Hepatic stellate cells modulate the differentiation of bone marrow mesenchymal stem cells into hepatocyte-like cells

2008 ◽  
Vol 217 (1) ◽  
pp. 138-144 ◽  
Author(s):  
Xing Deng ◽  
Yue-Xiang Chen ◽  
Xin Zhang ◽  
Jun-Ping Zhang ◽  
Chuan Yin ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Hepatic Stellate Cells ◽  
Stellate Cells ◽  
Marrow Mesenchymal Stem Cells

Human bone marrow mesenchymal stem cells suppress the proliferation of hepatic stellate cells by inhibiting the ubiquitination of p27

2017 ◽  
Vol 95 (6) ◽  
pp. 628-633 ◽  
Author(s):  
Liang Wang ◽  
Guang Bai ◽  
Fei Chen
Keyword(s):  
Cell Cycle ◽  
Stem Cells ◽  
Bone Marrow ◽  
Cell Proliferation ◽  
Mesenchymal Stem Cells ◽  
Cell Cycle Arrest ◽  
Hepatic Stellate Cells ◽  
Stellate Cells ◽  
Cycle Arrest ◽  
Marrow Mesenchymal Stem Cells

Bone marrow mesenchymal stem cells (BMSCs) have considerable therapeutic potential for the treatment of end-stage liver disease. Previous studies have demonstrated that BMSCs secrete growth factors and cytokines that inactivate hepatic stellate cells (HSCs), which inhibited the progression of hepatic fibrosis. The aim of this study was to determine the mechanism by which BMSCs suppress the function of HSCs in fibrosis. Our results showed that co-culture of BMSCs and HSCs induced cell cycle arrest at the G10/G1 phase and cell apoptosis of HSCs, which finally inhibited the cell proliferation of HSCs. Consistent with the cell cycle arrest, co-culture of BMSCs and HSCs increased the abundance of the cell cycle protein p27. Mechanistically, we further uncovered that following the co-culture with BMSCs, the expression level of the E3 ligase S-phase kinase-associated protein 2 (SKP2) that is responsible for the ubiquitination of p27 was decreased, which attenuated the ubiquitination of p27 and increased the stability of p27 in HSCs. Collectively, our results indicated the potential involvement of the SKP2–p27 axis for the inhibitory effect of BSMCs on the cell proliferation of HSCs.

scholarly journals Bone marrow mesenchymal stem cells stimulated by TNF-α enhance the apoptosis of hepatic stellate cells

2012 ◽  
Vol 20 (19) ◽  
pp. 1713
Author(s):  
Xian-Ke Luo ◽  
Zheng-Feng Lu ◽  
Hai-Xing Jiang ◽  
Shan-Yu Qin ◽  
Guo-Zhong Chen
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Hepatic Stellate Cells ◽  
Stellate Cells ◽  
Tnf Α ◽  
Marrow Mesenchymal Stem Cells

285 HYPOXIA – INDUCED MIGRATION OF HEPATIC STELLATE CELLS AND BONE MARROW – DERIVED MESENCHYMAL STEM CELLS INVOLVES COMMON REDOX MECHANISMS

2009 ◽  
Vol 50 ◽  
pp. S112 ◽  
Author(s):  
E. Novo ◽  
L. Valfrèdi Bonzo ◽  
C. Busletta ◽  
D. Povero ◽  
C. Paternostro ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Hepatic Stellate Cells ◽  
Stellate Cells

scholarly journals Common signalling events regulate migration and chemotaxis of hepatic stellate cells and bone marrow-derived mesenchymal stem cells

2008 ◽  
Vol 40 (10) ◽  
pp. A123
Author(s):  
L. Valfrè di Bonzo ◽  
E. Novo ◽  
S. Cannito ◽  
C. Busletta ◽  
C. Paternostro ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Hepatic Stellate Cells ◽  
Stellate Cells
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