Fibroblast growth factor receptor-induced phosphorylation of STAT1 at the golgi apparatus without translocation to the nucleus

2007 ◽  
Vol 212 (1) ◽  
pp. 148-156 ◽  
Author(s):  
Lucía Citores ◽  
Ling Bai ◽  
Vigdis Sørensen ◽  
Sjur Olsnes
Keyword(s):  
Growth Factor ◽  
Golgi Apparatus ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor Receptor ◽  
Growth Factor Receptor ◽  
Fibroblast Growth

Retention in the Golgi apparatus and expression on the cell surface of Cfr/Esl-1/Glg-1/MG-160 are regulated by two distinct mechanisms

2011 ◽  
Vol 440 (1) ◽  
pp. 33-41 ◽  
Author(s):  
Yuichiro Miyaoka ◽  
Hidenori Kato ◽  
Kazuki Ebato ◽  
Shigeru Saito ◽  
Naoko Miyata ◽  
...  
Keyword(s):  
Growth Factor ◽  
Golgi Apparatus ◽  
Cell Surface ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor Receptor ◽  
Growth Factor Receptor ◽  
Fibroblast Growth ◽  
Fgf Receptor ◽  
Juxtamembrane Region ◽  
Fgf Signalling

Cfr (cysteine-rich fibroblast growth factor receptor) is an Fgf (fibroblast growth factor)-binding protein without a tyrosine kinase. We have shown previously that Cfr is involved in Fgf18 signalling via Fgf receptor 3c. However, as Cfr is also known as Glg (Golgi apparatus protein)-1 or MG-160 and occurs in the Golgi apparatus, it remains unknown how the distribution of Cfr is regulated. In the present study, we performed a mutagenic analysis of Cfr to show that two distinct regions contribute to its distribution and stability. First, the C-terminal region retains Cfr in the Golgi apparatus. Secondly, the Cfr repeats in the extracellular juxtamembrane region destabilizes Cfr passed through the Golgi apparatus. This destabilization does not depend on the cleavage and secretion of the extracellular domain of Cfr. Furthermore, we found that Cfr with a GPI (glycosylphosphatidylinositol) anchor was predominantly expressed on the cell surface in Ba/F3 cells and affected Fgf18 signalling in a similar manner to the full-length Cfr, indicating that the interaction of Cfr with Fgfs on the cell surface is important for its function in Fgf signalling. These results suggest that the expression of Cfr in the Golgi apparatus and on the plasma membrane is finely tuned through two distinct mechanisms for exhibiting different functions.

Fibroblast Growth Factor Receptor Inhibitors

2012 ◽  
Vol 19 (4) ◽  
pp. 687-701
Author(s):  
Suneel Kumar B.V.S ◽  
Lakshmi Narasu ◽  
Rambabu Gundla ◽  
Raveendra Dayam ◽  
Sarma J.A.R.P
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor Receptor ◽  
Growth Factor Receptor ◽  
Fibroblast Growth
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