scholarly journals Axial specification in mice: Ten years of advances and controversies

2007 ◽  
Vol 213 (3) ◽  
pp. 654-660 ◽  
Author(s):  
Jaime A. Rivera-Perez
Keyword(s):  
Axial Specification

scholarly journals Loss of Abdominal Muscle in Pitx2 Mutants Associated with Altered Axial Specification of Lateral Plate Mesoderm

PLoS ONE ◽  
2012 ◽  
Vol 7 (7) ◽  
pp. e42228 ◽  
Author(s):  
Diana Eng ◽  
Hsiao-Yen Ma ◽  
Jun Xu ◽  
Hung-Ping Shih ◽  
Michael K. Gross ◽  
...  
Keyword(s):  
Abdominal Muscle ◽  
Lateral Plate Mesoderm ◽  
Lateral Plate ◽  
Axial Specification

Axial specification for sensory organs versus non-sensory structures of the chicken inner ear

Development ◽  
1998 ◽  
Vol 125 (1) ◽  
pp. 11-20 ◽  
Author(s):  
D.K. Wu ◽  
F.D. Nunes ◽  
D. Choo
Keyword(s):  
Gene Expression ◽  
Inner Ear ◽  
Expression Patterns ◽  
Growth Factor Receptor ◽  
Gross Anatomy ◽  
Sensory Organ ◽  
Sensory Organs ◽  
Organ Formation ◽  
Sensory Structures ◽  
Axial Specification

A mature inner ear is a complex labyrinth containing multiple sensory organs and nonsensory structures in a fixed configuration. Any perturbation in the structure of the labyrinth will undoubtedly lead to functional deficits. Therefore, it is important to understand molecularly how and when the position of each inner ear component is determined during development. To address this issue, each axis of the otocyst (embryonic day 2.5, E2.5, stage 16–17) was changed systematically at an age when axial information of the inner ear is predicted to be fixed based on gene expression patterns. Transplanted inner ears were analyzed at E4.5 for gene expression of BMP4 (bone morphogenetic protein), SOHo-1 (sensory organ homeobox-1), Otx1 (cognate of Drosophila orthodenticle gene), p75NGFR (nerve growth factor receptor) and Msx1 (muscle segment homeobox), or at E9 for their gross anatomy and sensory organ formation. Our results showed that axial specification in the chick inner ear occurs later than expected and patterning of sensory organs in the inner ear was first specified along the anterior/posterior (A/P) axis, followed by the dorsal/ventral (D/V) axis. Whereas the A/P axis of the sensory organs was fixed at the time of transplantation, the A/P axis for most non-sensory structures was not and was able to be re-specified according to the new axial information from the host. The D/V axis for the inner ear was not fixed at the time of transplantation. The asynchronous specification of the A/P and D/V axes of the chick inner ear suggests that sensory organ formation is a multi-step phenomenon, rather than a single inductive event.

scholarly journals HoxGenes and Axial Specification in Vertebrates

2001 ◽  
Vol 41 (3) ◽  
pp. 687-697 ◽  
Author(s):  
Ann Campbell Burke ◽  
Julie L. Nowicki
Keyword(s):  
Axial Specification

scholarly journals Chordin is required for neural but not axial specification in sea urchin embryos

2006 ◽  
Vol 295 (1) ◽  
pp. 331
Author(s):  
Cynthia A. Bradham ◽  
Albert J. Poustka ◽  
David R. McClay
Keyword(s):  
Sea Urchin ◽  
Sea Urchin Embryos ◽  
Axial Specification

Axial specification in higher vertebrates

1991 ◽  
Vol 1 (2) ◽  
pp. 204-210 ◽  
Author(s):  
Peter Gruss ◽  
Michael Kessel
Keyword(s):  
Axial Specification

Some current problems in amphibian limb regeneration

1991 ◽  
Vol 331 (1261) ◽  
pp. 287-290 ◽  
Keyword(s):  
Retinoic Acid ◽  
Limb Regeneration ◽  
Positional Identity ◽  
Axial Specification

Limb regeneration in adult urodele amphibians proceeds by formation of a blastema at the amputation plane. This paper discusses how the blastema forms, and how its positional identity on the proximodistal axis is manifest. Retinoic acid is able to reset axial specification and there is particular interest in determining how it acts. Although limb regeneration is restricted among vertebrates to the urodeles, its mechanism poses fundamental questions in development biology.

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