scholarly journals Tumor suppressors Sav/scrib and oncogene ras regulate stem-cell transformation in adult Drosophila malpighian tubules

2010 ◽  
Vol 224 (3) ◽  
pp. 766-774 ◽  
Author(s):  
Xiankun Zeng ◽  
Shree Ram Singh ◽  
David Hou ◽  
Steven X. Hou
Keyword(s):  
Stem Cell ◽  
Tumor Suppressors ◽  
Cell Transformation ◽  
Malpighian Tubules ◽  
Adult Drosophila

scholarly journals Regulation of sarcomagenesis by the empty spiracles homeobox genes EMX1 and EMX2

2021 ◽  
Vol 12 (6) ◽  
Author(s):  
Manuel Pedro Jimenez-García ◽  
Antonio Lucena-Cacace ◽  
Daniel Otero-Albiol ◽  
Amancio Carnero
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Transcription Factors ◽  
Neural Crest ◽  
Tumor Suppressors ◽  
Homeobox Genes ◽  
Neuronal Cell ◽  
Cell Gene Expression

AbstractThe EMX (Empty Spiracles Homeobox) genes EMX1 and EMX2 are two homeodomain gene members of the EMX family of transcription factors involved in the regulation of various biological processes, such as cell proliferation, migration, and differentiation, during brain development and neural crest migration. They play a role in the specification of positional identity, the proliferation of neural stem cells, and the differentiation of certain neuronal cell phenotypes. In general, they act as transcription factors in early embryogenesis and neuroembryogenesis from metazoans to higher vertebrates. The EMX1 and EMX2’s potential as tumor suppressor genes has been suggested in some cancers. Our work showed that EMX1/EMX2 act as tumor suppressors in sarcomas by repressing the activity of stem cell regulatory genes (OCT4, SOX2, KLF4, MYC, NANOG, NES, and PROM1). EMX protein downregulation, therefore, induced the malignance and stemness of cells both in vitro and in vivo. In murine knockout (KO) models lacking Emx genes, 3MC-induced sarcomas were more aggressive and infiltrative, had a greater capacity for tumor self-renewal, and had higher stem cell gene expression and nestin expression than those in wild-type models. These results showing that EMX genes acted as stemness regulators were reproduced in different subtypes of sarcoma. Therefore, it is possible that the EMX genes could have a generalized behavior regulating proliferation of neural crest-derived progenitors. Together, these results indicate that the EMX1 and EMX2 genes negatively regulate these tumor-altering populations or cancer stem cells, acting as tumor suppressors in sarcoma.

scholarly journals A Metabolic Bottleneck for Stem Cell Transformation

Cell ◽  
2020 ◽  
Vol 182 (6) ◽  
pp. 1377-1378
Author(s):  
Sanjeethan C. Baksh ◽  
Elaine Fuchs
Keyword(s):  
Stem Cell ◽  
Cell Transformation

Memoirs: Peristalsis in the Malpighian Tubules of Diptera, Preliminary Account: with a note on the Elimination of Calcium Carbonate from the Malpighian Tubules of Drosophila Funebris

1925 ◽  
Vol s2-69 (275) ◽  
pp. 385-398
Author(s):  
L. EASTHAM
Keyword(s):  
Calcium Carbonate ◽  
Basement Membrane ◽  
Longitudinal Muscle ◽  
The Body ◽  
Malpighian Tubules ◽  
Preliminary Account ◽  
Longitudinal Muscles ◽  
Adult Drosophila

1. The proximal regions of the Malpighian tubules of Drosopbila funebris and Calliphora erythro cephala are supplied with systems of circular and longitudinal muscles external to the basement membrane. 2. These muscles are continuous with those of the mid-gut. 3. There is a terminal muscle to each anterior tubule in Drosophila funebris connected to the alar muscles of the pericardial septum. 4. Peristalsis has been observed in the proximal regions of the tubules, caused by the circular muscles. 5. The tubules exhibit a waving movement, probably due to the longitudinal muscle-bands of the lower or proximal ends of the tubules. 6. Calcium carbonate is stored in the terminal portions of the anterior tubules of Drosophila funebris. 7. This calcium carbonate is not eliminated at the beginning of metamorphosis, but is passed to the gut about the sixth day of pupal life, and is only expelled from the body on the emergence of the adult. 8. Calcium carbonate is found in the Malpighian tubules of the adult Drosophila funebris.

scholarly journals Spontaneous Human Adult Stem Cell Transformation

2005 ◽  
Vol 65 (8) ◽  
pp. 3035-3039 ◽  
Author(s):  
Daniel Rubio ◽  
Javier Garcia-Castro ◽  
María C. Martín ◽  
Ricardo de la Fuente ◽  
Juan C. Cigudosa ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Transformation ◽  
Adult Stem Cell ◽  
Human Adult

Abstract 3393: Extrinsic uPA initiates glioma stem cell transformation under hypoxic conditions via Lhx-2

2011 ◽  
Author(s):  
Christopher S. Gondi ◽  
Bharathi Gorantla ◽  
Swapna Asuthkar ◽  
Jasti S. Rao
Keyword(s):  
Stem Cell ◽  
Cell Transformation ◽  
Glioma Stem Cell ◽  
Hypoxic Conditions

scholarly journals Damage sensing by a Nox-Ask1-MKK3-p38 signaling pathway mediates regeneration in the adult Drosophila midgut

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Parthive H. Patel ◽  
Clothilde Pénalva ◽  
Michael Kardorff ◽  
Marianne Roca ◽  
Bojana Pavlović ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Stem Cell ◽  
Nadph Oxidase ◽  
Bacterial Infection ◽  
Intestinal Stem Cell ◽  
Oxygen Species ◽  
Damage Sensing ◽  
Mechanical Insult ◽  
Adult Drosophila

Abstract Epithelia are exposed to diverse types of stress and damage from pathogens and the environment, and respond by regenerating. Yet, the proximal mechanisms that sense epithelial damage remain poorly understood. Here we report that p38 signaling is activated in adult Drosophila midgut enterocytes in response to diverse stresses including pathogenic bacterial infection and chemical and mechanical insult. Two upstream kinases, Ask1 and Licorne (MKK3), are required for p38 activation following infection, oxidative stress, detergent exposure and wounding. Ask1-p38 signaling in enterocytes is required upon infection to promote full intestinal stem cell (ISC) activation and regeneration, partly through Upd3/Jak-Stat signaling. Furthermore, reactive oxygen species (ROS) produced by the NADPH oxidase Nox in enterocytes, are required for p38 activation in enterocytes following infection or wounding, and for ISC activation upon infection or detergent exposure. We propose that Nox-ROS-Ask1-MKK3-p38 signaling in enterocytes integrates multiple different stresses to induce regeneration.

Propranolol Accelerats Hemangioma Stem Cell Transformation Into Adipocyte

2019 ◽  
Vol 83 (5) ◽  
pp. e5-e13 ◽  
Author(s):  
Hong-hong Li ◽  
Yin Lou ◽  
Rong-rong Zhang ◽  
Juan Xie ◽  
Dong-sheng Cao
Keyword(s):  
Stem Cell ◽  
Cell Transformation
Sign in / Sign up

Export Citation Format

Share Document