scholarly journals The therapeutic applications of multipotential mesenchymal/stromal stem cells in skeletal tissue repair

2009 ◽  
Vol 218 (2) ◽  
pp. 237-245 ◽  
Author(s):  
Agnieszka Arthur ◽  
Andrew Zannettino ◽  
Stan Gronthos
Keyword(s):  
Stem Cells ◽  
Tissue Repair ◽  
Skeletal Tissue ◽  
Therapeutic Applications ◽  
Stromal Stem Cells

Multipotential Mesenchymal Stromal/Stem Cells in Skeletal Tissue Repair

2013 ◽  
pp. 82-102 ◽  
Author(s):  
Agnieszka Arthur ◽  
Andrew Zannettino ◽  
Stan Gronthos
Keyword(s):  
Stem Cells ◽  
Tissue Repair ◽  
Skeletal Tissue ◽  
Stromal Stem Cells

Stem Cells and Their Use in Skeletal Tissue Repair

2010 ◽  
pp. 103-124
Author(s):  
Laura Baumgartner ◽  
Vuk Savkovic ◽  
Susanne Trettner ◽  
Colette Martin ◽  
Nicole I. zur Nieden
Keyword(s):  
Stem Cells ◽  
Tissue Repair ◽  
Skeletal Tissue

Chapter 7. Mesenchymal Stromal/Stem Cells from Tissue Repair to Destruction of Tumor Cells

2010 ◽  
pp. 141-158
Author(s):  
Rita Bussolari ◽  
Giulia Grisendi ◽  
Luigi Cafarelli ◽  
Pietro Loschi ◽  
Laura Scarabelli ◽  
...  
Keyword(s):  
Stem Cells ◽  
Tumor Cells ◽  
Tissue Repair ◽  
Stromal Stem Cells

Adult Stem Cells and Biocompatible Scaffolds as Smart Drug Delivery Tools for Cardiac Tissue Repair

2013 ◽  
Vol 20 (28) ◽  
pp. 3429-3447 ◽  
Author(s):  
Stefania Pagliari ◽  
Sara Romanazzo ◽  
Diogo Mosqueira ◽  
Perpetua Pinto-do-O ◽  
Takao Aoyagi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Stem Cells ◽  
Tissue Repair ◽  
Adult Stem Cells ◽  
Cardiac Tissue ◽  
Smart Drug ◽  
Smart Drug Delivery

Recent approaches for isolating and culturing mouse bone marrow-derived mesenchymal stromal stem cells

2020 ◽  
Vol 15 ◽  
Author(s):  
Basem M. Abdallah ◽  
Hany M. Khattab
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Molecular Mechanisms ◽  
Replicative Senescence ◽  
Cellular Heterogeneity ◽  
High Yield ◽  
Mouse Strains ◽  
Mouse Bone Marrow ◽  
Differentiation Potential ◽  
Stromal Stem Cells

: The isolation and culture of murine bone marrow-derived mesenchymal stromal stem cells (mBMSCs) have attracted great interest in terms of the pre-clinical applications of stem cells in tissue engineering and regenerative medicine. In addition, culturing mBMSCs is important for studying the molecular mechanisms of bone remodelling using relevant transgenic mice. Several factors have created challenges in the isolation and high-yield expansion of homogenous mBMSCs; these factors include low frequencies of bone marrow-derived mesenchymal stromal stem cells (BMSCs) in bone marrow, variation among inbred mouse strains, contamination with haematopoietic progenitor cells (HPCs), the replicative senescence phenotype and cellular heterogeneity. In this review, we provide an overview of nearly all protocols used for isolating and culturing mBMSCs with the aim of clarifying the most important guidelines for culturing highly purified mBMSC populations retaining in vitro and in vivo differentiation potential.

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