Osteoblastic bone formation is induced by using nanogel-crosslinking hydrogel as novel scaffold for bone growth factor

2009 ◽  
Vol 220 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Chikako Hayashi ◽  
Urara Hasegawa ◽  
Yoshitomo Saita ◽  
Hiroaki Hemmi ◽  
Tadayoshi Hayata ◽  
...  
Keyword(s):  
Growth Factor ◽  
Bone Formation ◽  
Bone Growth ◽  
Osteoblastic Bone Formation ◽  
Bone Growth Factor ◽  
Novel Scaffold

Functionalized Calcium Phosphate-based Nanoparticles for the Treatment of Osteoporosis

2005 ◽  
Vol 873 ◽  
Author(s):  
Balasundaram G ◽  
Sato M ◽  
Webster TJ
Keyword(s):  
Calcium Phosphate ◽  
Bone Formation ◽  
Amorphous Calcium Phosphate ◽  
Bone Growth ◽  
Osteoporotic Bone ◽  
Amino Groups ◽  
Calcium Phosphate Nanoparticles ◽  
Bioactive Agents ◽  
Bone Growth Factor

AbstractIn an effort to decrease the number of problems associated with osteoporosis, the long-term goal of the present study is to design calcium phosphate-based nanoparticles that specifically attach to areas of low bone density and once attached, allow for the targeted release of bioactive agents that can quickly increase bone formation. Efforts are focused on nanoparticles of calcium phosphate-based materials since they are similar in size and chemistry to the major inorganic components of bone. As a first step in this research, the objective of the present study was to synthesize nanoparticles of crystalline hydroxyapatite (or HA) and amorphous calcium phosphate. Crystalline HA is stable under physiological fluids and, thus, will release embedded bioactive agents slowly. Alternatively, amorphous calcium phosphate is highly biodegradable and will, thus, release embedded bioactive agents quickly. A further objective of the present study was to functionalize such inorganic biodegradable materials with amino groups which would allow for the subsequent attachment of entities to direct such nanoparticles to osteoporotic bone and increased bone formation once attached. One promising approach to direct the nanoparticles to osteoporotic bone is to attach antibodies to pentosidine on the nanoparticles since pentosidine is present in higher amounts in osteoporotic compared to healthy bone. A promising approach to increase bone growth once nanoparticles attach to osteoporotic bone, is to embed nanoparticles with regions of the bone growth factor: bone morphogenic protein-2 (or BMP-2). Results of this study demonstrated the successful synthesis of both crystalline HA and amorphous calcium phosphate nanoparticles. Furthermore, results showed that these nanoparticles can be functionalized with versatile amino groups. In this manner, this study takes the first steps toward utilizing calcium phosphate based nanoparticles to reverse bone loss associated with osteoporosis.

Stimulation of bone growth factor synthesis in human osteoblasts and fibroblasts after extracorporeal shock wave application

2010 ◽  
Vol 131 (3) ◽  
pp. 303-309 ◽  
Author(s):  
Joerg Hausdorf ◽  
Birte Sievers ◽  
Marcus Schmitt-Sody ◽  
Volkmar Jansson ◽  
Markus Maier ◽  
...  
Keyword(s):  
Shock Wave ◽  
Growth Factor ◽  
Bone Growth ◽  
Human Osteoblasts ◽  
Extracorporeal Shock Wave ◽  
Bone Growth Factor ◽  
Stimulation Of

Augmentation of Tendon Healing in an Intraarticular Bone Tunnel with Use of a Bone Growth Factor

2001 ◽  
Vol 29 (6) ◽  
pp. 689-698 ◽  
Author(s):  
Kyle Anderson ◽  
Aruna M. Seneviratne ◽  
Kazutaka Izawa ◽  
Brent L. Atkinson ◽  
Hollis G. Potter ◽  
...  
Keyword(s):  
Growth Factor ◽  
Bone Growth ◽  
Cruciate Ligament ◽  
Tendon Healing ◽  
Tendon Graft ◽  
Bone Tunnel ◽  
Resonance Imaging ◽  
Load To Failure ◽  
Anterior Cruciate ◽  
Bone Growth Factor

We hypothesized that an exogenous bone growth factor could augment healing of a tendon graft in a bone tunnel in a rabbit anterior cruciate ligament-reconstruction model. Seventy rabbits underwent bilateral anterior cruciate ligament reconstructions with a semitendinosus tendon graft. One limb received a collagen sponge carrier vehicle containing a mixture of bone-derived proteins while the contralateral limb was treated with either no sponge or a sponge without bone-derived proteins. The reconstruction was evaluated at 2, 4, or 8 weeks with histologic, biomechanical, and magnetic resonance imaging analysis. Histologic analysis demonstrated that specimens treated with bone-derived proteins had a more consistent, dense interface tissue and closer apposition of new bone to the graft, with occasional formation of a fibrocartilaginous interface, when compared with control specimens. The treated specimens had significantly higher load-to-failure rates than did control specimens. Treatment with bone-derived proteins resulted in an average increase in tensile strength of 65%. The treated specimens were stronger than control specimens at each time point, but the difference was greatest at 8 weeks. On the basis of signal characteristics and new bone formation, magnetic resonance imaging was useful for predicting which limb was treated, the site of failure, and the limbs with higher load-to-failure values. This study demonstrates the potential for augmenting tendon healing in an intraarticular bone tunnel using an osteoinductive growth factor.

SYNTHETIC BIOMATERIALS FOR RECONSTRUCTIVE SURGERY WITH THE ADDITION OF BMP-2 AND ERYTHROPOIETIN

2020 ◽  
pp. 50-52
Author(s):  
F. Senatov ◽  
A. Chubrik ◽  
A. Zimina ◽  
N. Strukova ◽  
M. Krivozubov ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Growth Factor ◽  
High Molecular Weight ◽  
Reconstructive Surgery ◽  
Bone Growth ◽  
Synthetic Materials ◽  
Bone Growth Factor ◽  
Ultra High Molecular Weight

Synthetic materials based on Ultra-High Molecular Weight PolyEthylene (UHMWPE), PolyEtherEtherKetone (PEEK) and PolyLActide (PLA) with the addition of recombinant bone growth factor BMP-2 and erythropoietin have been developed, which have high biocompatibility and osteoinductive properties.

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