Molecular mechanisms of nitric oxide-dependent inhibition of TPA-induced matrix metalloproteinase-9 (MMP-9) in MCF-7 cells

2009 ◽  
Vol 219 (2) ◽  
pp. 276-287 ◽  
Author(s):  
Christine Jespersen ◽  
Anke Doller ◽  
El-Sayed Akool ◽  
Malte Bachmann ◽  
Roswitha Müller ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Matrix Metalloproteinase ◽  
Molecular Mechanisms ◽  
Matrix Metalloproteinase 9 ◽  
Dependent Inhibition ◽  
Metalloproteinase 9 ◽  
Mcf 7

Nitric Oxide Inhibition Increases Aortic Wall Matrix Metalloproteinase-9 Expression

2002 ◽  
Vol 104 (1) ◽  
pp. 15-21 ◽  
Author(s):  
Matthew J. Eagleton ◽  
David A. Peterson ◽  
Vita V. Sullivan ◽  
Karen J. Roelofs ◽  
John A. Ford ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Matrix Metalloproteinase ◽  
Aortic Wall ◽  
Matrix Metalloproteinase 9 ◽  
Nitric Oxide Inhibition ◽  
Metalloproteinase 9 ◽  
Oxide Inhibition

scholarly journals Terminalia catappaExerts Antimetastatic Effects on Hepatocellular Carcinoma through Transcriptional Inhibition of Matrix Metalloproteinase-9 by Modulating NF-κB and AP-1 Activity

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Chao-Bin Yeh ◽  
Ming-Ju Hsieh ◽  
Yih-Shou Hsieh ◽  
Ming-Hsien Chien ◽  
Pen-Yuan Lin ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Matrix Metalloproteinase ◽  
Molecular Mechanisms ◽  
Nuclear Translocation ◽  
Matrix Metalloproteinase 9 ◽  
Tissue Inhibitor Of Metalloproteinase ◽  
Mrna Levels ◽  
Inhibitory Effects ◽  
Huh7 Cells ◽  
Metalloproteinase 9

High mortality and morbidity rates for hepatocellular carcinoma (HCC) in Taiwan primarily result from uncontrolled tumor metastasis. Previous studies have identified thatTerminalia catappaleaf extracts (TCE) exert hepatoprotective, antioxidative, antiinflammatory, anticancer, and antimetastatic activities. However, the effects of TCE on HCC and the underlying molecular mechanisms of its activities have yet to be fully elucidated. The present study's findings demonstrate that TCE concentration dependently inhibits human HCC migration/invasion. Zymographic and western blot analyses revealed that TCE inhibited the activities and expression of matrix metalloproteinase-9 (MMP-9). Assessment of mRNA levels, using reverse transcriptase polymerase chain reaction (PCR) and real-time PCR, and promoter assays confirmed the inhibitory effects of TCE on MMP-9 expression in HCC cells. The inhibitory effects of TCE on MMP-9 proceeded by upregulating tissue inhibitor of metalloproteinase-1 (TIMP-1), as well as suppressing nuclear translocation and DNA binding activity of nuclear factor-kappa B (NF-κB) and activating protein-1 (AP-1) on the MMP-9 promoter in Huh7 cells. In conclusion, TCE inhibits MMP-9 expression and HCC cell metastasis and, thus, has potential use as a chemopreventive agent. Its inhibitory effects are associated with downregulation of the binding activities of the transcription factors NF-κB and AP-1.

scholarly journals Matrix metalloproteinase-9 increases and Interleukin-10 reduces with increase in body mass index in polycystic ovary syndrome: A cross-sectional study

2020 ◽  
Author(s):  
Angel Mercy Sylus ◽  
Hanumanthappa Nandeesha ◽  
Thiagaraju Chitra
Keyword(s):  
Nitric Oxide ◽  
Body Mass Index ◽  
Polycystic Ovary Syndrome ◽  
Matrix Metalloproteinase ◽  
Body Mass ◽  
Polycystic Ovary ◽  
Interleukin 10 ◽  
Matrix Metalloproteinase 9 ◽  
Ovary Syndrome ◽  
Metalloproteinase 9

Background: Obesity, inflammation and alterations in matrix metalloproteinase-9 (MMP-9) and nitric oxide (NO) levels are involved in the development of polycystic ovary syndrome (PCOS). Objective: To investigate the relationship of MMP-9, NO and interleukin-10 (IL-10) with the increase in body mass index (BMI) in women with PCOS. Materials and Methods: Sixty two infertile PCOS women were included in the study. Serum levels of NO, IL-10 and MMP-9 were assessed in the women with increase in BMI. Results: MMP-9 was significantly increased (p = 0.029) and IL-10 (p = 0.015) was significantly reduced in obese PCOS subjects compared to those with lesser BMI. MMP- 9 levels positively correlated with the duration of infertility (r = 0.253, p = 0.047) and negatively correlated with NO levels (r = - 0.259, p = 0.042). A significant negative correlation between the interleukin-10 levels and the BMI (r = - 0.272, p = 0.033) was also found in the PCOS subjects. Conclusion: MMP-9 levels are increased in obese PCOS women and it is associated with NO levels and the duration of infertility. Key words: Body mass index, Interleukin-10, Nitric oxide, Matrix metalloproteinase-9.

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