Rafael Josupeit ◽  
Sebastian Bender ◽  
Sonja Kern ◽  
Barbara Leuchs ◽  
Thomas Hielscher ◽  
...  
Keyword(s):  
Cell Culture ◽  
Stem Cell ◽  
High Grade Glioma ◽  
Lytic Infection ◽  
High Grade ◽  
Glioma Stem Cell ◽  
Stem Cell Culture ◽  
Culture Models ◽  
Cell Culture Models

scholarly journals Physical Exercise and Cardiac Repair: The Potential Role of Nitric Oxide in Boosting Stem Cell Regenerative Biology

Antioxidants ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1002
Author(s):  
Fabiola Marino ◽  
Mariangela Scalise ◽  
Eleonora Cianflone ◽  
Luca Salerno ◽  
Donato Cappetta ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Stem Cell ◽  
Physical Exercise ◽  
Cell Biology ◽  
Molecular Mechanisms ◽  
Heart Function ◽  
Stem Cell Biology ◽  
Myocardial Repair ◽  
Beneficial Effects

Over the years strong evidence has been accumulated showing that aerobic physical exercise exerts beneficial effects on the prevention and reduction of cardiovascular risk. Exercise in healthy subjects fosters physiological remodeling of the adult heart. Concurrently, physical training can significantly slow-down or even reverse the maladaptive pathologic cardiac remodeling in cardiac diseases, improving heart function. The underlying cellular and molecular mechanisms of the beneficial effects of physical exercise on the heart are still a subject of intensive study. Aerobic activity increases cardiovascular nitric oxide (NO) released mainly through nitric oxidase synthase 3 activity, promoting endothelium-dependent vasodilation, reducing vascular resistance, and lowering blood pressure. On the reverse, an imbalance between increasing free radical production and decreased NO generation characterizes pathologic remodeling, which has been termed the “nitroso-redox imbalance”. Besides these classical evidence on the role of NO in cardiac physiology and pathology, accumulating data show that NO regulate different aspects of stem cell biology, including survival, proliferation, migration, differentiation, and secretion of pro-regenerative factors. Concurrently, it has been shown that physical exercise generates physiological remodeling while antagonizes pathologic remodeling also by fostering cardiac regeneration, including new cardiomyocyte formation. This review is therefore focused on the possible link between physical exercise, NO, and stem cell biology in the cardiac regenerative/reparative response to physiological or pathological load. Cellular and molecular mechanisms that generate an exercise-induced cardioprotective phenotype are discussed in regards with myocardial repair and regeneration. Aerobic training can benefit cells implicated in cardiovascular homeostasis and response to damage by NO-mediated pathways that protect stem cells in the hostile environment, enhance their activation and differentiation and, in turn, translate to more efficient myocardial tissue regeneration. Moreover, stem cell preconditioning by and/or local potentiation of NO signaling can be envisioned as promising approaches to improve the post-transplantation stem cell survival and the efficacy of cardiac stem cell therapy.

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